조현병 환자에서 성별에 따른 검지 대 약지의 길이 비율과 뇌파 동시성의 관련성

• Published in: Journal of the Korean Society of Biological Psychiatry Vol. 21; no. 4; pp. 151 - 160
• Main Authors: 최병하, 이유상, 한은선, 김성균, 정재승, 이승연, 김범준, Choi, Byungha, Lee, Yu Sang, Han, Eun-Seun, Kim, Seongkyun, Jeong, Jaeseung, Lee, Seungyeoun, Kim, Bum Joon
• Format: Journal Article
• Language: Korean
• Published: 대한생물정신의학회 01.11.2014
• Subjects: 정신과학; -
• ISSN: 1225-8709; 2005-7571

Objectives Prenatal testosterone is known to influence both cerebral laterality and 2nd to 4th digit ratio (2D : 4D). Epigenetic changes are thought to play some role in it. We studied sex-related differences between 2D : 4D and cerebral laterality in patients with schizophrenia and controls to examine the effects of prenatal testosterone in the development of schizophrenia. Methods Forty one men (18 schizophrenic patients and 23 controls) and 40 women (17 schizophrenic patients and 23 controls) were recruited from one psychiatric hospital in Korea. The 2D : 4D and electroencephalographic (EEG) coherence in 19 channels (66 pairs of interhemispheric coherence and 54 pairs of intrahemispheric coherence) were measured. The sex-related statistical analyses between 2D : 4D and EEG coherence in controls and patients with schizophrenia were performed using multiple regression. Results In male patients, the relationship between 2D : 4D and right intrahemispheric EEG coherence showed mainly positive correlation in delta and theta frequency bands, while it showed negative correlation in male controls. In female patients, the relationship between 2D : 4D and interhemispheric EEG coherence showed stronger positive correlation in alpha and beta frequency bands, while it showed weaker positive correlation in female controls. Conclusions Low prenatal testosterone may play certain roles in altered correlation between 2D : 4D and cerebral laterality in schizophrenia and the development of schizophrenia by epigenetic mechanism.