Cimetidine 을 복용중인 환자에서 발생한 급성 간질성 신염 1례

• Published in: The Korean journal of medicine Vol. 57; no. 5; pp. 941 - 945
• Main Authors: 김영옥, Young Ok Kim, 이승규, Seung Kyu Lee, 윤선애, Sun Ae Yoon, 방병기, Byung Kee Bang, 홍순화, Soon Hwa Hong, 하병화, Byung Hwa Ha, 이봉수, Bong Soo Lee, 이은정, Eun Jung Lee
• Format: Journal Article
• Language: Korean
• Published: 대한내과학회 01.11.1999
• Subjects: Acute interstitial nephritis; Acute renal failure; Cimetidine
• ISSN: 1738-9364

Although cimetidine causes a transient rise in serum creatinine without reduction of renal function, acute renal failure due to acute interstitial nephritis is rare in patients after cimetidine treatment. We here present a case of acute renal failure and acute interstitial nephritis that occurred during cimetidine treatment. A 38-year old woman was referred to our hospital because of nausea and general weakness. She had been taking cimetidine for 3 weeks because of epigasric discomfort. On admission, serum creatinine was 3.9 mg/dL and urinalysis showed mild proteinuria and hematuria. There was no history of pyelonephritis, diabetes mellitus, hypertension, toxin exposure. Renal biopsy showed severe interstitial infiltration of lymphocytes without definite glomerular change. After withdrawal of cimetidine, renal function completely recovered. (Korean. J. Med 57:941-945, 1999)