D-galactosamine/lipopolysaccharide로 감작된 급성간독성 마우스 모델에서 인삼열매추출물의 간독성 개선 효과

• Published in: Han'guk Sikp'um Kwahakhoe Chi = Korean Journal of Food Science and Technology Vol. 49; no. 6; pp. 676 - 684
• Main Authors: 장수길(Su Kil Jang), 박준섭(Jun Sub Park), 안정원(Jeong Won Ahn), 조보람(Boram Jo), 김현수(Hyun Soo Kim), 김정훈(JeongHoon Kim), 김상윤(Sang Yun Kim), 박정열(Jung Youl Park), 이도익(Do Ik Lee), 박희용(Hee Yong Park), 주성수(Seong Soo Joo)
• Format: Journal Article
• Language: Korean
• Published: Seoul 한국식품과학회 01.12.2017; Korean Society of Food Science & Technology
• Subjects: Alanine; Alanine transaminase; Alkaline phosphatase; Animal models; Aspartate aminotransferase; Chemical compounds; Cytokines; D-Galactosamine; Damage prevention; Ethanol; Fruits; Ginseng; Ginsenosides; L-Lactate dehydrogenase; Lactate dehydrogenase; Lactic acid; Linoleic acid; Lipopolysaccharides; Liver; Mice; Organs; Pharmacology; Rodents; Toxicity; Tumor necrosis factor-α; 식품과학; ginsenoside; linoleic acid; D-galactosamine/lipopolysaccharide; non-alcoholic fatty liver disease; ginseng berry; text\tiny{D}$-galactosamine/lipopolysaccharide
• ISSN: 0367-6293; 2383-9635
• DOI: 10.9721/KJFST.2017.49.6.676

The present study aimed to examine the hepatoprotective effects of ethanol extracts from steam-dried ginseng berry (SGBE) in both D-Galactosamine/Lipopolysaccharide (D-GalN/LPS)-sensitized mice and in vitro models. Our results clearly demonstrated that SGBE significantly reduced the level of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and lactate dehydrogenase in blood, and TNFα was normalized in 8 h after the treatment with DGalN/LPS. Coincidently, major organs remained unimpaired when compared to D-GalN/LPS control group. Moreover, p38, which stimulates expression of NAFLD-associated cytokines, was markedly inhibited when treated with SGBE. In vitro analysis revealed that the main components of SGBE, linoleic acid and ginsenoside Re/Rd, may play a role in protecting liver from D-GalN/LPS-induced toxicity. Finally, we concluded that SGBE may be a promising therapeutic agent for preventing damage to the liver.