非ステロイド性抗炎症薬の抗血小板作用に関するPK/PD解析
「緒言」アスピリンは低用量で用いると血小板凝集抑制作用により血栓・塞栓性疾患の予防効果を示すことから, 主に心筋梗塞や脳梗塞などの二次予防を目的として汎用されている. しかし, 低用量アスピリンは優れた有効性を示す一方で, 消化管出血などの副作用を引き起こす可能性が知られており, リスクとベネフィットを十分に考慮したうえで投与する必要がある. 低用量アスピリンの抗血小板作用は, 血小板のシクロオキシゲナーゼ(cyclooxygenase:COX)-1を阻害することによって発現するが, アスピリン以外の非ステロイド性抗炎症薬(nonsteroidal anti-inflammatory drug...
Saved in:
| Published in | 医療薬学 Vol. 41; no. 6; pp. 404 - 414 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人日本医療薬学会
10.06.2015
日本医療薬学会 |
| Online Access | Get full text |
| ISSN | 1346-342X 1882-1499 |
| DOI | 10.5649/jjphcs.41.404 |
Cover
| Abstract | 「緒言」アスピリンは低用量で用いると血小板凝集抑制作用により血栓・塞栓性疾患の予防効果を示すことから, 主に心筋梗塞や脳梗塞などの二次予防を目的として汎用されている. しかし, 低用量アスピリンは優れた有効性を示す一方で, 消化管出血などの副作用を引き起こす可能性が知られており, リスクとベネフィットを十分に考慮したうえで投与する必要がある. 低用量アスピリンの抗血小板作用は, 血小板のシクロオキシゲナーゼ(cyclooxygenase:COX)-1を阻害することによって発現するが, アスピリン以外の非ステロイド性抗炎症薬(nonsteroidal anti-inflammatory drugs:NSAIDs)もCOX-1を阻害することから, 低用量アスピリンと同様に抗血小板作用があると考えられる. ただし, アスピリンは血小板のCOX-1の内部にある530位のセリン残基をアセチル化して不可逆的な作用を示すのに対し, アスピリン以外のNSAIDsは主にCOX-1の120位のアルギニン残基と塩橋を形成することによって可逆的な作用を示すという違いがあるため, 低用量アスピリンとは異なり, NSAIDsの抗血小板作用は一過性のものとなると予想される. |
|---|---|
| AbstractList | 「緒言」アスピリンは低用量で用いると血小板凝集抑制作用により血栓・塞栓性疾患の予防効果を示すことから, 主に心筋梗塞や脳梗塞などの二次予防を目的として汎用されている. しかし, 低用量アスピリンは優れた有効性を示す一方で, 消化管出血などの副作用を引き起こす可能性が知られており, リスクとベネフィットを十分に考慮したうえで投与する必要がある. 低用量アスピリンの抗血小板作用は, 血小板のシクロオキシゲナーゼ(cyclooxygenase:COX)-1を阻害することによって発現するが, アスピリン以外の非ステロイド性抗炎症薬(nonsteroidal anti-inflammatory drugs:NSAIDs)もCOX-1を阻害することから, 低用量アスピリンと同様に抗血小板作用があると考えられる. ただし, アスピリンは血小板のCOX-1の内部にある530位のセリン残基をアセチル化して不可逆的な作用を示すのに対し, アスピリン以外のNSAIDsは主にCOX-1の120位のアルギニン残基と塩橋を形成することによって可逆的な作用を示すという違いがあるため, 低用量アスピリンとは異なり, NSAIDsの抗血小板作用は一過性のものとなると予想される. |
| Author | 山本, 康次郎 下村, 斉 荒井, 碧 赤木, 祐貴 青山, 隆夫 |
| Author_xml | – sequence: 1 fullname: 赤木, 祐貴 organization: 独立行政法人国立病院機構横浜医療センター薬剤部 – sequence: 1 fullname: 下村, 斉 organization: 東京理科大学薬学部 – sequence: 1 fullname: 青山, 隆夫 organization: 東京理科大学薬学部 – sequence: 1 fullname: 荒井, 碧 organization: 東京理科大学薬学部 – sequence: 1 fullname: 山本, 康次郎 organization: 群馬大学医学部附属病院薬剤部 |
| BookMark | eNo1kElLA0EQhRtRcD36MyZ2ddcsfVPcMWIOCt6ansmMzpBMwowevJkEFBXUgxgEFVxAwQWvHsQf05rEf-HE5fJePYr6HtQg6Y0rsU_IKNCcaaEYi6LqupfmEHJIsYcMgOMwA1CI3mzmaBkc2Wo_GUnT0KWUA1hgigGy-HVxqeuvurGjG0-6fqsbe63tu9Z-s10_bDd3O6ePuvacxc7V9ufLUevi_ePtvH1yr2sPX6fXunam6weFhbHCVOfupnV5PEz6AlVK_ZE_HyIrM9PLk3NGfml2fnIib0QcGDUcCqZiNPCY7zBBgTOFtuvYwhYBt1XATe4rBN-BYhB4AUPXQhCeC7bp2gEyPkRmf7llvxh6qlSJS2Hsy6iymcRZryy6ZnVdJWXJsiZJKQK1uiYp_gggQ0vYtEsa_yVF6YZa82U1Ccsq2ZIq2Qi9Uob8eatEkFZXuuf_Ky9rkJHi374Mitk |
| ContentType | Journal Article |
| Copyright | 2015 日本医療薬学会 |
| Copyright_xml | – notice: 2015 日本医療薬学会 |
| CorporateAuthor | 群馬大学医学部附属病院薬剤部 独立行政法人国立病院機構横浜医療センター薬剤部 東京理科大学薬学部 |
