もの忘れを主訴に外来受診した患者の認知機能に関する研究

MCIがADの前段階として注目され、ADへの移行に関する研究が進められている。本研究では、コンピュータ化された認知機能測定ツールであるCogHealthを用いて45名のMCI例の認知機能を測定し、CogHealthの測定結果を海馬血流量およびMMSEの得点と比較検討した。また、対象者のCogHealthによる認知機能測定項目の値を健常群の値と比較検討した。その結果、健常群との比較で、MMSE低得点群においてCogHealthの測定項目である作動記憶の反応の正確さとエピソード記憶の反応速度の値が有意に低下（p<0.01）していたことから、作動記憶の正確さの低下が主たるものであることが示され...

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Published in杏林医学会雑誌 Vol. 45; no. 2; pp. 51 - 65
Main Author 大澤, 亜貴子
Format Journal Article
LanguageJapanese
Published 杏林医学会 2014
Online AccessGet full text
ISSN0368-5829
1349-886X
DOI10.11434/kyorinmed.45.51

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Abstract MCIがADの前段階として注目され、ADへの移行に関する研究が進められている。本研究では、コンピュータ化された認知機能測定ツールであるCogHealthを用いて45名のMCI例の認知機能を測定し、CogHealthの測定結果を海馬血流量およびMMSEの得点と比較検討した。また、対象者のCogHealthによる認知機能測定項目の値を健常群の値と比較検討した。その結果、健常群との比較で、MMSE低得点群においてCogHealthの測定項目である作動記憶の反応の正確さとエピソード記憶の反応速度の値が有意に低下（p<0.01）していたことから、作動記憶の正確さの低下が主たるものであることが示され、また、神経伝達に時間がかかっていることが示唆された。そして、MMSE高得点群においても、CogHealthの測定項目である作動記憶の反応の正確さとエピソード記憶の反応速度の値が健常群に比べて有意に低下（p<0.01）していたことから、CogHealthはより早期の認知機能低下を発見できると思われた。
AbstractList 「要旨」MCIがADの前段階として注目され, ADへの移行に関する研究が進められている. 本研究では, コンピュータ化された認知機能測定ツールであるCogHealthを用いて45名のMCI例の認知機能を測定し, CogHealthの測定結果を海馬血流量およびMMSEの得点と比較検討した. また, 対象者のCogHealthによる認知機能測定項目の値を健常群の値と比較検討した. その結果, 健常群との比較で, MMSE低得点群においてCogHealthの測定項目である作動記憶の反応の正確さとエピソード記憶の反応速度の値が有意に低下(p<0.01)していたことから, 作動記憶の正確さの低下が主たるものであることが示され, また, 神経伝達に時間がかかっていることが示唆された. そして, MMSE高得点群においても, CogHealthの測定項目である作動記憶の反応の正確さとエピソード記憶の反応速度の値が健常群に比べて有意に低下(p<0.01)していたことから, CogHealthはより早期の認知機能低下を発見できると思われた.
MCIがADの前段階として注目され、ADへの移行に関する研究が進められている。本研究では、コンピュータ化された認知機能測定ツールであるCogHealthを用いて45名のMCI例の認知機能を測定し、CogHealthの測定結果を海馬血流量およびMMSEの得点と比較検討した。また、対象者のCogHealthによる認知機能測定項目の値を健常群の値と比較検討した。その結果、健常群との比較で、MMSE低得点群においてCogHealthの測定項目である作動記憶の反応の正確さとエピソード記憶の反応速度の値が有意に低下（p<0.01）していたことから、作動記憶の正確さの低下が主たるものであることが示され、また、神経伝達に時間がかかっていることが示唆された。そして、MMSE高得点群においても、CogHealthの測定項目である作動記憶の反応の正確さとエピソード記憶の反応速度の値が健常群に比べて有意に低下（p<0.01）していたことから、CogHealthはより早期の認知機能低下を発見できると思われた。
Author 大澤, 亜貴子
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– reference: 54）Tom Kitwood. Dementia Reconsidered the person comes first. 高橋誠一訳.　認知症のパーソンドケア. 第5刷.　東京，筒井書房，176-179，2011
– reference: 19）川畑信也，後藤千春，彦坂しのぶ：認知機能障害の全般的評価に関する神経心理学的検査―Mini-Mental State Examination（MMSE）からみた検討―.　日本臨牀　61（9）：192-197，2003
– reference: 30）山本泰司：軽度認知障害（MCI）に関する最近の話題．精神経雑誌　113（6）：584-592，2011
– reference: 48）Troster AI; Neuropsychological characteristics of dementia with Lewy bodies and Parkinson’s disease with dementia: Differentiation, early detection, and implications for “mild cognitive impairment” and biomarkers. Neuropsychol Rev 18（1）: 103-119, 2008
– reference: 13）Borson S, Scanlan JM, Lessing M, DeMers S.: Comorbidity in aging and dementia: scales differ, and the difference matters. Am J Geriatr Psychiatry. 18（11）: 999-1006, 2010
