Steamed Ginseng Berry Powder Ameliorates Skeletal Muscle Atrophy via Myogenic Effects

• Published in: Journal of microbiology and biotechnology Vol. 34; no. 1; pp. 157 - 166
• Main Authors: Jungbum Kim, Hui-ji Choi, Donghyuk Seo, Sang-ah Lee, Jong Beom Heo, Dong Hyuk Baek, Wonhwa Lee, Gyu Yong Song
• Format: Journal Article
• Language: Korean
• Published: 한국미생물생명공학회 31.01.2024
• Subjects: myogenesis; Sarcopenia; skeletal muscle atrophy; steamed ginseng berry powder; Sarcopenia; myogenesis; skeletal muscle atrophy; steamed ginseng berry powder
• ISSN: 1017-7825; 1738-8872

Sarcopenia is an age-related loss of muscle mass and function for which there is no approved pharmacological treatment. We tested direct efficacy by evaluating grip strength improvement in a sarcopenia mouse model rather than drug screening, which inhibits specific molecular mechanisms. Various physiological functions of ginseng berries are beneficial to the human body. The present study aimed to evaluate the efficacy and safety of steamed ginseng berry powder (SGBP). SGBP administration increased myotube diameter and suppressed the mRNA expression of sarcopenia-inducing molecules. SGBP also reduced the levels of inflammatory transcription factors and cytokines that are known to induce sarcopenia. Oral administration of SGBP improved muscle mass and physical performance in a mouse model of sarcopenia. In summary, our data suggest that SGBP is a novel therapeutic candidate for the amelioration of muscle weakness, including sarcopenia.