PCSK9과 LDL-C: 운동의 역할
PURPOSE: Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) is a pivotal regulator of low lipoprotein-cholesterol (LDL-C) and LDL receptor (LDLR) metabolism, and the interest in PCSK9 has increased in cardiovascular diseases. Exercise reduces blood LDL-C via PCSK9-LDLR pathway in the liver and th...
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| Published in | Exercise science (Seoul, Korea) pp. 347 - 351 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | Korean |
| Published |
한국운동생리학회
01.12.2020
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1226-1726 2384-0544 |
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| Summary: | PURPOSE: Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) is a pivotal regulator of low lipoprotein-cholesterol (LDL-C) and LDL receptor (LDLR) metabolism, and the interest in PCSK9 has increased in cardiovascular diseases. Exercise reduces blood LDL-C via PCSK9-LDLR pathway in the liver and the vasculature. However, the mechanism of exercise-induced inhibition of PCSK is unclear.
The aim of this review is to describe the role of exercise on PCSK9-LDLR axis in cardiovascular diseases.
METHODS: This study review 34 previous studies focusing on the effect of exercise on PCSK9 in the human and animal.
RESULTS: The effects of exercise and lifestyle intervention on hepatic and circulating PCSK9 are controversial. However, exercise consistently increases hepatic LDLR, and inhibits atherosclerosis via suppression of PCSK9 and LOX-1 in atherosclerotic region.
CONCLUSIONS: Even though experimental data are still very limited, exercise training can improves blood LDL-C via inhibition of PCSK9 and enhancement of LDLR in liver and vasculature. The study of exercise on PCSK9 are urgently needed. KCI Citation Count: 0 |
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| ISSN: | 1226-1726 2384-0544 |