– reference: 35）Uchida Y, Minoshima S, Okada S, Kawata T, Ito H.: Diagnosis of dementia using perfusion SPECT imaging at the patient’s initial visit to a cognitive disorder clinic. Clin Nucl Med. 31（12）: 764-773, 2006
– reference: 46）Nebes RD, Brady CB: Focused and divided attention in Alzheimer’s disease. Cortex 25（2）: 305-315, 1989
– reference: 11）Jennifer L. Shaffer, Jeffrey R. Petrella, Forrest C. Sheldon, Kingshuk Roy Choudhury, Vince D. Calhoun, R. Edward Coleman: Predicting Cognitive Decline in Subjects at Risk for Alzheimer Disease by Using Combined Cerebrospinal Fluid, MR Imaging, and PET Biomarkers. Radiology 266（2）: 583-591, 2013
– reference: 7）Petersen RC.: Mild cognitive impairment as a diagnostic entity. J Intern Med. 256（3）: 183-194, 2004
– reference: 22）Collie, A., Maruff, P., Makdissi, M., McStephen, M., Darby, D.G.: CogSport: Reliability and correlation with conventional cognitive tests used in post-concussion medical examinations. Clinical Journal of Sports Medicine. 13: 28-32, 2004
– reference: 49）Braak H, Braak E: Staging of Alzheimer’s disease-related neurofibrillary changes. Neurobiol Aging 16（3）: 271-284, 1995
– reference: 33）Zaknun JJ, Leblhuber F, Schücktanz H.: Value of cerebral blood flow quantification in the diagnosis of dementia. Nucl Med Commun. 29（3）: 260-269,　2008
– reference: 27）Silbert, B., Maruff, P., Evered, L., Scott, D., Kalpokas, M., Martin, K.J., Lewis, M., Myles, P.: Detection of cognitive decline after coronary surgery: A comparison of computerized and conventional tests. British Journal of Anaesthesia 92: 814-820, 2004
– reference: 29）Winblad B, Palmer K, Kivipelto M, Jelic V, Fratiglioni L, Wahlund LO, Nordberg A, Bäckman L, Albert M, Almkvist O, Arai H, Basun H, Blennow K, de Leon M, DeCarli C, Erkinjuntti T, Giacobini E, Graff C, Hardy J, Jack C, Jorm A, Ritchie K, van Duijn C, Visser P, Petersen RC.：Mild cognitive impairment-beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. J Intern Med. 256（3）: 240-246, 2004
– reference: 43）Tombaugh TN, Mclntyre NJ: The Mini-Mental State Examination: a comprehensive review. J Am Geriatr Soc 40: 922-935, 1992
– reference: 38）Nestor PJ, Fryer TD, Hodges JR: Declarative memory impairments in Alzheimer’s disease and semantic dementia. Neuroimage 30（3）: 1010-1020, 2006
– reference: 8）朝田 隆，木田 次朗：MCIの原因となる疾患の診断と対応. 老年精神医学雑誌20（1）: 41-46，2009.
– reference: 21）P.Maruff, A. Colie, D. Darby, J. Weaver-Cargin, C. Masters, Jon Currie: Subtle Memory Decline over 12 Months in Mild Cognitive Impairment. Dement Geriatr Cogn Disord. 18: 342-348, 2004
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Snippet MCIがADの前段階として注目され、ADへの移行に関する研究が進められている。本研究では、コンピュータ化された認知機能測定ツールであるCogHealthを用いて45名のMCI例の認知...
「要旨」MCIがADの前段階として注目され, ADへの移行に関する研究が進められている. 本研究では, コンピュータ化された認知機能測定ツールであるCogHealthを用いて45名のMCI...
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Title もの忘れを主訴に外来受診した患者の認知機能に関する研究
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