배 추출 Phenolic compound 투여가 흰쥐의 혈압 변화, 혈장 Renin, ANP 및 Cardiac hypertrophy에 미치는 영향

• Published in: 동의생리병리학회지 Vol. 17; no. 2; pp. 363 - 367
• Main Authors: 나창수(Chang Su Na), 윤대환(Dae Hwan Yun), 최동희(Dong Hee Choi), 김정상(Jeong sang Kim), 조춘화(Chun Hwa Jo), 은종방(Jong Bang Eun)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 2003
• Subjects: 한의학; Blood pressure; ANP; Plasma renin; 2K1C; Pear phenolic compound; Cardiac hypertophy
• ISSN: 1738-7698; 2288-2529; 2283-2529

Oriental pear was used as treatment of asthma, control of blood pressure tonic medicine vasoaction, diabetes in oriental medicine. In this study, it was investigated that pear phenolic compound effects on cardiovascular system as blood pressure and renin and atrial natriuretic peptide(ANP) in plasma, Cardiac hypertrophy. The experiments were performed on Sprague Dawley rats, 2K1C hypertension model was prepared by constricting the left renal artery with a sliver clip. Animals were then divided into four groups, 5mg/Kg(PPC-A) 10mg/Kg(PPC-B) 15mg/Kg(PPC-c) and control group. Pear phenolic compound solution were supplied with them for 3weeks, a day's interval. The results are that The blood pressure was significantly decreased at 15days in PPC-A group than control group. The plasma ANP was increased in PPC-A and PPC-C group, and cardiac hypertrophy was significantly decrease in PPC-C group compared with control group.