다발성 전이를 동반한 위 평활근육종

• Published in: The Korean journal of gastroenterology Vol. 65; no. 2; pp. 112 - 117
• Main Authors: 류우선, Woo Sun Rou, 주종석, Jong Seok Ju, 강선형, Sun Hyung Kang, 문희석, Hee Seok Moon, 성재규, Jae Kyu Sung, 이병석, Byung Seok Lee, 정현용, Hyun Yong Jeong, 송규상, Kyu Sang Song
• Format: Journal Article
• Language: Korean
• Published: 대한소화기학회 28.02.2015
• Subjects: Gastrointestinal; Immunohistochemistry; Leiomyosarcoma; Neoplasm metastasis; Stomach; 내과학
• ISSN: 1598-9992; 2233-6869

Leiomyosarcoma is an uncommon tumor that originates from various organs, including uterus, kidney, retroperitoneum, and soft tissues. In particular, leiomyosarcoma of the stomach is extremely rare. Only 9 cases have been reported worldwide since the discovery of KIT-activating mutation. A 48-year-old woman was admitted to our hospital with abdominal discomfort and generalized weakness. Upon detection of multiple nodules in both lung on chest posterior-anterior radiograph taken at the time of admission, chest CT was performed and it revealed multiple mass lesions in the lung, liver, and pancreas along with multiple lymph node metastases. On endoscopic examination, a 2.0 cm sized ulcerofungating mass lesion was found on the stomach body. Biopsy was performed and the mass lesion proved to be leiomyosarcoma confirmed by immunohistochemical staining. Chemotherapy was thus initiated, but the patient died after one year due to tumor progression. Our experience suggests that leiomyosarcoma can manifest aggressive behavior in its early stage. Herein, we report a case of gastric leiomyosarcoma with multiple metastases along with review of relevant literature.