시라자 추출물을 함유하는 면역질환의 치료 및 예방을 위한 면역증강용 조성물

• Published in: 동의생리병리학회지 Vol. 21; no. 3; pp. 700 - 704
• Main Authors: 박길순(Gil Soon Park), 장인애(In Ae Chang), 김윤철(Youn Chul Kim), 이무형(Moo Hyung Lee), 신혜영(Hye-Young Shin), 최두영(Du Young Choi), 윤용갑(Yong Gab Yun), 박현(Hyun Park)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 2007
• Subjects: 한의학; Anethi Fructus; co-stimulatory molecule; TNF-a; Nitric oxide
• ISSN: 1738-7698; 2288-2529; 2283-2529

In the recent, increased concern has been focused on the pharmacology and clinical utility of herbal extracts and derivatives as a drug or adjunct to chemotherapy and immunotherapy. Here we investigated the role of the extract of Anethi Fructus in the expression of inflammatory mediators, surface molecule, and related receptors in vitro. In murine macrophage RAW 264.7 cells and peritoneal macrophages of C57BL/6N mice, water extract of Anethi Fructus increased the production of secretary tumor necrosis factor (TNF)-a and Nitric oxide (NO), and the expression level of CD14, LPS co-receptor and CD86, co-stimulatory molecule compared to negative natural extract ex vivo. The water extract of Anethi Fructus increased the production of interferon (IFN)-g from splenocytes. Also, water extract of Anethi Fructus increased ConA-induced cell proliferation. These results suggest that water extract of Anethi Fructus may enhance the immune response through immune modulation of macrophage and lymphocytes.