Aβ42로 유도된 알츠하이머 마우스 모델에서 이중 가공 인삼열매 추출물의 학습 및 기억 손실 개선 효과

• Published in: Han'guk Sikp'um Kwahakhoe Chi = Korean Journal of Food Science and Technology Vol. 51; no. 2; pp. 160 - 168
• Main Authors: 장수길(Su Kil Jang), 안정원(Jeong Won Ahn), 조보람(Boram Jo), 김현수(Hyun Soo Kim), 김서진(Seo Jin Kim), 성은아(Eun Ah Sung), 이도익(Do Ik Lee), 박희용(Hee Yong Park), 진덕희(Duk Hee Jin), 주성수(Seong Soo Joo)
• Format: Journal Article
• Language: Korean
• Published: Seoul 한국식품과학회 01.04.2019; Korean Society of Food Science & Technology
• Subjects: Acetylcholinesterase; Acetyltransferase; Alzheimer's disease; Brain damage; Brain injury; Choline; Choline O-acetyltransferase; Cognitive ability; Damage detection; Fruits; Ginseng; Ginsenosides; Glial fibrillary acidic protein; Learning; Memory; Model testing; Neurodegenerative diseases; Signs and symptoms; 식품과학; passive avoidance test; Morris water-maze test; choline acetyltransferase; acetylcholine; processed ginseng berry extract
• ISSN: 0367-6293; 2383-9635
• DOI: 10.9721/KJFST.2019.51.2.160

This study aimed to determine whether double-processed ginseng berry extract (PGBC) could improve learning and memory in an Aâ42-induced Alzheimer's mouse model. Passive avoidance test (PAT) and Morris water-maze test (MWMT) were performed after mice were treated with PGBC, followed by acetylcholine (ACh) measurement and glial fibrillary acidic protein (GFAP) detection for brain damage. Furthermore, acetylcholinesterase (AChE) activity and choline acetyltransferase (ChAT) expression were analyzed using Ellman's and qPCR assays, respectively. Results demonstrated that PGBC contained a high amount of ginsenosides (Re, Rd, and Rg3), which are responsible for the clearance of Aâ42. They also helped to significantly improve PAT and MWMT performance in the Aâ42-induced Alzheimer's mouse model when compared to the normal group. Interestingly, ACh and ChAT were remarkably upregulated and AChE activities were significantly inhibited, suggesting PGBC to be a palliative adjuvant for treating Alzheimer's disease. Altogether, PGBC was found to play a positive role in improving cognitive abilities. Thus, it could be a new alternative solution for alleviating Alzheimer's disease symptoms.