| CorporateAuthor_xml | – name: 東京理科大学薬学部 – name: 群馬大学医学部附属病院薬剤部 – name: 独立行政法人国立病院機構横浜医療センター薬剤部 |
| DOI | 10.5649/jjphcs.41.404 |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1882-1499 |
| EndPage | 414 |
| ExternalDocumentID | db5pharm_2015_004106_004_0404_04142469702 article_jjphcs_41_6_41_404_article_char_ja |
| GroupedDBID | .LE 5GY ABJNI ALMA_UNASSIGNED_HOLDINGS KQ8 MOJWN RJT |
| ID | FETCH-LOGICAL-j3120-8015a20fc2e8290132a47b87979f37af353ea41e81dffcf24b6419cb175b7f423 |
| ISSN | 1346-342X |
| IngestDate | Thu Jul 10 16:12:01 EDT 2025 Wed Sep 03 06:15:56 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 6 |
| Language | Japanese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-j3120-8015a20fc2e8290132a47b87979f37af353ea41e81dffcf24b6419cb175b7f423 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/jjphcs/41/6/41_404/_article/-char/ja |
| PageCount | 11 |
| ParticipantIDs | medicalonline_journals_db5pharm_2015_004106_004_0404_04142469702 jstage_primary_article_jjphcs_41_6_41_404_article_char_ja |
| PublicationCentury | 2000 |
| PublicationDate | 20150610 |
| PublicationDateYYYYMMDD | 2015-06-10 |
| PublicationDate_xml | – month: 06 year: 2015 text: 20150610 day: 10 |
| PublicationDecade | 2010 |
| PublicationTitle | 医療薬学 |
| PublicationTitleAlternate | 医療薬学 |
| PublicationYear | 2015 |
| Publisher | 一般社団法人日本医療薬学会 日本医療薬学会 |
| Publisher_xml | – name: 一般社団法人日本医療薬学会 – name: 日本医療薬学会 |
| References | 20）浅田玲子, 散乱光を用いた血小板凝集能に影響を及ぼす測定条件の検討, 医学検査, 2008, 57, 1223-1230. 16）原田耕吉, 片山 敏, 代田 寛, 千葉健一, 堀添達央, 安部禎寿, サチグレル（E5510）の各種動物の血小板におけるin vitroでの血小板凝集阻害作用, 薬理と治療, 1996, 24Suppl 2, S289-S298. 18) Callan OH, So OY, Swinney DC, The kinetic factors that determine the affinity and selectivity for slow binding inhibition of human prostaglandin H synthase 1 and 2 by indomethacin and flurbiprofen, J Biol Chem, 1996, 271, 3548-3554. 15）並木和子, 茶の機能〔7〕茶の血小板凝集抑制作用, 食品と容器, 2005, 46, 320-327. 35) 抗血栓薬服用者に対する消化器内視鏡診療ガイドライン, 日本消化器内視鏡学会雑誌, 2012, 54, 2073-2102. 37) Engel C, Lund B, Kristensen SS, Axel C, Nielsen JB, Indomethacin as analgesic after hysterectomy, Acta Anaesthesiol Scand, 1989, 33, 498-501. 29) Ouellet M, Riendeau D, Percival MD, A high level of cyclooxygenase-2 inhibitor selectivity is associated with a reduced interference of platelet cyclooxygenase-1 inactivation by aspirin, Proc Natl Acad Sci USA, 2001, 98, 14583-14588. 26) Cronberg S, Wallmark E, Söderberg I, Effect on platelet aggregation of oral administration of 10 non–steroidal analgesics to humans, Scand J Haematol, 1984, 33, 155-159. 24) Patrignani P, Filabozzi P, Patrono C, Selective cumulative inhibition of platelet thromboxane production by low-dose aspirin in healthy subjects, J Clin Invest, 1982, 69, 1366-1372. 