난소절제 흰쥐에서 흑미 호분층 추출물의 체지방 감소 효과

• Published in: 東아시아食生活學會誌 Vol. 25; no. 3; pp. 425 - 431
• Main Authors: 이영민(Young Min Lee), 남송이(Song Yee Nam), 장환희(Hwan Hee Jang), 김정봉(Jung Bong Kim), 김행란(Haeng Ran Kim), 이해정(Hae-Jeung Lee), 이성준(Sung-Joon Lee), 박계원(Kye Won Park), 이성현(Sung Hyen Lee)
• Format: Journal Article
• Language: Korean
• Published: 동아시아식생활학회 2015
• Subjects: 생활과학; body fat mass; fecal lipid; leptin; black rice extract; Estrogen deficiency
• ISSN: 1225-6781; 2288-8802
• DOI: 10.17495/easdl.2015.6.25.3.425

Estrogen deficiency is associated with increased body weight and fat mass, resulting in obesity-associated complications such as insulin resistance, cardiovascular disease, and type-2 diabetes. The present study was performed to investigate the effect of black rice (Oryza sativa L.) extracts (BRE) on body weight and fat mass in ovariectomized rats. Ovariectomized (or sham-operated) rats were randomly blocked into three groups (n=8~10 per group): sham operated group (S), ovariectomized control group (OVX), and ovariectomized group with BRE 30 mg/kg B.W. (BRE). High fat diet (fat calories 45%) was fed to all experimental rats for 12 weeks. Final body weight, weight gain, and body fat weight showed significant increases in the OVX group, whereas they were reduced by BRE supplementation. Serum TAG, T-chol level, and adipocyte size were not significantly different among the three groups. However, ovariectomy-induced hepatic steatosis was improved in BRE-treated group. Moreover, in the BRE group, serum leptin levels was significantly lower and fecal total lipid concentrations was significantly higher compared to the OVX group. The gathered data suggest that BRE is a potentially useful ingredient to protect against estrogen deficiency-related obesity and its related diseases.