Retrospective Study on the Relationship Between the Recovery Rate of Bronchoalveolar Lavage Fluid and Sedation During Bronchoalveolar Lavage at Our Hospital

• Published in: The Journal of the Japan Society for Respiratory Endoscopy Vol. 46; no. 1; pp. 13 - 19
• Main Authors: Hiraoka, Noriya, Yuba, Tatsuya, Shiotsu, Shinsuke, Takumi, Chieko, Yamamoto, Kohei, Goda, Shiho, Tsuji, Taisuke, Tanaka, Shunya, Sasakura, Misaki
• Format: Journal Article
• Language: Japanese
• Published: The Japan Society for Respiratory Endoscopy 25.01.2024; 特定非営利活動法人 日本呼吸器内視鏡学会
• Subjects: Bronchoalveolar lavage; Bronchoalveolar lavage fluid; Recovery rate; Sedation; 回収率; 気管支肺胞洗浄; 気管支肺胞洗浄液; 鎮静
• ISSN: 0287-2137; 2186-0149
• DOI: 10.18907/jjsre.46.1_13

Background. In Japan, only 37% of facilities regularly use sedatives during bronchoalveolar lavage (BAL). The effects of sedative use on the bronchoalveolar lavage fluid (BALF) recovery rate and complications are not clear. We conducted this study to determine whether the use of sedatives, particularly fentanyl (FNT), in BAL increases the recovery of BALF. Subjects and Methods. A total of 180 patients received BAL at our hospital from July 1, 2019 to June 30, 2021. Patients were divided into the non-sedative-use, midazolam (MDZ), and MDZ+FNT groups. The BALF recovery rate, sedative use, and complications were retrospectively examined using medical records. Results. The eligible patients were classified into the three groups as follows: non-sedative-use (n=19), MDZ (n=101), and MDZ+FNT (n=60). There were no significant differences in patient backgrounds, and no complications were observed in any of the groups. There were no significant differences in the BALF recovery rates among the three groups; however, the BALF recovery rate in the MDZ+FNT group tended to be higher in comparison to the non-sedative-use group and the MDZ group. The MDZ+FNT group received significantly less MDZ than the MDZ group. Conclusion. The use of sedatives, especially MDZ+FNT, during BAL may improve the BALF recovery rate without increasing complications.