28) Villanueva M, Heckenberger R, Strobach H, Palmér M, Schrör K, Equipotent inhibition by R(–)-, S(+)- and racemic ibuprofen of human polymorphonuclear cell function in vitro, Br J Clin Pharmacol, 1993, 35, 235-242. 25) Feldman M, Shewmake K, Cryer B, Time course inhibition of gastric and platelet COX activity by acetylsalicylic acid in humans, Am J Physiol Gastrointest Liver Physiol, 2000, 279, G1113-G1120. 10) Ding G, Liu Y, Sun J, Takeuchi Y, Toda T, Hayakawa T, Fukushima S, Kishimoto S, Lin W, Inotsume N, Effect of absorption rate on pharmacokinetics of ibuprofen in relation to chiral inversion in humans, J Pharm Pharmacol, 2007, 59, 1509-1513. 1) Yasue H, Ogawa H, Tanaka H, Miyazaki S, Hattori R, Saito M, Ishikawa K, Masuda Y, Yamaguchi T, Motomiya T, Tamura Y, Effects of aspirin and trapidil on cardiovascular events after acute myocardial infarction. Japanese Antiplatelets Myocardial Infarction Study (JAMIS) Investigators, Am J Cardiol, 1999, 83, 1308-1313. 5) Smith WL, Marnett LJ, Prostaglandin endoperoxide synthase: structure and catalysis, Biochim Biophys Acta, 1991, 1083, 1-17. 12）栗山欣彌, 藤田大祐, 木谷輝夫, RAK-591（etodolac）の臨床第一相試験, 臨床医薬, 1987, 3, 419-446. 30) Tabuchi A, Taniguchi R, Takahashi K, Kondo H, Kawato M, Morimoto T, Kimura T, Kita T, Horiuchi H, Action of aspirin on whole blood-aggregation evaluated by the screen filtration pressure method, Circ J, 2008, 72, 420-426. 33) Hernández-Diaz S, Rodríguez LA, Association between nonsteroidal anti-inflammatory drugs and upper gastrointestinal tract bleeding/perforation: an overview of epidemiologic studies published in the 1990s, Arch Intern Med, 2000, 160, 2093-2099. 19) Born GV, Aggregation of blood platelets by adenosine diphosphate and its reversal, Nature, 1962, 194, 927-929. 31) Kawai S, Nishida S, Kato M, Furumaya Y, Okamoto R, Koshino T, Mizushima Y, Comparison of cyclooxygenase-1 and -2 inhibitory activities of various nonsteroidal anti-inflammatory drugs using human platelets and synovial cells, Eur J Pharmacol, 1998, 347, 87-94. 34) Huang JQ, Sridhar S, Hunt RH, Role of Helicobacter pylori infection and non-steroidal anti-inflammatory drugs in peptic-ulcer disease: a meta-analysis, Lancet, 2002, 359, 14-22. 36) Fransen M, Anderson C, Douglas J, MacMahon S, Neal B, Norton R, Woodward M, Cameron ID, Crawford R, Lo SK, Tregonning G, Windolf M, HIPAID Collaborative Group, Safety and efficacy of routine postoperative ibuprofen for pain and disability related to ectopic bone formation after hip replacement surgery (HIPAID): randomised controlled trial, BMJ, 2006, 333, 519-523. 