포도잎으로부터 분리된 Quercetin-3-O-glucuronide의 LPS로 유도된 BV2 미세아교세포에서의 항염증 효과

Grapes has long been used for food, and reported as containing polyphenol which has antioxidant and anti-cancer effects. Neuroinflammation is chronic inflammation at the brain, lead to neurodegenerative diseases. In this study, quercetin-3-O-glucuronide (QG) isolated from the leaf of Vitis labruscan...

Full description

Saved in:
Bibliographic Details
Published in생약학회지 Vol. 45; no. 1; pp. 17 - 22
Main Authors 윤치수(Chi Su Yoon), 김동철(Dong Cheol Kim), 고원민(Won Min Ko), 김경수(Kyoung Su Kim), 이동성(Dong Sung Lee), 김대성(Dae Sung Kim), 조형권(Hyoung Kwon Cho), 서정원(Jung Won Seo), 김성연(Sung Yeon Kim), 오현철(Hyun Cheol Oh), 김윤철(Youn Chul Kim)
Format Journal Article
LanguageKorean
Published 한국생약학회 2014
Subjects
Online AccessGet full text
ISSN0253-3073
2288-9299

Cover

More Information
Summary:Grapes has long been used for food, and reported as containing polyphenol which has antioxidant and anti-cancer effects. Neuroinflammation is chronic inflammation at the brain, lead to neurodegenerative diseases. In this study, quercetin-3-O-glucuronide (QG) isolated from the leaf of Vitis labruscana has anti-neuroinflammatory effects. QG were investigated using MTT assay, western blot, nitric oxide (NO) assay, prostaglandin $E_2$ ($PGE_2$) assay, cytokine assay in lipopolysaccharide (LPS)-induced inflammation in BV2 cells. QG dose-dependently attenuated the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), accordingly inhibited the production of NO and $PGE_2$. QG decreases the levels of proinflammatory cytokine such as tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), interlukin-$1{\beta}$ (IL-$1{\beta}$). Thereby, QG may offer therapeutic potential for treatment of neurodegenerative disease related to neuroinflammation.
Bibliography:KISTI1.1003/JNL.JAKO201413240715576
G704-000753.2014.45.1.004
ISSN:0253-3073
2288-9299