천식 환자에서 집먼지진드기 감작 유무에 따른 임상적 차이: 순천향 코호트 분석

• Published in: Allergy asthma & respiratory disease pp. 50 - 54
• Main Authors: 김정현, 장안수, 정신옥, 지영석, 서현정, 남재형, 문종주, 백애린, 박종숙, 이준혁, 박성우, 김도진, 박춘식
• Format: Journal Article
• Language: Korean
• Published: 대한 소아알레르기 호흡기학회 31.03.2013
• Subjects: 소아과학
• ISSN: 2288-0402; 2288-0410

Purpose: The majority of patients with allergic disease are highly sensitized to house dust mites (HDM). There is few data to observe sensitization rate to HDM in asthmatics in Korea. The aim of this study was to observe the differences of clinical profiles by HDM sensitization in patients with asthmatics in Soonchunhyang University Hospital (SCH) cohort. Methods: We recruited 2,345 asthmatic patients in SCH cohort. Lung function, body mass index and sputum and blood eosinophils, and PC20, and clinical profiles were compared by HDM sensitization. Results: Dermatophagoides farinae (Derf) and/or Dermatophagoides pteronyssinus (Derp) (+) sensitization rate was higher prevalence in male than in female. Compared with nonatopy asthmatics, Derf and/or Derp (+) asthmatics had early onset of age [Derf and/or Derp (+) vs. Derf and Derp (-) vs. atopy (-); 32.5±0.51 vs. 36.1±0.88 vs. 43.1±0.54, P<0.05]. Derf and/or Derp (+) asthmatics had shorter duration of asthma symptom than that of nonatopy asthmatics. Derf and/or Derp (+) asthmatics had lower forced expiratory volume in one second and forced vital capacity than those of Derf and Derp (-) asthmatics. PC20 in Derf and/or Derp (+) asthmatics had lower than those of Derf and Derp (-) and nonatopy asthmatics [Derf and/or Derp (+) vs. Derf and Derp (-) vs. atopy (-); 5.4±0.24 mg/mL vs. 6.59±0.52 mg/mL vs. 7.19±0.33 mg/mL, P<0.05]. Blood eosinophils number in Derf and/or Derp (+) asthmatics had higher than that of nonatopy asthmatics (414.7±131.1 vs. 350.6±14.0, P<0.05). Total immunoglobulin E (IgE) in Derf and/or Derp positive asthmatics had higher than that of Derf and Derp negative and nonatopy asthmatics. There was no difference of body mass index among three groups. Conclusions: Our data indicate that atopy asthmatics sensitized to Derf and/or Derp had early onset of age, high total IgE and airway responsiveness, and eosinophilic inflammation. KCI Citation Count: 1