양극성장애에 대한 Valproic Acid와 Olanzapine 치료 중 발생한 호산구증가증과 전신증상을 동반한 약물발진(DRESS) 증후군 1예

• Published in: Journal of the Korean Society of Biological Psychiatry Vol. 24; no. 3; pp. 162 - 166
• Main Authors: 이웅, 임세원, Lee, Ung, Lim, Se-Won
• Format: Journal Article
• Language: Korean
• Published: 대한생물정신의학회 01.08.2017
• Subjects: 정신과학
• ISSN: 1225-8709; 2005-7571; 1225-8709
• DOI: 10.22857/kjbp.2017.24.3.009

Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a potentially life-threatening, medication-induced hypersensitivity reaction with long latency. It is characterized by fever, rash, leukocytosis with eosinophilia, atypical lymphocytosis, and internal organ involvement. The most common causes of DRESS syndrome are sulfonamides and anticonvulsants such as carbamazepine and lamotrigine. However, valproic acid and olanzapine could develop DRESS syndrome. We report a case of DRESS syndrome associated with valproic acid and olanzapine in a 41 years old male patient with bipolar disorder.