6) Picot D, Loll PJ, Garavito RM, The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1, Nature, 1994, 367, 243-249. 14）小内 亨, サプリメントの適正使用とその指導, 薬局, 2004, 55, 1831-1838. 23) Riendeau D, Salem M, Styhler A, Ouellet M, Mancini JA, Li CS, Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2, Bioorg Med Chem Lett, 2004, 14, 1201-1203. 4) Sakamoto C, Sugano K, Ota S, Sakaki N, Takahashi S, Yoshida Y, Tsukui T, Osawa H, Sakurai Y, Yoshino J, Mizokami Y, Mine T, Arakawa T, Kuwayama H, Saigenji K, Yakabi K, Chiba T, Shimosegawa T, Sheehan JE, Perez-Gutthann S, Yamaguchi T, Kaufman DW, Sato T, Kubota K, Terano A, Case-control study on the association of upper gastrointestinal bleeding and nonsteroidal anti-inflammatory drugs in Japan, Eur J Clin Phamacol, 2006, 62, 765-772. 13) Oliary J, Tod M, Nicolas P, Petitjean O, Caille G, Pharmacokinetics of ibuprofen enantiomer after single and repeated doses in man, Biopharm Drug Dispos, 1992, 13, 337-344. 21) Imiya T, Matsuo T, A New parameter for evaluating platelet aggregation in patients with chronic cerenral infarction, Rinsho byori, 1993, 41, 923-929. 8）赤木祐貴, 柴田健太, 嶋田修治, 谷中昭典, 樋上賀一, 土谷隆紀, 久保田芳郎, 青山隆夫, アスピリンの抗血小板作用に及ぼすロキソプロフェンナトリウムの影響とその回避方法, 医療薬学, 2011, 37, 69-77. 27) De la Cruz JP, Reyes JJ, Ruiz-Moreno MI, Lopez-Villodres JA, Jebrouni N, Gonzalez-Correa JA, Differences in the in vitro antiplatelet effect of dexibuprofen, ibuprofen, and flurbiprofen in human blood, Anesth Analg, 2010, 111, 1341-1346. 2) Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group, Lancet, 1988, 2, 349-360. 7) Catella-Lawson F, Reilly MP, Kapoor SC, Cucchiara AJ, DeMarco S, Tournier B, Vyas SN, Fitzgerald GA, Cyclooxygenase inhibitors and the antiplatelet effects of aspirin, N Engl J Med, 2001, 345, 1809-1817. 32) Lanas A, García-Rodríguez LA, Arroyo MT, Gomollón F, Feu F, González-Pérez A, Zapata E, Bástida G, Rodrigo L, Santolaria S, Güell M, de Argila CM, Quintero E, Borda F, Piqué JM; Asociación Española de Gastroenterología, Risk of upper gastrointestinal ulcer bleeding associated with selective cyclo-oxygenase-2 inhibitors, traditional non-aspirin non-steroidal anti-inflammatory drugs, aspirin and combinations, Gut, 2006, 55, 1731-1738. 3) The Canadian Cooperative Study Group: A randomized trial of aspirin and sulfinpyrazone in threatened stroke, N Engl J Med, 1978, 299, 53-59. 11) Takasaki W, Tanaka Y, Application of antibody-mediated extraction for the stereoselective determination of the active metabolite of loxoprofen in human and rat plasma, Chirality, 1992, 4, 308-315. 17）赤木祐貴, 柴田健太, 仁尾祐太, 谷中昭典, 樋上賀一, 嶋田修治, 青山隆夫, アスピリンの抗血小板作用に及ぼす非ステロイド性抗炎症薬の影響に関する研究－ヒト血液添加実験系を用いた検討－, 医療薬学, 2010, 36, 382-391. 