生物学的モニタリングのための血漿および赤血球膜リン脂質中長鎖多価不飽和脂肪酸の比較
「はじめに」多価不飽和脂肪酸(PUFA)は, 炭素鎖中の二重結合の位置によって大きくn-3およびn-6に分類される. n-3PUFAには, α-リノレン酸(α-LNA; 18:3n-6), エイコサペンタエン酸(EPA; 20:5n-3), ドコサヘキサエン酸(DHA; 22:6n-3)等が, n-6PUFAには, リノール酸(18:2n-6), ジホモγ-リノレン酸(20:3n-6), アラキドン酸(AA; 20:4n-6)等が存在する. n-3およびn-6系脂肪酸の中でも, 炭素数20以上, 二重結合3個以上のものを長鎖多価不飽和脂肪酸(LCPUFA)といい, これは細胞膜リン脂質(PL)...
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| Published in | 日本衛生学雑誌 Vol. 66; no. 1; pp. 108 - 114 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | Japanese |
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一般社団法人日本衛生学会
01.01.2011
日本衛生学会 |
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| Online Access | Get full text |
| ISSN | 0021-5082 1882-6482 |
| DOI | 10.1265/jjh.66.108 |
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| Abstract | 「はじめに」多価不飽和脂肪酸(PUFA)は, 炭素鎖中の二重結合の位置によって大きくn-3およびn-6に分類される. n-3PUFAには, α-リノレン酸(α-LNA; 18:3n-6), エイコサペンタエン酸(EPA; 20:5n-3), ドコサヘキサエン酸(DHA; 22:6n-3)等が, n-6PUFAには, リノール酸(18:2n-6), ジホモγ-リノレン酸(20:3n-6), アラキドン酸(AA; 20:4n-6)等が存在する. n-3およびn-6系脂肪酸の中でも, 炭素数20以上, 二重結合3個以上のものを長鎖多価不飽和脂肪酸(LCPUFA)といい, これは細胞膜リン脂質(PL)の構成成分となり, エイコサノイドの前駆体として炎症反応制御の他, 細胞の機能維持に関わることが知られている(1, 2). 従来から, 食事によるn-3LCPUFA摂取の生体指標として, ガスクロマトグラフィーによる血液中のEPA, DHA濃度の測定が行われてきている(3). |
|---|---|
| AbstractList | 「はじめに」多価不飽和脂肪酸(PUFA)は, 炭素鎖中の二重結合の位置によって大きくn-3およびn-6に分類される. n-3PUFAには, α-リノレン酸(α-LNA; 18:3n-6), エイコサペンタエン酸(EPA; 20:5n-3), ドコサヘキサエン酸(DHA; 22:6n-3)等が, n-6PUFAには, リノール酸(18:2n-6), ジホモγ-リノレン酸(20:3n-6), アラキドン酸(AA; 20:4n-6)等が存在する. n-3およびn-6系脂肪酸の中でも, 炭素数20以上, 二重結合3個以上のものを長鎖多価不飽和脂肪酸(LCPUFA)といい, これは細胞膜リン脂質(PL)の構成成分となり, エイコサノイドの前駆体として炎症反応制御の他, 細胞の機能維持に関わることが知られている(1, 2). 従来から, 食事によるn-3LCPUFA摂取の生体指標として, ガスクロマトグラフィーによる血液中のEPA, DHA濃度の測定が行われてきている(3). |
| Author | 黒川, 修行 村田, 勝敬 佐藤, 洋 柳沼, 梢 川端, 輝江 萩原, 千絵 仲井, 邦彦 |
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| References | (15) Popp-Snijders C, Schouten JA, de Jong AP, van der Veen EA. Effect of dietary cod-liver oil on the lipid composition of human erythrocyte membranes. Scand J Clin Lab Invest. 1984;44:39-46. (3) Arab L, Akbar J. Biomarkers and the measurement of fatty acids. Public Health Nutr. 2002;5:865-871. (27) Uauy R, Mena P, Wegher B, Nieto S, Salem N Jr. Long chain polyunsaturated fatty acid formation in neonates: effect of gestational age and intrauterine growth. Pediatr Res. 2000;47:127-135. (10) Sarkadi-Nagy E, Wijendran V, Diau GY, Chao AC, Hsieh AT, Turpeinen A, Lawrence P, Nathanielsz PW, Brenna JT. Formula feeding potentiates docosahexaenoic and arachidonic acid biosynthesis in term and preterm baboon neonates. J Lipid Res. 2004;45:71-80. (32) Nakajima S, Saijo Y, Kato S, Sasaki S, Uno A, Kanagami N, Hirakawa H, Hori T, Tobiishi K, Todaka T, Nakamura Y, Yanagiya S, Sengoku Y, Iida T, Sata F, Kishi R. Effects of prenatal exposure to polychlorinated biphenyls and dioxins on mental and motor development in Japanese children at 6 months of age. Environ Health Perspect. 