소화성 궤양에 있어서 혈청 Pepsinogen I 의 의의에 관한 연구

• Published in: The Korean journal of medicine Vol. 49; no. 1; pp. 14 - 19
• Main Authors: 이선희, Sun Hee Lee, 이동필, Dong Pil Lee, 신영민, Young Min Sin, 황성윤, Sung Yoon Hwang, 송근암, Kun Am Song, 조몽, Mong Cho, 양웅석, Ung Suk Yang, 문한규, Han Kyu Moon
• Format: Journal Article
• Language: Korean
• Published: 대한내과학회 01.07.1995
• Subjects: Helicobacter pylori; Pepsinogen I; Peptic ulcer
• ISSN: 1738-9364

Objectives: Peptic ulcer is heterogenous disease which has genetic or acquired etiologic factors and serum pepsinogen I (PG I) was reported as a marker of the genetic factor. In this study, the correlations of serum PG I level and natural course of peptic ulcer disease such as site, stage, recurrence and acquired factors such as smoking, H. pylori were evaluated. Methods: Fasting serum PG I levels were tested in 71 patients with peptic ulcer (Gastric ulcer 31, Duodenal ulcer 40) who had been confirmed by endoscopy, biopsy and 58 healthy control from January, 1991 to August, 1993 at Pusan National University Hospital. Serum PG I levels between ulcer and control group were compared and correlations of serum PG I level and natural course such as site, stage, complicaton, recurrence and acquired factors such as smoking, NSAID, H. pylori in ulcer group were observed. Results : 1) The patients with peptic ulcer showed significantly higher mean levels of serum PG I than those of the control group. Especially the mean levels of PG I of antral ulcer and duodenal ulcer were higher than ulcer of gastric body and angle. 2) The patients with active ulcer showed higher mean levels of serum PG I than healing stage ulcer. but there weas no statistical significance. 3) The patients with recurrence, smoking history, complications showed higher mean levels of PG I than those without recurrence, smoking history, complications. but there was no statistical significance. 4) The CLO test positive group of the duodenal ulcer patients showed higher mean levels of serum PG I than those of CLO test negative group. but there was no statistical significance. Conclusion: The above results suggest that serum pepsinogen I may be useful as a parameters of activity and recurrence and as a subclinical markers for acquired risk factors of the peptic ulcer.