22) Evans AM, Nation RL, Sansom LN, Bochner F, Somogyi AA, Effect of racemic ibuprofen dose on the magnitude and duration of platelet cyclo-oxygenase inhibition: relationship between inhibition of thromboxane production and the plasma unbound concentration of S(+)-ibuprofen, Br J Clin Pharmacol, 1991, 31, 131-138. 9) Renda G, Tacconelli S, Capone ML, Sacchetta D, Santarelli F, Sciulli MG, Zimarino M, Grana M, D'Amelio E, Zurro M, Price TS, Patrono C, De Caterina R, Patrignani P, Celecoxib, ibuprofen, and the antiplatelet effect of aspirin in patients with osteoarthritis and ischemic heart disease, Clin Pharmacol Ther, 2006, 80, 264-274. |
| References_xml | – reference: 4) Sakamoto C, Sugano K, Ota S, Sakaki N, Takahashi S, Yoshida Y, Tsukui T, Osawa H, Sakurai Y, Yoshino J, Mizokami Y, Mine T, Arakawa T, Kuwayama H, Saigenji K, Yakabi K, Chiba T, Shimosegawa T, Sheehan JE, Perez-Gutthann S, Yamaguchi T, Kaufman DW, Sato T, Kubota K, Terano A, Case-control study on the association of upper gastrointestinal bleeding and nonsteroidal anti-inflammatory drugs in Japan, Eur J Clin Phamacol, 2006, 62, 765-772. – reference: 13) Oliary J, Tod M, Nicolas P, Petitjean O, Caille G, Pharmacokinetics of ibuprofen enantiomer after single and repeated doses in man, Biopharm Drug Dispos, 1992, 13, 337-344. – reference: 21) Imiya T, Matsuo T, A New parameter for evaluating platelet aggregation in patients with chronic cerenral infarction, Rinsho byori, 1993, 41, 923-929. – reference: 27) De la Cruz JP, Reyes JJ, Ruiz-Moreno MI, Lopez-Villodres JA, Jebrouni N, Gonzalez-Correa JA, Differences in the in vitro antiplatelet effect of dexibuprofen, ibuprofen, and flurbiprofen in human blood, Anesth Analg, 2010, 111, 1341-1346. – reference: 31) Kawai S, Nishida S, Kato M, Furumaya Y, Okamoto R, Koshino T, Mizushima Y, Comparison of cyclooxygenase-1 and -2 inhibitory activities of various nonsteroidal anti-inflammatory drugs using human platelets and synovial cells, Eur J Pharmacol, 1998, 347, 87-94. – reference: 26) Cronberg S, Wallmark E, Söderberg I, Effect on platelet aggregation of oral administration of 10 non–steroidal analgesics to humans, Scand J Haematol, 1984, 33, 155-159. – reference: 10) Ding G, Liu Y, Sun J, Takeuchi Y, Toda T, Hayakawa T, Fukushima S, Kishimoto S, Lin W, Inotsume N, Effect of absorption rate on pharmacokinetics of ibuprofen in relation to chiral inversion in humans, J Pharm Pharmacol, 2007, 59, 1509-1513. – reference: 7) Catella-Lawson F, Reilly MP, Kapoor SC, Cucchiara AJ, DeMarco S, Tournier B, Vyas SN, Fitzgerald GA, Cyclooxygenase inhibitors and the antiplatelet effects of aspirin, N Engl J Med, 2001, 345, 1809-1817. – reference: 35) 抗血栓薬服用者に対する消化器内視鏡診療ガイドライン, 日本消化器内視鏡学会雑誌, 2012, 54, 2073-2102. – reference: 