CD4+ Jurkat T 세포주에서 Th1과 Th2 사이토가인 조절에 미치는 황금 유래 Baicalin, Baicalein 및 Wogonin의 효과

• Published in: 동의생리병리학회지 Vol. 19; no. 4; pp. 922 - 927
• Main Authors: 김용준(Young Jun Kim), 이정치(Jeong Chi Lee), 김홍용(Hong Yong Kim), 설광화(Guanghua Xie), 윤용갑(Yong Gab Yun), 장선일(Seon ll Jang)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 2005
• Subjects: 한의학; Scutellaria Radix; baicalin; Thl; Jurkat T cells; baicalein; wogonin; Th2
• ISSN: 1738-7698; 2288-2529; 2283-2529

In the present study, baicalin, baicalein, and wogonin, a major flavone isolated from Scutellaria Radix were examined for their effects on PMA-induced Interlukin-6 (IL-6), $interferon-\gamma(IFN-\gamma)$, tumor necrosis factor $(TNF)-\alpha$, IL-4, IL-10, and IL-13 productions in the PMA-stimulated $CD4^+$ Jurkat T cells. These three compounds inhibited PMA-induced Th1 cytokine $(IL-6,\;IFN-\gamma,\;TNF-\alpha)$ and Th2 cytokine (IL-4 and IL-13) productions in a concentration-dependent manner. But wogonin, but not baicalin baicalein, increased PMA-induced IL-10 production. These results suggest that baicalin, baicalein, and wogonin, a major flavone modulate Th1 and Th2 cytokine productions in $CD4^+$ Jurkat T cells and these properties may contribute to the anti-atopic dermatitis activity of Scutellaria Radix.