산지별 상황버섯의 사이토칸인 조절 효과에 관한 연구

Pellinus linteus has been used for the prevention of cancer traditionally. There are three origins of Pellinus linteus, Korea, China and Cambodia. However, their immunological activities were not evlauated comparatively. Thus, this study was done to evaluate immunomodulatory effects of Phellinus lin...

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Published in동의생리병리학회지 Vol. 17; no. 4; pp. 898 - 904
Main Authors 김진수(Jin Soo Kim), 김정효(Jung Hyo Kim), 이효정(Hyo Jeong Lee), 길재호(Jae Ho Khil), 김성훈(Sung Hoon Kim), 김동희(Dong Hee Kim)
Format Journal Article
LanguageKorean
Published 한의병리학회 2003
Subjects
cytokine
Cambodia-Pl
China-Pl
IL-12
Pellinus linteus
Korea-Pl
three origins
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ISSN1738-7698
2288-2529
2283-2529

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Summary:Pellinus linteus has been used for the prevention of cancer traditionally. There are three origins of Pellinus linteus, Korea, China and Cambodia. However, their immunological activities were not evlauated comparatively. Thus, this study was done to evaluate immunomodulatory effects of Phellinus linteus(PL) from Korea, china and cambodia, We confirmed PL showed two major protein bands, 50 kDa and 80 kDa by protein analysis. These PL effectively upregulated the expressions of IL-2 at 10 ug/ml and GM-CSF, IL-4, IL-10, IL-12(p35), IL-12(p40), IL-18, IFN-r in all concentrations. However, Korea-PL upregulated the expression of IL-12 more effectively than the other PLs. It intended to increase NO with no significance. Those results indicate Phellinus linteus had cytokine modulating effect
Bibliography:KISTI1.1003/JNL.JAKO200317140936729
ISSN:1738-7698
2288-2529
2283-2529