8）赤木祐貴, 柴田健太, 嶋田修治, 谷中昭典, 樋上賀一, 土谷隆紀, 久保田芳郎, 青山隆夫, アスピリンの抗血小板作用に及ぼすロキソプロフェンナトリウムの影響とその回避方法, 医療薬学, 2011, 37, 69-77. – reference: 24) Patrignani P, Filabozzi P, Patrono C, Selective cumulative inhibition of platelet thromboxane production by low-dose aspirin in healthy subjects, J Clin Invest, 1982, 69, 1366-1372. – reference: 36) Fransen M, Anderson C, Douglas J, MacMahon S, Neal B, Norton R, Woodward M, Cameron ID, Crawford R, Lo SK, Tregonning G, Windolf M, HIPAID Collaborative Group, Safety and efficacy of routine postoperative ibuprofen for pain and disability related to ectopic bone formation after hip replacement surgery (HIPAID): randomised controlled trial, BMJ, 2006, 333, 519-523. – reference: 1) Yasue H, Ogawa H, Tanaka H, Miyazaki S, Hattori R, Saito M, Ishikawa K, Masuda Y, Yamaguchi T, Motomiya T, Tamura Y, Effects of aspirin and trapidil on cardiovascular events after acute myocardial infarction. Japanese Antiplatelets Myocardial Infarction Study (JAMIS) Investigators, Am J Cardiol, 1999, 83, 1308-1313. – reference: 15）並木和子, 茶の機能〔7〕茶の血小板凝集抑制作用, 食品と容器, 2005, 46, 320-327. – reference: 37) Engel C, Lund B, Kristensen SS, Axel C, Nielsen JB, Indomethacin as analgesic after hysterectomy, Acta Anaesthesiol Scand, 1989, 33, 498-501. – reference: 25) Feldman M, Shewmake K, Cryer B, Time course inhibition of gastric and platelet COX activity by acetylsalicylic acid in humans, Am J Physiol Gastrointest Liver Physiol, 2000, 279, G1113-G1120. – reference: 29) Ouellet M, Riendeau D, Percival MD, A high level of cyclooxygenase-2 inhibitor selectivity is associated with a reduced interference of platelet cyclooxygenase-1 inactivation by aspirin, Proc Natl Acad Sci USA, 2001, 98, 14583-14588. – reference: 32) Lanas A, García-Rodríguez LA, Arroyo MT, Gomollón F, Feu F, González-Pérez A, Zapata E, Bástida G, Rodrigo L, Santolaria S, Güell M, de Argila CM, Quintero E, Borda F, Piqué JM; Asociación Española de Gastroenterología, Risk of upper gastrointestinal ulcer bleeding associated with selective cyclo-oxygenase-2 inhibitors, traditional non-aspirin non-steroidal anti-inflammatory drugs, aspirin and combinations, Gut, 2006, 55, 1731-1738. – reference: 6) Picot D, Loll PJ, Garavito RM, The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1, Nature, 1994, 367, 243-249. – reference: 20）浅田玲子, 散乱光を用いた血小板凝集能に影響を及ぼす測定条件の検討, 医学検査, 2008, 57, 1223-1230. – reference: 22) Evans AM, Nation RL, Sansom LN, Bochner F, Somogyi AA, Effect of racemic ibuprofen dose on the magnitude and duration of platelet cyclo-oxygenase inhibition: relationship between inhibition of thromboxane production and the plasma unbound concentration of S(+)-ibuprofen, Br J