Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia

• Published in: Journal of Medicinal Chemistry Vol. 65; pp. 135 - 162
• Main Authors: Caiping Liu, Jingxuan Han, Olivia Marcelina, Dyah Ari Nugrahaningrum, Song Huang, Meijuan Zou, Guixue Wang, Makoto Miyagishi, Yun He, Shourong Wu, Vivi Kasim
• Format: Journal Article
• Language: Japanese
• Published: American Chemical Society (ACS) 23.12.2021
• Subjects: 1α protein; Angiogenesis Inducing Agents; angiogenic factors; angiogenic potential; Animals; based therapeutic strategy; better efficacy; Biochemistry; Cancer; Cell Biology; Chemical Sciences not elsewhere classified; clinical level; derivated glycoside analogues; Diabetes Mellitus, Experimental; druggable angiogenesis agent; functional blood vessels; Genetics; Glucosides; Glycosides; hind limb ischemia; Hindlimb; hli; however; inducible factor; Ischemia; Male; Medicine; Mice; Mice, Inbred C57BL; Molecular Biology; molecule drugs capable; natural glycosidic compound; Neovascularization, Pathologic; nondiabetic hli mice; novel angiogenesis agents; paracrine functions; Pharmacology; Phenols; Physiology; potential therapeutic strategy; Rats; Rats, Sprague-Dawley; skeletal muscle cells; skeletal muscle induces; smooth muscle cells; Space Science; treating hli; turn significantly increased; vascular endothelial
• ISSN: 0022-2623; 1520-4804
• DOI: 10.1021/acs.jmedchem.1c00947