Effectiveness of the administration of Dapagliflozin 10 mg for acute exacerbation of recurrent refractory chronic heart failure

• Published in: JAPANESE JOURNAL OF HOSPITAL GENERAL MEDICINE Vol. 19; no. 3; pp. 184 - 189
• Main Authors: Satoh, Hiroshi, Nagami, Haruhiko, Seshimo, Tatsuyuki, Tabara, Hideki
• Format: Journal Article
• Language: Japanese
• Published: JAPAN SOCIETY OF HOSPITAL GENERAL MEDICINE 31.05.2023; 一般社団法人 日本病院総合診療医学会
• Subjects: SGLT2阻害剤; 心筋保護; 慢性心不全
• ISSN: 2185-8136; 2758-7878
• DOI: 10.60227/jhgmwabun.19.3_184

Sodium glucose cotransporter 2 inhibitor is an anti-diabetic drug that is reported to be effective for elderly patients with chronic heart failure under reduced cardiac ejection fraction (HFrEF).We experienced the case of a 72-year old man with HFrEF whose cardiac function represented by serum BNP value and Ejection Fraction by echocardiography was improved after oral administration of Dapagliflozin 10mg after acute phase therapy.The precise mechanism of the effectiveness of Dapagliflozin for cardiac function is speculated to be improvement of cardiac energic metabolism by the increased use of ketone body, cardiac protection by inhibition of sympathetic nerve function, and improvement of cardiac remodeling represented by cardiac mass weight.Dapagliflozin was effective in the treatment of this elderly patient with chronic heart failure (HFrEF).