Clin Pharmacol, 1991, 31, 131-138. – reference: 23) Riendeau D, Salem M, Styhler A, Ouellet M, Mancini JA, Li CS, Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2, Bioorg Med Chem Lett, 2004, 14, 1201-1203. – reference: 16）原田耕吉, 片山 敏, 代田 寛, 千葉健一, 堀添達央, 安部禎寿, サチグレル（E5510）の各種動物の血小板におけるin vitroでの血小板凝集阻害作用, 薬理と治療, 1996, 24Suppl 2, S289-S298. – reference: 9) Renda G, Tacconelli S, Capone ML, Sacchetta D, Santarelli F, Sciulli MG, Zimarino M, Grana M, D'Amelio E, Zurro M, Price TS, Patrono C, De Caterina R, Patrignani P, Celecoxib, ibuprofen, and the antiplatelet effect of aspirin in patients with osteoarthritis and ischemic heart disease, Clin Pharmacol Ther, 2006, 80, 264-274. – reference: 3) The Canadian Cooperative Study Group: A randomized trial of aspirin and sulfinpyrazone in threatened stroke, N Engl J Med, 1978, 299, 53-59. – reference: 11) Takasaki W, Tanaka Y, Application of antibody-mediated extraction for the stereoselective determination of the active metabolite of loxoprofen in human and rat plasma, Chirality, 1992, 4, 308-315. – reference: 19) Born GV, Aggregation of blood platelets by adenosine diphosphate and its reversal, Nature, 1962, 194, 927-929. – reference: 18) Callan OH, So OY, Swinney DC, The kinetic factors that determine the affinity and selectivity for slow binding inhibition of human prostaglandin H synthase 1 and 2 by indomethacin and flurbiprofen, J Biol Chem, 1996, 271, 3548-3554. – reference: 12）栗山欣彌, 藤田大祐, 木谷輝夫, RAK-591（etodolac）の臨床第一相試験, 臨床医薬, 1987, 3, 419-446. – reference: 17）赤木祐貴, 柴田健太, 仁尾祐太, 谷中昭典, 樋上賀一, 嶋田修治, 青山隆夫, アスピリンの抗血小板作用に及ぼす非ステロイド性抗炎症薬の影響に関する研究－ヒト血液添加実験系を用いた検討－, 医療薬学, 2010, 36, 382-391. – reference: 2) Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group, Lancet, 1988, 2, 349-360. – reference: 28) Villanueva M, Heckenberger R, Strobach H, Palmér M, Schrör K, Equipotent inhibition by R(–)-, S(+)- and racemic ibuprofen of human polymorphonuclear cell function in vitro, Br J Clin Pharmacol, 1993, 35, 235-242. – reference: 14）小内 亨, サプリメントの適正使用とその指導, 薬局, 2004, 55, 1831-1838. – reference: 30) Tabuchi A, Taniguchi R, Takahashi K, Kondo H, Kawato M, Morimoto T, Kimura T, Kita T, Horiuchi H, Action of aspirin on whole blood-aggregation evaluated by the screen filtration pressure method, Circ J, 2008, 72, 420-426. – reference: 34) Huang JQ, Sridhar S, Hunt RH, Role of Helicobacter pylori infection and non-steroidal anti-inflammatory drugs in peptic-ulcer disease: a meta-analysis, Lancet, 2002, 359, 14-22. – reference: 33) Hernández-Diaz S, Rodríguez LA, Association between nonsteroidal anti-inflammatory drugs and upper gastrointestinal tract bleeding/perforation: an overview of epidemiologic studies published in the 1990s, Arch Intern Med, 2000, 160, 2093-2099. – reference: 5) Smith WL, Marnett LJ, Prostaglandin endoperoxide synthase: structure and catalysis, Biochim Biophys Acta, 1991, 1083, 1-17. |