2006;114:773-778. (13) Holub BJ, Wlodek M, Rowe W, Piekarski J. Correlation of omega-3 levels in serum phospholipid from 2053 human blood samples with key fatty acid ratios. Nutr J. 2009;8:58. (20) Innis S, Elias SL. Intakes of essential n-6 and n-3 polyunsaturated fatty ac6ids among pregnant Canadian women. Am J Clin Nutr. 2003;77:473-478. (34) Suzuki K, Nakai K, Sugawara T, Nakamura T, Ohba T, Shimada M, Hosokawa T, Okamura K, Sakai T, Kurokawa N, Murata K, Satoh C, Satoh H. Neurobehavioral effects of prenatal exposure to methylmercury and PCBs, and seafood intake: neonatal behavioral assessment scale results of Tohoku study of child development. Environ Res. 2010;110:699-704. (22) Sun Q, Ma J, Campos H, Hankinson SE, Hu FB. Comparison between plasma and erythrocyte fatty acid content as biomarkers of fatty acid intake in US women. Am J Clin Nutr. 2007;86:74-81. (24) Friesen RW, Innis SM. Dietary arachidonic acid to EPA and DHA balance is increased among Canadian pregnant women with low fish intake. J Nutr. 2009;139:2344-2350. (30) 厚生労働省策定．日本人の食事摂取基準［2010年版］．東京:第一出版株式会社，2010:78 (4) Harris WS, Thomas RM. Biological variability of blood omega-3 biomarkers. Clin Biochem. 2010;43:338-340. (8) Harris WS, Sands SA, Windsor SL, Ali HA, Stevens TL, Magalski A, Porter CB, Borkon AM. Omega-3 fatty acids in cardiac biopsies from heart transplantation patients: correlation with erythrocytes and response to supplementation. Circulation. 2004;110:1645-1649. (1) Calder PC, Yaqoob P. Omega-3 polyunsaturated fatty acids and human health outcomes. Biofactors. 2009;35:266-272. (31) 仲井邦彦，中村朋之，村田勝敬，佐藤 洋．東北コーホート調査とばく露評価．日本衛生学雑誌2009;64:749-758 (21) Hodge AM, Simpson JA, Gibson RA, Sinclair AJ, Makrides M, O’Dea K, English DR, Giles GG. Plasma phospholipid fatty acid composition as a biomarker of habitual dietary fat intake in an ethnically diverse cohort. Nutr Metab Cardiovasc Dis. 2007;17:415-426. (9) Metcalf RG, James MJ, Gibson RA, Edwards JR, Stubberfield J, Stuklis R, Roberts-Thomson K, Young GD, Cleland LG. Effects of fish-oil supplementation on myocardial fatty acids in humans. Am J Clin Nutr. 2007;85:1222-1228. (16) Brown AJ, Pang E, Roberts DC. Persistent changes in the fatty acid composition of erythrocyte membranes after moderate intake of n-3 polyunsaturated fatty acids: study design implications. Am J Clin Nutr. 1991;54:668-673. (18) Kuriki K, Nagaya T, Imaeda N, Tokudome Y, Fujiwara N, Sato J, Ikeda M, Maki S, Tokudome S. Discrepancies in dietary intakes and plasma concentrations of fatty acids according to age among Japanese female dietitians. Eur J Clin Nutr. 2002;56:524-531. (28) Cunnane SC, Francescutti V, Brenna JT, Crawford MA. Breast-fed infants achieve a higher rate of brain and whole body docosahexaenoate accumulation than formula-fed infants not consuming dietary docosahexaenoate. Lipids. 2000;35:105-111. (14) Cartwright IJ, Pockley AG, Galloway JH, Greaves M, Preston FE. The effects of dietary omega-3 polyunsaturated fatty acids on erythrocyte membrane phospholipids, erythrocyte deformability and blood viscosity in healthy volunteers. Atherosclerosis. 1985;55:267-281. (5) Katan MB, Deslypere JP, van Birgelen AP, Penders M, Zegwaard M. Kinetics of the incorporation of dietary fatty acids into serum cholesteryl esters, erythrocyte membranes, and adipose tissue: an 18-month controlled study. J Lipid Res. 1997;38:2012-2022. (23) Cao J, Schwichtenberg KA, Hanson NQ, Tsai MY. Incorporation and clearance of omega-3 fatty acids in erythrocyte membranes and plasma phospholipids. Clin Chem. 2006;52:2265-2272. (26) Clandinin MT, Chappell JE, Heim T, Swyer PR, Chance GW. Fatty acid utilization in perinatal de novo synthesis of tissues. Early Hum Dev. 1981;5:355-366. (29) Makrides M, Neumann M, Simmer K, Gibson R, Pater J. Are long-chain polyunsaturated fatty acids essential nutrients in infancy? Lancet. 