Search for novel diagnostic markers of chronic kidney disease in cats using proteome analysis

Feline kidney disease is increasing in clinical practice. Staging of chronic kidney disease follows the criteria of the International Renal Interest Society (IRIS); i.e., based on plasma creatinine and symmetric dimethylarginine (SDMA). Plasma creatinine is affected by non-renal factors, including g...

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Published inJOURNAL OF JAPANESE ASSOCIATION OF VETERINARY NEPHROLOGY AND UROLOGY Vol. 15; no. 1; pp. 17 - 21
Main Author SHIMIZU, Momori
Format Journal Article
LanguageJapanese
Published JAPANESE ASSOCIATION OF VETERINARY NEPHROLOGY AND UROLOGY 29.02.2024
日本獣医腎泌尿器学会
Subjects
Apolipoprotein A-IV
シアル酸化糖タンパク質
血漿
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ISSN1883-2652
2434-0146
DOI10.24678/javnu.15.1_17

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Summary:Feline kidney disease is increasing in clinical practice. Staging of chronic kidney disease follows the criteria of the International Renal Interest Society (IRIS); i.e., based on plasma creatinine and symmetric dimethylarginine (SDMA). Plasma creatinine is affected by non-renal factors, including gender, age and muscle mass, whereas SDMA is known to increase after loss of >40% of glomerular filtration rate. In this study, we examined plasma glycoproteins as early diagnostic markers for chronic kidney disease and identified fucosylated apolipoprotein A-IV as such a marker.
ISSN:1883-2652
2434-0146
DOI:10.24678/javnu.15.1_17