뇌혈관질환 환자에 대한 청심연자탕(淸心連子湯), 도담탕(導痰湯), 혈부축어탕(血府逐瘀湯), 보신익뇌탕(補腎益腦湯)의 간기능과 신기능 안전성 평가 : 후향적 연구

• Published in: 대한한방내과학회지 Vol. 44; no. 3; pp. 439 - 454
• Main Authors: 김민화, 조임학, 남이랑, 김마리아, 구기범, 이세연, 권정남, 이인, 홍진우, 윤영주, 김소연, 한창우, 박소정, 최준용, 신현규, Min-hwa Kim, Im-hak Cho, I-rang Nam, Maria Kim, Ki-beom Ku, Se-yeon Lee, Jung-nam Kwon, In Lee, Jin-woo Hong, Young-ju Yun, So-yeon Kim, Chang-woo Han, So-jung Park, Jun-yong Choi, Hyeun-kyoo Shin
• Format: Journal Article
• Language: Korean
• Published: 대한한방내과학회 01.06.2023
• Subjects: 한의학; dodam-tang; boshiniknoe-tang; cerebrovascular diseases; hepatic and renal function; hyulbuchuko-tang; cheongsimyeonja-tang
• ISSN: 1226-9174

Objectives: As Korea transitions into an aging society, the incidence of cerebrovascular disease is expected to increase. Herbal medicine is commonly used in Oriental medicine to treat cerebrovascular disease. However, there is insufficient clinical evidence to actively support the safety of herbal medicine in clinical practice. Therefore, the aim of this study was to determine the toxicity and safety of four herbal medicines (Cheongsimyeonja-tang, Dodam-tang, Hyeolbuchukso-tang, and Boshiniknai-tang) in patients with cerebrovascular disease. Methods: This study used electronic medical records to analyze patients admitted to an oriental medicine hospital from April 1, 2017, to December 31, 2020. Liver and renal function values at the time of admission and discharge were compared. Results: A total of 25 patients were included in this study. We found no significant differences in various variables, such as complete blood count, liver-renal function test, and urine, before and after the administration of the four herbal medicines. Additionally, no significant adverse events related to herbal medicine were observed. Conclusions: This study confirmed the safety of the four herbal medicines in patients with cerebrovascular disease who were hospitalized in a single Oriental medicine hospital.