Association between serum urate levels and food group intake in a community-based population: The Yamagata study

• Published in: Gout and Uric & Nucleic Acids Vol. 46; no. 1; pp. 45 - 52
• Main Authors: Suzuki, Natsuko, Ueno, Yoshiyuki, Imaeda, Nahomi, Watanabe, Masafumi, Goto, Chiho, Otaki, Yoichiro, Yaguchi, Yuri, Konta, Tsuneo
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Gout and Uric & Nucleic Acids 25.07.2022; 一般社団法人 日本痛風・尿酸核酸学会
• Subjects: Cohort study; Food; Serum urate; コホート研究; 血清尿酸; 食品
• ISSN: 2435-0095
• DOI: 10.14867/gnamtsunyo.46.1_45

This study examined the association between serum urate levels and food group intake among community-based health checkup participants. The study subjects were 12,443 individuals (5,647 men and 6,796 women; mean age: 63 years) who had completed a short food frequency questionnaire and had serum urate level data from 2009 to 2015. The association between serum urate levels at the time of the health checkup and daily intake (g/day) of 19 food groups based on the Food Intake Frequency Survey was analyzed separately for men and women. The mean serum urate acid level was 5.8±1.3 mg/dL in men and 4.5±1.0 mg/dL in women. Multiple regression analysis adjusted for background factors (age, BMI, and eGFR) revealed that serum urate levels in men showed a significantly positive correlation with alcohol and seafood and a significantly negative correlation with dairy products, bread, rice, and confectionery. In women, serum urate levels showed a significantly positive correlation with seafood and noodles and a significantly negative correlation with soybean and dairy products. Similarly, multivariate logistic regression analysis adjusted for the background factors showed that the odds ratio for hyperuricemia (>7.0 mg/dL) increased with seafood and alcohol and decreased with rice, coffee, bread, and dairy products in men, and decreased with coffee in women. These results suggest that the intake of various food groups is associated with serum urate levels independently of physical factors, and that the association differs in some parts between men and women in community populations.