Propofol 유도용량에 따른 심혈관계의 변화

• Published in: Korean journal of anesthesiology Vol. 30; no. 3; pp. 300 - 304
• Main Authors: 김교상, Kyo Sang Kim, 전민선, Min Seon Jeon, 서정국, Jung Kook Suh, 유희구, Hee Koo Yoo, 전세웅, Se Ung Chon
• Format: Journal Article
• Language: Korean
• Published: 대한마취통증의학회 30.03.1996
• Subjects: Anesthetics; hemodynamics; intravenous; propofol. Measurement techniques
• ISSN: 2005-6419

Background: Propofol(2,6 diisopropylphenol) is a potent hypnotic currently formulated as an oil-in-water emulsion. Although previous studies reported decreases in arterial pressures and heart rate, no detailed studies of hemodynamic effects of propofol administration alone are available in Korea. This study is to determine the hemodynamic changes induced by doses of propofol. Methods: Sixty patients(ASA physical status 1 or 2) were divided randomly into three groups as follows: group I, pmpofol 1.5 mg/kg; group 2, propofol 2.0 mg/kg; group 3, propofol 2.5 mg/kg. Heart rate and mean arterial pressure were measured by Datascope 2200I, and cardiac index(CI) and systemic vascular resistance index(SVRI) were obtained by doppler cardiac output monitor(Datascope Accucom 2) at the suprasternal notch before and after induction of propofol. Results: Statistically significant decreases in mean arterial pressure were observed since 2 min after induction. CI was decreased from 2.94±0.51 to 2.35±0.57 L/min/m² at 6 min after induction of propofol 2.5 mg/kg, and no differences among groups. CI was also decreased in group 1 and 2 but without any significance. SVRI was decreased in all groups but there were no significance, and no differences among groups. Conclusions: The data suggest that the usual doses of propofol do not significantly cause hemodynamic changes, and a decrease in mean arterial pressure is a result of decreased CI and reduced SVRI. (Korean J Anesthesiol 1996; 30: 300~304)