급성 중독으로 응급실에 내원하여 사망한 환자의 원인물질 및 시간 분포

• Published in: 대한임상독성학회지 Vol. 19; no. 2; pp. 65 - 71
• Main Authors: 이현재, Hyeonjae Lee, 좌민홍, Minhong Choa, 한은아, Eunah Han, 고동률, Dong Ryul Ko, 고재욱, Jaiwoog Ko, 공태영, Taeyoung Kong, 조준호, Junho Cho, 정성필, Sung Phil Chung
• Format: Journal Article
• Language: Korean
• Published: 대한임상독성학회 30.12.2021
• Subjects: Drug Overdose; Mortality; Poisoning; 응급의학; Drug Overdose; Mortality; Poisoning
• ISSN: 1738-1320; 2508-6332
• DOI: 10.22537/jksct.2021.19.2.65

Purpose: The purpose of this study was to investigate the cause of acute fatal poisoning and the time of death by analyzing the National Emergency Department Information System (NEDIS) of South Korea. Methods: The NEDIS data from 2014 to 2018 excluding non-medical visits were used for this study. The patients with acute poisoning were extracted using diagnostic codes. The toxic substances were classified into pharmaceuticals, pesticides, gases, artificial poisonous substances, and natural toxic substances. Patients were classified according to the time of death, place of death, and region. In each case, the most causative substances of poisoning were identified. Results: There were 380,531 patients including poisoning-related diagnoses, of which 4,148 (1.1%) died, and the WHO age-standardized mortality rate was 4.8 per 100,000. Analysis of 2,702 death patients whose primary diagnosis was acute poisoning, the most common cause of poisoning death was pesticides (62%), followed by therapeutic drugs, gas, and artificial toxic substances. Herbicides were the most common pesticides at 64.5%. The proportion of mortality by time, hyperacute (< 6 h) 27.9%, acute (6-24 h) 32.6%, subacute (1-7 d) 29.7%, and delayed period ( >7 d) were 9.8%. Conclusion: This study suggests that the most common cause of poisoning death was pesticides, and 60% of deaths occurred within 24 hours. The 71% of mortality from pesticides occurred within 6-24 hours, but mortality from gas was mostly within 6 hours. According to the geographic region, the primary cause of poisoning death was varied to pesticides or pharmaceuticals.