폴리감마글루탐산의 동결 건조 과정의 실험적 연구

• Published in: 설비공학 논문집, 27(12) Vol. 27; no. 12; pp. 645 - 651
• Main Authors: 강지수(Jisu Kang), 심연호(Yeon-Ho Sim), 변시예(Si-Ye Byun), 장영수(Young Soo Chang)
• Format: Journal Article
• Language: Korean
• Published: 대한설비공학회 2015
• Subjects: 기계공학; Vacuum freeze drying(진공 동결 건조); Glass transient temperature(유리전이온도); Poly γ  glutamic acid(폴리감마글루탐산); Biomaterial(바이오 소재)
• ISSN: 1229-6422; 2465-7611
• DOI: 10.6110/KJACR.2015.27.12.645

This paper presents an experimental study on the freeze drying process for poly ${\gamma}$ glutamic acid. The physical properties of poly ${\gamma}$ glutamic acid are measured during the freeze-drying process. The moisture contents of poly ${\gamma}$ glutamic acid according to the glass transient temperature are obtained by DSC (Differential Scanning Calorimetry) analysis. The end point of primary drying for the poly ${\gamma}$ glutamic acid with a thickness of 3 mm is obtained by measuring the thickness of the dried layer, the amount of moisture evaporation, the moisture content, and the pressure in the drying vacuum chamber during the freeze-drying process. By considering the variation in the glass transient temperature with respect to the moisture content of the material, a control schedule for the heating plate temperature is suggested during the secondary drying process.