낙지다리 식물 추출물의 알레르기 억제효과

• Published in: Han'gug sigpum wi'saeng anjeonseong haghoeji Vol. 30; no. 4; pp. 376 - 382
• Main Authors: 조소영, 김영미, Jo, So young, Kim, Young Mi
• Format: Journal Article
• Language: Korean
• Published: 한국식품위생안전성학회 31.12.2015
• Subjects: 식품과학; mast cell; Penthorum chinense extract (PCE); allergy; syk kinases; anti-allergic effect
• ISSN: 1229-1153; 2465-9223

Allergic diseases have rapidly increased in recent years. Mast cells play a critical role in IgE-mediated allergy responses and, therefore, closely associated with rhinitis, asthma, and atopic dermatitis. We studied anti-allergic effect of Penthorum chinense extract (PCE) in vitro and in vivo. PCE inhibited the degranulation of mast cells by antigen stimulation and its effect was dose-dependent and reversible in mast cells. PCE also suppressed the production of inflammatory cytokines such as TNF-${\alpha}$ and IL-4 by antigen in mast cells. Mechanistically, PCE inhibited the activation of Syk/LAT pathway which is a key signaling pathway for the activation of mast cells by antigen. Notably, PCE suppressed IgE-mediated allergic responses by antigen in mice. These results strongly suggest that PCE is a potential candidate for anti-allergic treatment.