1995;345:1463-1468. (17) Metherel AH, Armstrong JM, Patterson AC, Stark KD. Assessment of blood measures of n-3 polyunsaturated fatty acids with acute fish oil supplementation and washout in men and women. Prostaglandins Leukot Essent Fatty Acids. 2009;81:23-29. (6) Bersamin A, Luick BR, King IB, Stern JS, Zidenberg-Cherr S. Westernizing diets influence fat intake, red blood cell fatty acid composition, and health in remote Alaskan Native communities in the center for Alaska Native health study. J Am Diet Assoc. 2008;108:266-273. (7) Shannon J, King IB, Lampe JW, Gao DL, Ray RM, Lin MG, Stalsberg H, Thomas DB. Erythrocyte fatty acids and risk of proliferative and nonproliferative fibrocystic disease in women in Shanghai, China. Am J Clin Nutr. 2009;89:265-276. (19) Kobayashi M, Sasaki S, Kawabata T, Hasegawa K, Akabane M, Tsugane S. Single measurement of serum phospholipid fatty acid as a biomarker of specific fatty acid intake in middle-aged Japanese men. Eur J Clin Nutr. 2001;55:643-650. (11) Hirota S, Adachi N, Gomyo T, Kawashima H, Kiso Y, Kawabata T. Low-dose arachidonic acid intake increases erythrocytes and plasma arachidonic acid in young women. Prostaglandins Leukot Essent Fatty Acids. 2010;83:83-88. (12) Fekete K, Marosvölgyi T, Jakobik V, Decsi T. Methods of assessment of n-3 long-chain polyunsaturated fatty acid status in humans: a systematic review. Am J Clin Nutr. 2009;89:2070S-2084S. (25) Martinez M. Tissue levels of polyunsaturated fatty acids during early human development. J Pediatr. 1992;120:S129-S138. (2) Uauy R, Mena P, Rojas C. Essential fatty acids in early life: structural and functional role. Proc Nutr Soc. 2000;59:3-15. (33) Kurokawa N, Nakai K, Suzuki K, Nakamura T, Sakurai K, Shimada M, Ohba T, Satoh C, Kameo S, Okamura K, Satoh H. Relationship between child birth weight and concentration of polychlorinated biphenyls (PCBs) of the mother in Japan. —Tohoku Study of Child Development (TSCD)—. Organohalogen Compounds. 2008;70:2256-2259. |
| References_xml | – reference: (27) Uauy R, Mena P, Wegher B, Nieto S, Salem N Jr. Long chain polyunsaturated fatty acid formation in neonates: effect of gestational age and intrauterine growth. Pediatr Res. 2000;47:127-135. – reference: (10) Sarkadi-Nagy E, Wijendran V, Diau GY, Chao AC, Hsieh AT, Turpeinen A, Lawrence P, Nathanielsz PW, Brenna JT. Formula feeding potentiates docosahexaenoic and arachidonic acid biosynthesis in term and preterm baboon neonates. J Lipid Res. 2004;45:71-80. – reference: (29) Makrides M, Neumann M, Simmer K, Gibson R, Pater J. Are long-chain polyunsaturated fatty acids essential nutrients in infancy? Lancet. 1995;345:1463-1468. – reference: (25) Martinez M. Tissue levels of polyunsaturated fatty acids during early human development. J Pediatr. 1992;120:S129-S138. – reference: (7) Shannon J, King IB, Lampe JW, Gao DL, Ray RM, Lin MG, Stalsberg H, Thomas DB. Erythrocyte fatty acids and risk of proliferative and nonproliferative fibrocystic disease in women in Shanghai, China. Am J Clin Nutr. 2009;89:265-276. – reference: (1) Calder PC, Yaqoob P. Omega-3 polyunsaturated fatty acids and human health outcomes. Biofactors. 