꿀벌 꽃가루 열수 추출물의 수지상 세포 활성화 및 Th1 반응에 미치는 효과

• Published in: Han'guk Sikp'um Kwahakhoe Chi = Korean Journal of Food Science and Technology Vol. 50; no. 4; pp. 444 - 450
• Main Authors: 조은지(Eun-Ji Cho), 김이은(Yi-Eun Kim), 변의홍(Eui-Hong Byun)
• Format: Journal Article
• Language: Korean
• Published: Seoul 한국식품과학회 01.08.2018; Korean Society of Food Science & Technology
• Subjects: Adaptive immunity; Antigen-presenting cells; Bone marrow; CD80 antigen; CD86 antigen; Cell activation; Dendritic cells; IL-1β; Immune response; Immune system; Immunity; Immunomodulation; Inflammation; Interferon; Interleukin 6; Interleukins; Lymphocytes T; Major histocompatibility complex; Mice; Polarization; Pollen; Splenocytes; Toxicity; Tumor necrosis factor-TNF; Tumor necrosis factor-α; 식품과학; cytokine production; dendritic cells; splenocyte; immunomodulatory activity; bee pollen
• ISSN: 0367-6293; 2383-9635
• DOI: 10.9721/KJFST.2018.50.4.444

Dendritic cells (DCs) are potent antigen-presenting cells that play a pivotal role in modulating both innate and adaptive immunity. This study examined the immunomodulatory activities of hot-water extracts of bee pollen (BPW) in bone-marrow derived DCs (BMDC) and mice splenocytes. BMDCs isolated from mice were treated with 250 and 500 μg/mL BPW for 24 h. BPW, up to 500 μg/mL, did not display any cellular toxicity against BMDCs. In fact, it functionally induced BMDC activation via augmentation of CD80, CD86, and major histocompatibility complex (MHC) class I/II expression and pro-inflammatory cytokine (tumor necrosis factor; TNF-α, interleukin; IL-6, and IL-1β) production. Interestingly, BPW treatment significantly increased the production of interferon (IFN)-γ in splenocytes, suggesting its possible contribution to Th1 polarization in immune response. Taken together, these findings suggest that BPW may regulate innate and adaptive immunity via DC activation and Th1 polarization in immune responses.