한국인의 흡연과 사망 위험에 관한 코호트 연구

• Published in: Journal of preventive medicine and public health Vol. 43; no. 2; pp. 151 - 158
• Main Authors: 이은하, 박수경, 고광필, 조인성, 장성훈, 신해림, 강대희, 유근영, Lee, Eun-Ha, Park, Sue-K, Ko, Kwang-Pil, Cho, In-Seong, Chang, Soung-Hoon, Shin, Hai-Rim, Kang, Dae-Hee, Yoo, Keun-Young
• Format: Journal Article
• Language: Korean
• Published: 대한예방의학회 01.03.2010
• Subjects: 예방의학; Cigarette smoking; Mortality; Cohort studies
• ISSN: 1975-8375; 2233-4521

Objectives: The aim of this study was to evaluate the association between cigarette smoking and total mortality, cancer mortality and other disease mortalities in Korean adults. Methods: A total of 14 161 subjects of the Korean Multi-center Cancer Cohort who were over 40 years of age and who were cancer-free at baseline enrollment reported their lifestyle factors, including the smoking status. The median follow-up time was 6.6 years. During the follow-up period from 1993 to 2005, we identified 1159 cases of mortality, including 260 cancer mortality cases with a total of 91 987 person-years, by the national death certificate. Cox proportional hazard regression model was used to estimate the hazard ratio (HR) of cigarette smoking for total mortality, cancer mortality and disease-specific mortality, as adjusted for age, gender, the geographic area and year of enrollment, the alcohol consumption status, the education level and the body mass index (BMI). Results: Cigarette smoking was significantly associated with an increased risk of total mortality, all-cancer mortality and lung cancer mortality (p-trend, < 0.01, <0.01, <0.01, respectively). Compared to non-smoking, current smokers were at a higher risk for mortality [HR (95% CI)=1.3 (1.1 - 1.5) for total mortality; HR (95% CI)=1.6 (1.1 -2.2) for all-cancer mortality; HR (95% CI)=3.9 (1.9-7.7) for lung cancer mortality]. Conclusions: This study's results suggest that cigarette smoking might be associated with total mortality, all-cancer mortality and especially lung cancer mortality among Korean adults.