심장 이식 후에 발생한 침윤성 폐 Aspergillosis 2 예

• Published in: The Korean journal of medicine Vol. 53; no. 2; pp. 250 - 255
• Main Authors: 윤재형, Jae Hyung Yoon, 이수금, Su Geum Lee, 고경환, Kyung Whan Ko, 홍석근, Suk Keun Hong, 현민수, Min Su Hyon, 김명아, Myung A . Kim, 박성훈, Seong Hoon Park, 박국양, Guk Yang Park, 김희정, Hee Jung Kim, 오미혜, Mee Hye Oh
• Format: Journal Article
• Language: Korean
• Published: 대한내과학회 01.08.1997
• Subjects: Heart transplantation; Invasive aspergillosis
• ISSN: 1738-9364

Case 1: A 39-year-old man underwent orthotopic heart transplantation on November 1994 for dilated cardiomyopathy. His postoperative course was unevenful and medications included daily cyclosporin A, Immuran and prednisone. On December 13.1994, he developed cough and sore throat. Chest radiographs revealed multiple patch growing lesions. Sputum fungus culture revealed Aspergillus Fumigatus. The patient was treated with daily infusion of amphotericin B. He remains well without evidence of relapse of Aspergillus, Case 2: This 39-year-old man had undergone orthotopic heart transplantation on November 16 1994 for dilated cardiomyopathy. In December 7.1994. he developed recurrent syncope. Chest radiographs revealed fungus ball like lesion on right lung field. On open lung biopsy and wedge resection of the mass was performed. Aspergillosis and CMV infection was demonstrated in the biopsy specimen. The patient was treated with conventional amphotericin B therapy for over 7weeks and Ganciclovir for over 2weeks. At the end of therapy chest X-ray showed only small residual scar in the area of previous mass.