배암차즈기(Salvia plebeia R.) 에탄올 추출물의 항산화 및 항알레르기 효과

• Published in: 생약학회지 Vol. 45; no. 4; pp. 332 - 337
• Main Authors: 최봉겸(Bong Kyoum Choi), 이선혜(Seon Hye Lee), 김남석(Nam Seok Kim), 조수연(Soo Yeon Cho), 장환희(Hwan Hee Jang), 김정봉(Jung Bong Kim), 이영민(Young Min Lee), 윤순근(Sungeun Yoon), 이성현(Sung Hyen Lee)
• Format: Journal Article
• Language: Korean
• Published: 한국생약학회 2014
• Subjects: Salvia plebeia R; Anti-allergic; Anti-oxidative; Asthma; RBL-2H3
• ISSN: 0253-3073; 2288-9299

The Salvia plebeia R. which is the biennial plant belonging to the labiatae department, grows widely in Korea. This study was performed to evaluate the antioxidant activities and anti-allergic effects of Salvia plebeia R. leaves (SPLE) or roots (SPRE). Using ethanol extracts, both leaves and roots induced significant radical scavenging activity against DPPH and ABTS radicals in a dose dependent manner (p<0.05). Superoxide dismutase (SOD)-like activity of SPLE was significantly higher than that of SPRE at all concentrations. Treatment of the RBL-2H3 cells with SPLE and SPRE in vitro decreased ${\beta}$-Hexosaminidase release and significantly inhibited IgE-antigen complex-mediated IL-4 and TNF-${\alpha}$ mRNA expression in RBL-2H3 cells. These findings suggest that Salvia plebeia R. can protect or reduce allergic asthma through high antioxidant and anti-allergic reactions.