2009;35:266-272. – reference: (5) Katan MB, Deslypere JP, van Birgelen AP, Penders M, Zegwaard M. Kinetics of the incorporation of dietary fatty acids into serum cholesteryl esters, erythrocyte membranes, and adipose tissue: an 18-month controlled study. J Lipid Res. 1997;38:2012-2022. – reference: (13) Holub BJ, Wlodek M, Rowe W, Piekarski J. Correlation of omega-3 levels in serum phospholipid from 2053 human blood samples with key fatty acid ratios. Nutr J. 2009;8:58. – reference: (18) Kuriki K, Nagaya T, Imaeda N, Tokudome Y, Fujiwara N, Sato J, Ikeda M, Maki S, Tokudome S. Discrepancies in dietary intakes and plasma concentrations of fatty acids according to age among Japanese female dietitians. Eur J Clin Nutr. 2002;56:524-531. – reference: (34) Suzuki K, Nakai K, Sugawara T, Nakamura T, Ohba T, Shimada M, Hosokawa T, Okamura K, Sakai T, Kurokawa N, Murata K, Satoh C, Satoh H. Neurobehavioral effects of prenatal exposure to methylmercury and PCBs, and seafood intake: neonatal behavioral assessment scale results of Tohoku study of child development. Environ Res. 2010;110:699-704. – reference: (15) Popp-Snijders C, Schouten JA, de Jong AP, van der Veen EA. Effect of dietary cod-liver oil on the lipid composition of human erythrocyte membranes. Scand J Clin Lab Invest. 1984;44:39-46. – reference: (30) 厚生労働省策定．日本人の食事摂取基準［2010年版］．東京:第一出版株式会社，2010:78． – reference: (21) Hodge AM, Simpson JA, Gibson RA, Sinclair AJ, Makrides M, O’Dea K, English DR, Giles GG. Plasma phospholipid fatty acid composition as a biomarker of habitual dietary fat intake in an ethnically diverse cohort. Nutr Metab Cardiovasc Dis. 2007;17:415-426. – reference: (22) Sun Q, Ma J, Campos H, Hankinson SE, Hu FB. Comparison between plasma and erythrocyte fatty acid content as biomarkers of fatty acid intake in US women. Am J Clin Nutr. 2007;86:74-81. – reference: (6) Bersamin A, Luick BR, King IB, Stern JS, Zidenberg-Cherr S. Westernizing diets influence fat intake, red blood cell fatty acid composition, and health in remote Alaskan Native communities in the center for Alaska Native health study. J Am Diet Assoc. 2008;108:266-273. – reference: (19) Kobayashi M, Sasaki S, Kawabata T, Hasegawa K, Akabane M, Tsugane S. Single measurement of serum phospholipid fatty acid as a biomarker of specific fatty acid intake in middle-aged Japanese men. Eur J Clin Nutr. 2001;55:643-650. – reference: (32) Nakajima S, Saijo Y, Kato S, Sasaki S, Uno A, Kanagami N, Hirakawa H, Hori T, Tobiishi K, Todaka T, Nakamura Y, Yanagiya S, Sengoku Y, Iida T, Sata F, Kishi R. Effects of prenatal exposure to polychlorinated biphenyls and dioxins on mental and motor development in Japanese children at 6 months of age. Environ Health Perspect. 2006;114:773-778. – reference: (11) Hirota S, Adachi N, Gomyo T, Kawashima H, Kiso Y, Kawabata T. Low-dose arachidonic acid intake increases erythrocytes and plasma arachidonic acid in young women. Prostaglandins Leukot Essent Fatty Acids. 