고양이에서 Lidocaine 의 점적 주입이 Succinylcholine 이 Vecuronium 의 근이완 작용에 미치는 영향

• Published in: Korean journal of anesthesiology Vol. 25; no. 5; pp. 955 - 961
• Main Authors: 신양식, Yang Sik Shin, 김명희, Myoung Hee Kim, 이기영, Ki Young Lee, 문봉기, Bong Gi Moon, 곽영란, Yung Lan Kwak, 김종래, Jong Rae Kim, 박광원, Kwang Won Park
• Format: Journal Article
• Language: Korean
• Published: 대한마취통증의학회 30.10.1992
• Subjects: Drug interaction; Lidocaine; Succinylcholine; Vecuronium
• ISSN: 2005-6419

The effect of lidocaine on the neuromuscular junction and the interaction between lidocaine and the muscle relaxant, succinylcholine(SCC) or vecuronium(VEC), were investigated in 12 cats of either sex using the sciatic nerve-anterior tibialis muscle preparation. The degree of twitch depression with lidocaine itself was 16.43±14.94%, and the ED from dose-response curves of SCC and VEC(8.35±4.62 and 6.36±8.03 μg/kg, respectively) in group II (under lidocaine infusion) were smaller than those(20.57±15.80 and 8.98±7.31 μg/kg) in group I (without lidocaine). There was no difference in the duration of action of SCC and VEC between the two groups, but the onset of VEC in group II was longer than in group I(p<0.05), The mean arterial pressure(MAP) after lidocaine infusion was reduced 149.17 to 130.83mmHg and MAPs at the same dose of each agent were also lower in group II than in group L The authors conclude that lidocaine itself produces the twitch depression and potentiates the SCC-or VEC-induced neuromuscular block. However, there is no influence on the duration of SCC or VEC.