엉겅퀴 잎 수용성 추출물의 콜라겐 유도 관절염 억제효과

• Published in: 동의생리병리학회지 Vol. 27; no. 4; pp. 416 - 421
• Main Authors: 강현주(Hyun Ju Kang), 김현수(Hyeon Soo Kim), 전인화(In Hwa Jeon), 목지예(Ji Ye Mok), 정승일(Seung Il Jeong), 심재석(Jae Suk Shim), 장선일(Seon Il Jang)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 2013
• Subjects: 한의학; cytokine regulation; collagen-induced arthritis; leaf extract; Cirsium japonicum var. ussuriense; Cirsium japonicum var; ussuriense
• ISSN: 1738-7698; 2288-2529; 2283-2529
• DOI: 10.15188/kjopp.2013.08.27.4.416

Cirsium japonicum var. ussuriense is often used in treatment of human disease such as hemorrhage, blood congestion and inflammation. The present study has been undertaken to investigate the effect of the leaf extract from C. japonicum var. ussuriense (CLE) on the development of collagen-induced arthritis (CIA) in DBA1/J mice. CLE administration suppressed markedly the arthritis incidence and arthritis score in CIA mice. Also, CLE significantly suppressed the release of $PGE_2$, TNF-${\alpha}$, IL-4 and IL-6 in CIA mice. However, CLE significantly increased the production of IL-10, but not IL-4. These results suggest that CLE suppress inflammatory mediators and regulates Th1 and Th2 cytokines. These properties may contribute to the anti-arthritis action of CLE.