단순정맥압박검사에 의한 혈액내 FDP ( fibrinogen degradation produc ) 농도 변화를 이용한 인슐린비의존성 당뇨병환자와 뇌졸중환자의 대혈관기능 이상 진단

• Published in: The Korean journal of medicine Vol. 56; no. 5; pp. 613 - 619
• Main Authors: 김상훈, Sang Hoon Kim, 심성춘, Sung Chun Sim, 장남수, Nam Soo Jang, 박창영, Chang Young Park, 최윤상, Young Sang Choi, 이규백, Kyu Beck Lee, 강진호, Jin Ho Kang, 김향, Hang Kim, 조윤경, Yoon Kyung Cho, 김유리, Yoo Lee Kim, 이상종, Sang Jong Lee
• Format: Journal Article
• Language: Korean
• Published: 대한내과학회 01.05.1999
• Subjects: Cerebrovascular accident; Fibrinogen degradation product; Macroangiopathy; Non-insulin dependent diabetes mellitus; Venous occlusion test
• ISSN: 1738-9364

Objectives : In diabetic patients, the incidence of atherosclerotic disease are increased, which may be due to decreased fibrinolytic activity. The aim of study is to elucidate the relationship between angiopathies and vascular function evaluated by simplified venous occlusion test in patients with non-insulin dependent diabetes mellitus (NIDDM) and cerebrovascular accident (CVA). Methods : The study was conducted on 63 patients who were hospitalized during the period from March 1, 1994 to May 30, 1997. The serum concentration of fibrinogen degradation products (FDP) was measured before and 5 min after venous occlusion in 31 NIDDM patients, 16 CVA patients and 16 age-matched control subjects. FDP was measured with the anti-fibrinogen- coated latex particle agglutinin assay system. Results : 1) The basal serum FDP level was higher in diabetic patients with macroangiopathy (12.3±5.8 ug/ml) and patients with CVA (11.2±5.1 ug/ml) than in control subjects (5.7±1.8 ug/ml) (p<0.05). 2) The increment of serum FDP level after venous occlusion in diabetic patients with microangiopathy (6.6±2.2 to 10.3±4.1 ug/ml) and control subjects (5.7±1.8 to 11.4±4.3 ug/ml) was significantly higher than basal serum FDP level (p<0.05). But the increment of serum FDP level after venous occlusion in diabetic patients with macroangiopathy (12.3±5.8 to 15.2±5.1 ug/ml) and patients with CVA (11.2±5.1 to 13.7±4.8 ug/ml) wasn't significantly higher than basal serum FDP level. 3) The increment rate of serum FDP after venous occlusion in diabetic patients with macroangiopathy (24.4±29.3%) and patients with CVA (29.4±34.5%) was significantly lower than diabetic patients with microangiopathy (66.3±71.7%) and control subjects (84.1±69.3%) (p<0.05). Conclusion : The responsiveness of fibrinolytic activity to venous occlusion was significantly lower in diabetic patients with macroangiopathy, as in patients with CVA, compared with that in control subjects. We conclude that measurement of the increase in serum FDP concentration 5 min after venous occlusion may be useful to detect vascular dysfunction in patients with macrovascular disease caused by atherosclerosis.