胆汁うっ滞症におけるグルカゴン投与後のcyclic AMPの応答性
肝内胆汁うっ滞症6例にグルカゴンを1μg/kg経静脈的に投与し血漿c-AMPの経時的推移を観察した.早朝空腹時の血漿c-AMP濃度は有意に高く,グルカゴン負荷後の血漿c-AMPの応答性も肝内胆汁うっ滞症では高応答性が明らかであった.in situ肝灌流装置によりグルカゴン1.92ng/min.持続注入によるc-AMPの応答性は胆管を結紮しても無処置ラットと差はなく,ethynyl estradiol 5mg/kg投与5日後のラットは高応答性を示した.以上の成績から肝内胆汁うっ滞症でのグルカゴン負荷後の血漿c-AMPの高応答性は胆道路の遮断によるc-AMPの血中への逆流の結果ではなく,胆汁うっ滞...
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| Published in | 肝臓 Vol. 23; no. 3; pp. 285 - 289 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本肝臓学会
25.03.1982
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0451-4203 1881-3593 |
| DOI | 10.2957/kanzo.23.285 |
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| Abstract | 肝内胆汁うっ滞症6例にグルカゴンを1μg/kg経静脈的に投与し血漿c-AMPの経時的推移を観察した.早朝空腹時の血漿c-AMP濃度は有意に高く,グルカゴン負荷後の血漿c-AMPの応答性も肝内胆汁うっ滞症では高応答性が明らかであった.in situ肝灌流装置によりグルカゴン1.92ng/min.持続注入によるc-AMPの応答性は胆管を結紮しても無処置ラットと差はなく,ethynyl estradiol 5mg/kg投与5日後のラットは高応答性を示した.以上の成績から肝内胆汁うっ滞症でのグルカゴン負荷後の血漿c-AMPの高応答性は胆道路の遮断によるc-AMPの血中への逆流の結果ではなく,胆汁うっ滞症による肝細胞の膜変化がグルカゴンに対して高応答性を示すようになることが示唆された. |
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| AbstractList | 肝内胆汁うっ滞症6例にグルカゴンを1μg/kg経静脈的に投与し血漿c-AMPの経時的推移を観察した.早朝空腹時の血漿c-AMP濃度は有意に高く,グルカゴン負荷後の血漿c-AMPの応答性も肝内胆汁うっ滞症では高応答性が明らかであった.in situ肝灌流装置によりグルカゴン1.92ng/min.持続注入によるc-AMPの応答性は胆管を結紮しても無処置ラットと差はなく,ethynyl estradiol 5mg/kg投与5日後のラットは高応答性を示した.以上の成績から肝内胆汁うっ滞症でのグルカゴン負荷後の血漿c-AMPの高応答性は胆道路の遮断によるc-AMPの血中への逆流の結果ではなく,胆汁うっ滞症による肝細胞の膜変化がグルカゴンに対して高応答性を示すようになることが示唆された. |
| Author | 吉田, 隆雄 松嶋, 喬 前久保, 博士 種田, 裕昭 宮崎, 保 |
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| References | 1) Maekubo H, Matsushima T, Okada F, et al: Anomalous plasma cyclic AMP responses to glucagon in patients with liver disease. Dig Dis Sci 25: 700-704, 1980 2) Maekubo H, Matsushima T, Miyazaki T, et al: Plasma cyclic adenosine-3', 5'-monophosphate response to glucagon in hepatic disease. Jap J Med 20: 11-15, 1981 6) Exton JH, Park CR: Control of gluconeogenesis in liver. J Biol Chem 242: 2622-2636, 1967 3) Davies TF, Prudhoe K, Douglas AP, et al: Plasma cyclic adenosine-3', 5'-monophosphate response to glucagon in patients with liver disease. Brit Med J 1: 931-933, 1976 7) Maekubo H, Moriya K, Hiroshige T, et al: Role of Keton bodies in nonshivering thermogenesis in cold-acclimated rats. J Appl Physiol 42: 159-165, 1977 8) Davis RA, Kern F Jr, Showalter R, et al: Alterations of hepatic (Na+-K+) ATPase and bile flow by estrogen. Effects on liver surface membrane lipid structure and function. Proc Natl Acad Sci USA 75: 4130-4134, 1978 4) Francavilla A, Pansini F, Sansone F, et al: Effect of glucagon infusion on plasma cyclic AMP in patients with cholestatic hepatitis and obstructive jaundice. New test of hepatic cholestasis. Clin Chim Acta 75: 351-357, 1977 5) Mortimore GE: Effect of insulin on release of glucose and urea by isolated rat liver. Am J Physiol 204: 699-704, 1963 |
| References_xml | – reference: 2) Maekubo H, Matsushima T, Miyazaki T, et al: Plasma cyclic adenosine-3', 5'-monophosphate response to glucagon in hepatic disease. Jap J Med 20: 11-15, 1981 – reference: 7) Maekubo H, Moriya K, Hiroshige T, et al: Role of Keton bodies in nonshivering thermogenesis in cold-acclimated rats. J Appl Physiol 42: 159-165, 1977 – reference: 4) Francavilla A, Pansini F, Sansone F, et al: Effect of glucagon infusion on plasma cyclic AMP in patients with cholestatic hepatitis and obstructive jaundice. New test of hepatic cholestasis. Clin Chim Acta 75: 351-357, 1977 – reference: 1) Maekubo H, Matsushima T, Okada F, et al: Anomalous plasma cyclic AMP responses to glucagon in patients with liver disease. Dig Dis Sci 25: 700-704, 1980 – reference: 3) Davies TF, Prudhoe K, Douglas AP, et al: Plasma cyclic adenosine-3', 5'-monophosphate response to glucagon in patients with liver disease. Brit Med J 1: 931-933, 1976 – reference: 5) Mortimore GE: Effect of insulin on release of glucose and urea by isolated rat liver. Am J Physiol 204: 699-704, 1963 – reference: 6) Exton JH, Park CR: Control of gluconeogenesis in liver. J Biol Chem 242: 2622-2636, 1967 – reference: 8) Davis RA, Kern F Jr, Showalter R, et al: Alterations of hepatic (Na+-K+) ATPase and bile flow by estrogen. Effects on liver surface membrane lipid structure and function. Proc Natl Acad Sci USA 75: 4130-4134, 1978 |
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| SubjectTerms | 胆汁うっ滞 高応答性 |
| Title | 胆汁うっ滞症におけるグルカゴン投与後のcyclic AMPの応答性 |
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