글루포시네이트 암모늄 제초제 중독환자에서 혈중 암모니아 농도와 사망률과의 연관성에 대한 연구

• Published in: 대한임상독성학회지 Vol. 18; no. 2; pp. 136 - 140
• Main Authors: 고은나래, Eun Na Lae Ko, 김동훈, Dong Hoon Kim, 이수훈, Soo Hoon Lee, 정진희, Jin Hee Jeong, 이상봉, Sang Bong Lee, 성애진, Aejin Sung, 서자현, Ja Hyoen Suh, 강창우, Changwoo Kang
• Format: Journal Article
• Language: Korean
• Published: 대한임상독성학회 30.12.2020
• Subjects: Glufosinate ammonium; Herbicide; Mortality; Poisoning; 응급의학; Glufosinate ammonium; Poisoning; Mortality; Herbicide
• ISSN: 1738-1320; 2508-6332
• DOI: 10.22537/jksct.2020.18.2.136

Purpose: The association of the initial serum ammonia level with in-hospital mortality in patients with acute glufosinate-ammonium herbicide poisoning was studied. Methods: This retrospective cohort study was conducted between March 2012 and August 2019 in the emergency department after glufosinate-ammonium herbicide poisoning. Survivors and non-survivors were analyzed using a Mann-Whitney U test and Fisher’s exact test. Multivariate logistic regression analysis was performed to determine the independent risk factors for mortality. Results: One hundred and six patients were enrolled; 11 died, yielding a mortality of 10.4%. The serum bicarbonate level was significantly lower in the non-survival group than the survival group. Age, serum ammonia, blood urea nitrogen, creatinine levels, SOFA score, and APACHE II score were significantly higher in the non-survival group than the survival group. Age, serum ammonia, and creatinine level were independent risk factors for mortality in multivariate logistic regression analysis. Conclusion: The initial serum ammonia level is associated with mortality in patients with acute glufosinate herbicide poisoning.