맹종죽의 항산화활성을 통한 항고혈압 효능

• Published in: 동의생리병리학회지 Vol. 21; no. 3; pp. 658 - 665
• Main Authors: 이혜숙(Hye Suk Lee), 박민희(Min Hee Park), 김정숙(Jung Suk Kim), 임병우(Beong Ou Lim), 문갑순(Gap Soon Moon), 신흥묵(Heung Mook Shin)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 2007
• Subjects: antioxidative effect; nagiotensin converting enzyme (ACE); tissue peroxidation; Phyllostachys pubescens extract (PPE)
• ISSN: 1738-7698; 2288-2529; 2283-2529

Phyllostachys pubescens (Maengiong-Juk), a kind of the bamboo, was reported to have many beneficial pharmacological actions. in this study, of using 70% ethanol extract of Phyllostachys pubescens we investigated its efficacy on angiotensin converting enzyme (ACE) and antioxidant enzyme activities. In addition, vasorelaxant effect was examined in rat aortic rings. The inhibitory effect of ACE activity by Phyllostachys pubescens extract (PPE) was dose-dependently increased by 61.42% at 10mg/ml. PPE relaxed the pre-contracted rat aortic rings with 10$^{-6}$M phenylephrine, showing about 88% at 4.0mg/ml. Sprague Dawley (SD) rats were given different concentrations of PPE mixed in the drinking water for 10 weeks. PPE did not show any difference with control group in blood pressure, body weight (BW) and food intake. However, it revealed the highest total antioxidative effect at dose of 1.0 g/100 g BW in plasma by TEAC assay. Thiobarbituric acid reactive substance (TBARS) and protein carbonyl levels which are markers of tissue peroxidation, were significantly lowed at the same dosage. Furthermore, hepatic antioxidant enzymes such as total superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and catalase activities were also significantly increased by PPE (1.0 g/100 g BW). In conclusion, we suggest that PPE might have antihypertensive effect through increasing antioxidant activities.