복어 섭취 후 발생한 급성 테트로도톡신 중독 환자의 임상적 특징과 예후 인자 분석

• Published in: 대한임상독성학회지 Vol. 12; no. 2; pp. 46 - 53
• Main Authors: 조용수, Yong Soo Jo, 전병조, Byeong Jo Chun, 문정미, Jeong Mi Moon, 류현호, Hyun Ho Ryu, 정용훈, Yong Hun Jung, 이성민, Sung Min Lee, 송경환, Kyung Hwan Song, 류진호, Jin Ho Ryu
• Format: Journal Article
• Language: Korean
• Published: 대한임상독성학회 30.12.2014
• Subjects: Clinical feature; Prognostic factor; Puffer fish; Tetrodotoxin poisoning; Tetrodotoxin poisoning; Prognostic factor; Clinical feature; Puffer fish
• ISSN: 1738-1320; 2508-6332

Purpose: We conducted this study in order to determine clinical features and prognostic factors in adults with acute tetrodotoxin (TTX) poisoning caused by ingestion of puffer fish. Methods: In this retrospective study, 107 patients were diagnosed with TTX poisoning. The subjects were divided into two groups according to duration of treatment; Group I, patients were discharged within 48 hours (n=76, 71.0%), Group II patients were discharged after more than 48 hours (n=31, 29.0%). Group II was subsequently divided into two subgroups [IIa (n=12, 11.2%), IIb (n=19, 17.8%)] according to the need for mechanical ventilation support. Results: In multivariable logistic regression analysis, the predictors of the need for treatment over 48 hours were dizziness (odds ratio [OR], 4.72; 95% confidence intervals [CI], 1.59-12.83), time interval between onset of symptom and ingestion (OR, 0.56; 95% CI, 0.16-0.97), PaCO2<35 mmHg (OR, 8.37; 95% CI, 2.37-23.59). In addition, predictors of the need for mechanical ventilation were a time interval between onset of symptoms and ingestion (OR, 0.54; 95% CI, 0.11-0.96) and PaCO2<35 mmHg (OR, 5.65; 95% CI, 1.96-18.66). Conclusion: Overall, dizziness, time interval between onset of symptoms and ingestion, DBP and PaCO2<35 mmHg predict the need for treatment over 48 hours, time interval between onset of symptoms and ingestion and PaCO2<35 mmHg predict the need for mechanical ventilation support after acute TTX poisoning.