형태 계측학적 분석과 $ThinPrep^{(R)}$ 액상 소변세포검사를 이용한 악성 요로상피 세포 검출

Urothelial carcinoma accounts for 90% of all the cases of bladder cancer. Although many cases can be easily managed by local excision, urothelial carcinoma rather frequently recurs, tends to progress to muscle invasion, and requires regular follow-ups. Urine cytology is a main approach for the follo...

Full description

Saved in:
Bibliographic Details
Published inTaehan Sepo Pyŏngri Hakhoe chi Vol. 19; no. 2; pp. 136 - 143
Main Authors 신봉경, 이영석, 정회선, 이상호, 김현철, 김애리, 김인선, 김한겸, Shin, Bong-Kyung, Lee, Young-Suk, Jeong, Hoi-Seon, Lee, Sang-Ho, Kim, Hyun-Chul, Kim, A-Ree, Kim, In-Sun, Kim, Han-Kyeom
Format Journal Article
LanguageKorean
Published 대한세포병리학회 01.09.2008
Subjects
Online AccessGet full text
ISSN1017-0391

Cover

More Information
Summary:Urothelial carcinoma accounts for 90% of all the cases of bladder cancer. Although many cases can be easily managed by local excision, urothelial carcinoma rather frequently recurs, tends to progress to muscle invasion, and requires regular follow-ups. Urine cytology is a main approach for the follow-up of bladder tumors. It is noninvasive, but it has low sensitivity of around 50% with using the conventional cytospin preparation. Liquid-based cytology (LBC) has been developed as a replacement for the conventional technique. We compared the cytomorphometric parameters of $ThinPrep^{(R)}$ and cytospin preparation urine cytology to see whether there are definite differences between the two methods and which technique allows malignant cells to be more effectively discriminated from benign cells. The nuclear-to-cytoplasmic ratio value, as measured by digital image analysis, was efficient for differentiating malignant and benign urothelial cells, and this was irrespective of the preparation method and the tumor grade. Neither the $ThinPrep^{(R)}$ nor the conventional preparation cytology was definitely superior for distinguishing malignant cells from benign cells by cytomorphometric analysis of the adequately preserved cells. However, the $ThinPrep^{(R)}$ preparation showed significant advantages when considering the better preservation and cellularity with a clear background.
Bibliography:KISTI1.1003/JNL.JAKO200835741868652
G704-001737.2008.19.2.021
ISSN:1017-0391