2010;83:83-88. – reference: (16) Brown AJ, Pang E, Roberts DC. Persistent changes in the fatty acid composition of erythrocyte membranes after moderate intake of n-3 polyunsaturated fatty acids: study design implications. Am J Clin Nutr. 1991;54:668-673. – reference: (23) Cao J, Schwichtenberg KA, Hanson NQ, Tsai MY. Incorporation and clearance of omega-3 fatty acids in erythrocyte membranes and plasma phospholipids. Clin Chem. 2006;52:2265-2272. – reference: (17) Metherel AH, Armstrong JM, Patterson AC, Stark KD. Assessment of blood measures of n-3 polyunsaturated fatty acids with acute fish oil supplementation and washout in men and women. Prostaglandins Leukot Essent Fatty Acids. 2009;81:23-29. – reference: (28) Cunnane SC, Francescutti V, Brenna JT, Crawford MA. Breast-fed infants achieve a higher rate of brain and whole body docosahexaenoate accumulation than formula-fed infants not consuming dietary docosahexaenoate. Lipids. 2000;35:105-111. – reference: (2) Uauy R, Mena P, Rojas C. Essential fatty acids in early life: structural and functional role. Proc Nutr Soc. 2000;59:3-15. – reference: (3) Arab L, Akbar J. Biomarkers and the measurement of fatty acids. Public Health Nutr. 2002;5:865-871. – reference: (8) Harris WS, Sands SA, Windsor SL, Ali HA, Stevens TL, Magalski A, Porter CB, Borkon AM. Omega-3 fatty acids in cardiac biopsies from heart transplantation patients: correlation with erythrocytes and response to supplementation. Circulation. 2004;110:1645-1649. – reference: (4) Harris WS, Thomas RM. Biological variability of blood omega-3 biomarkers. Clin Biochem. 2010;43:338-340. – reference: (24) Friesen RW, Innis SM. Dietary arachidonic acid to EPA and DHA balance is increased among Canadian pregnant women with low fish intake. J Nutr. 2009;139:2344-2350. – reference: (26) Clandinin MT, Chappell JE, Heim T, Swyer PR, Chance GW. Fatty acid utilization in perinatal de novo synthesis of tissues. Early Hum Dev. 1981;5:355-366. – reference: (33) Kurokawa N, Nakai K, Suzuki K, Nakamura T, Sakurai K, Shimada M, Ohba T, Satoh C, Kameo S, Okamura K, Satoh H. Relationship between child birth weight and concentration of polychlorinated biphenyls (PCBs) of the mother in Japan. —Tohoku Study of Child Development (TSCD)—. Organohalogen Compounds. 2008;70:2256-2259. – reference: (9) Metcalf RG, James MJ, Gibson RA, Edwards JR, Stubberfield J, Stuklis R, Roberts-Thomson K, Young GD, Cleland LG. Effects of fish-oil supplementation on myocardial fatty acids in humans. Am J Clin Nutr. 2007;85:1222-1228. – reference: (14) Cartwright IJ, Pockley AG, Galloway JH, Greaves M, Preston FE. The effects of dietary omega-3 polyunsaturated fatty acids on erythrocyte membrane phospholipids, erythrocyte deformability and blood viscosity in healthy volunteers. Atherosclerosis. 1985;55:267-281. – reference: (12) Fekete K, Marosvölgyi T, Jakobik V, Decsi T. Methods of assessment of n-3 long-chain polyunsaturated fatty acid status in humans: a systematic review. Am J Clin Nutr. 2009;89:2070S-2084S. – reference: (31) 仲井邦彦，中村朋之，村田勝敬，佐藤 洋．東北コーホート調査とばく露評価．日本衛生学雑誌2009;64:749-758． – reference: (20) Innis S, Elias SL. Intakes of essential n-6 and n-3 polyunsaturated fatty ac6ids among pregnant Canadian women. Am J Clin Nutr. 2003;77:473-478. |
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| Title | 生物学的モニタリングのための血漿および赤血球膜リン脂質中長鎖多価不飽和脂肪酸の比較 |
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