삼채(Allium Hookeri)의 급여가 당뇨마우스의 당질 대사에 미치는 영향

• Published in: 생약학회지 Vol. 46; no. 1; pp. 78 - 83
• Main Authors: 김남석(Nam Seok Kim), 최봉겸(Bong Kyoum Choi), 이선혜(Seon Hye Lee), 장환희(Hwan Hee Jang), 김정봉(Jung Bong Kim), 김행란(Haeng Ran Kim), 김대근(Dae Keun Kim), 김유석(You Suk Kim), 양재헌(Jae Heon Yang), 김현주(Hyun Ju Kim), 이성현(Sung Hyen Lee)
• Format: Journal Article
• Language: Korean
• Published: 한국생약학회 2015
• Subjects: 약학; Allium Hookeri; Glucose; Diabetic mice; HbA1c; Insulin
• ISSN: 0253-3073; 2288-9299

This study was conducted to verify the potential of Allium hookeri to control glucose metabolism in a diabetes model. We fed the experimental diets (AL, AR, Dex) supplemented with the powder of leaf, root, or dextrin as a positive control, respectively at 3% of diet to the diabetic mice (C57BLKS/J, db/db) for 8 weeks. Control mice were fed with the diet supplemented with cornstarch (Cont) at 3% level of diet. At 8th week of feeding the diets, we measured body weight, blood glucose, HbA1c, and plasma insulin levels and conducted an oral glucose tolerance test (OGTT) and staining insulin immunoreactive cells in islets of pancreas. AL group treated with the leaf of A. hookeri showed significantly lower blood glucose and HbA1c levels, higher plasma insulin levels, and increased density of insulin immunoreactive cells compared with the Cont group. During the OGTT, AL group showed lower blood glucose levels than the Cont group for 120 min. Based on these results, leaf of A. hookeri is considered to be effective in improving glucose tolerance by partially affecting insulin secretion and it may be used to prevent and treat diabetic disease.