미분화 척추관절증 환자의 임상상 ; 강직성 척추염 환자와의 비교

• Published in: The Korean journal of medicine Vol. 52; no. 1; pp. 42 - 48
• Main Authors: 이혜순, Hye Soon Lee, 김찬, Chan Kim, 박효숙, Hyo Sook Park, 임미경, Mi Kyoung Lim, 김홍자, Hong Ja Kim, 최승원, Seung Won Choi, 유빈, Bin Yoo, 문희범, Hee Bom Moon
• Format: Journal Article
• Language: Korean
• Published: 대한내과학회 01.01.1997
• Subjects: Ankylosing spondylitis; HLA B - 27; Undifferentiated spondyloarthropathy
• ISSN: 1738-9364

Objectives: To investigate the clinical features of undifferentiated spondyloarthropathy among the HLA-B27 positive arthralgic patients and to compare with those of ankylosing spondylitis. Methods: Two hundred and three HLA-B27 positive subjects among patients with arthralgia in various joints were classified according to the standard diagnostic criteria. The onset age, disease duration, numbers of involved joint, X-ray and bone scan findings were compared between patients with undifferentiated spondyloarthropathy(uSpA) and ankylosing spondylitis(AS). Results: 1) The patients diseases were classified as ankylosing spondylitis(46%), undifferentiated spondyloarthropathy(29%), juvenile spondyloarthropathy(4%), reactive arthritis(3%), psoriatic spondyloarthropathy(1%) and unclassified(17%). 2) In undifferentiated spondyloarthropathy, the durations of the symptoms were shorter than ankylosing spondylitis and the male predominance is less prominent(5; 1 as compared to 17:1 in ankylosing spondylitis). 3) The numbers of involved peripheral joints and the frequency of peripheral joint inflammation were more frequent in undifferentiated spondyloarthropathy while the spinal joint symptoms including sacroiliac joint and the radiological severity grade of sacroiliitis were higher in ankylosing spondylitis. 4) There were no significant differences in bone scan uptake and ESR between undifferentiated spondyloarthropathy and ankylosing spondylitis. Conclusion: The prevalence of undifferentiated spondyloarthropathy was notable high in HLA-B27- posicive arthralgic patients when a new classification criteria was applied, Attention should be paid on the diagnosis and progression of this elusive and challenging clinical entity.