수청바이러스의 M, L 분절의 염기서열 및 계통 분석

• Published in: Journal of bacteriology and virology Vol. 37; no. 2; pp. 111 - 118
• Main Authors: 김은주, Eun Ju Kim, 문성실, Sung Sil Moon, 송기준, Ki Joon Song, 송진원, Jin Won Song, 박광숙, Kwang Sook Park, 백락주, Luck Ju Baek
• Format: Journal Article
• Language: Korean
• Published: 대한바이러스학회 2007; 대한미생물학회
• Subjects: Apodemus peninsulae; Hantavirus; Soochong virus; Apodemus peninsulae; Soochong virus; Hantavirus
• ISSN: 1598-2467; 2093-0429

Hantaan virus (HTNV) and Seoul virus (SEOV) have mainly been known as the cause of hemorrhagic fever with renal syndrome (HFRS) in Korea since HTNV has been isolated from Korean field mouse, Apodemus agrarius in 1976 and SEOV has been isolated from Rattus norvegicus in 1980. Soochong virus-1, -2, -3, -4 (SOOVs) were isolated from lung tissues of four Apodemus peninsulae captured on August 1997 at Mt. Gyebang in Hongcheon-gun, Mt. Gachil, Inje-gun, Gangwon Province, and in September 1998 at Mt. Deogyu, Muju-gun, Jeollabuk Province. Apodemus peninsulae is the second-most dominant field rodent species found throughout Korea. To determine phylogenetic analysis of SOOVs, we entirely identified nucleotide sequences of M and L segments. The length of M segment was 3,615 bp and L segment was 6,533 bp. SOOVs were diverged from HTNV by $22.7{\sim}23.3%$ and SEOV by $36.3{\sim}37.2%$, in M segment. In addition, L segment was diverged from HTNV by $21.8{\sim}22.0%$ and SEOV by $30.3{\sim}30.5%$. SOOVs sequence compared with Amur virus (AMRV) in M segment showed that SOOVs were different with AMRV about $14.6{\sim}16.2%$ in nucleotide sequences. Neighbor-joining phylogenetic analysis based on entire sequences of the M and L segment indicated that the SOOVs sequences present a separate lineage with HTNV, SEOV and AMRV. SOOVs constituted an individual cluster on the phylogenetic tree and they composed a phylogenic lineage separately. According to these data, SOOVs could be classified as a new hantavirus.