| SSID | ssib003116159 ssib002484604 ssib000871962 ssib060196744 ssj0069027 ssib005902156 ssib023157658 |
| Score | 2.02477 |
| Snippet | 「緒言」アスピリンは低用量で用いると血小板凝集抑制作用により血栓・塞栓性疾患の予防効果を示すことから, 主に心筋梗塞や脳梗塞などの二次予防を目的として汎... |
| SourceID | medicalonline jstage |
| SourceType | Publisher |
| StartPage | 404 |
| Title | 非ステロイド性抗炎症薬の抗血小板作用に関するPK/PD解析 |
| URI | https://www.jstage.jst.go.jp/article/jjphcs/41/6/41_404/_article/-char/ja http://mol.medicalonline.jp/en/journal/download?GoodsID=db5pharm/2015/004106/004&name=0404-0414j |
| Volume | 41 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | 医療薬学, 2015/06/10, Vol.41(6), pp.404-414 |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1882-1499 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0069027 issn: 1346-342X databaseCode: KQ8 dateStart: 20010101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpR3LahRBcIjxIoj4xPhiD3ZO2WRnpp83Z3YnBENkhQRyG3ZmZ5AFYzDJIZ6SDSgqqAdJEEzAB0TwgVcP4q8Io5vkL6zqnt2diIdVYWh6u6urq6q7t6pmuqst6ypPK3EjZrwcC9ks02YjLkepouWYRqDgeZIoHUh75gafmqPX59n80JHvhV1LK8vReHzvj-dK_mVUoQzGFU_J_sXI9pBCAeRhfCGFEYZ0oDEmgSKqRlRAApdIh_hKZ-Dhecar5VUe7VYBDMf9DZ7QGY8oyAiEkQFm4KeEEkkUJ15Vt7KJFxSAJfFsxBAw4leInMQqIMOHDCU-0FPVeCjxZLe5r0kFhE5eolROmPTr0yCBek3jFcRzNbqAmPs9u4YzdiarxPc1aoUt-yQy5NPrvWPEGp9pljkSA2TARMKGHgO0uhqERfvwQLYESnJGlG3gOeKXqg9mpO1oxm18NBiUelriukvPL5IhDTzgB9GxHhkwHqL4vsVmuC8s33mLK6RLkiZWSs2lQPR-gP0oP5eT7yJagx8eJFlzmTNeHURsunkVmCgoKJfyskv1FfSgv00Zekng6aqiVjPhxPLVW1RR1Fz3nFs71Bzh_V2RMk4xDm2rtXgrXhqn9niv1aHY5PnMDw1cSO2QYwLAYbcKDw-GLfBgjjqCc7xjZPpm0QEQoAIK3_Up2MOFFwSujR5JIcCcQhu1Z0CDcwL-cv-7PsdoT_o-B2OLcQDX1yt1pWai7CJ3E4d4A_uzBd4Yhtk4ftt8ITWRagrG5uxJ60TuJZY8w90pa6jVOG2N1k2Y-dWx0mz_1OTSWGm0VO8HoF89Y80cbO9k7S_Zxv1s42PWfpttPOys7XYebe21n-xtPdjf_JCtf4Kf-6_Wfn5-2tn-9uPry73n77L19webr7P1F1n7cX16ol7b333T2Xl21pqbDGarU-X82pRyy7WdCtqcrOFU0thJ9C4J12lQEUmhhEpd0Uhd5iYNaifgqaZpnDo04tRWcQSORCRScK_OWcMLdxaS81YpUYI1XcrArudUKBY5TabAuuNuhboRj0YsZcQWLprYOOHgM2LEunZI0mH-x7oUNiO2iGILcfmFGBFQ772lYYXqBA_nciUqzoX_6P6iday_ui9Zw8t3V5LL4F8sR1f0FP0FqNfx6g |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E9%9D%9E%E3%82%B9%E3%83%86%E3%83%AD%E3%82%A4%E3%83%89%E6%80%A7%E6%8A%97%E7%82%8E%E7%97%87%E8%96%AC%E3%81%AE%E6%8A%97%E8%A1%80%E5%B0%8F%E6%9D%BF%E4%BD%9C%E7%94%A8%E3%81%AB%E9%96%A2%E3%81%99%E3%82%8BPK%2FPD%E8%A7%A3%E6%9E%90&rft.jtitle=%E5%8C%BB%E7%99%82%E8%96%AC%E5%AD%A6&rft.au=%E8%B5%A4%E6%9C%A8%2C+%E7%A5%90%E8%B2%B4&rft.au=%E4%B8%8B%E6%9D%91%2C+%E6%96%89&rft.au=%E9%9D%92%E5%B1%B1%2C+%E9%9A%86%E5%A4%AB&rft.au=%E8%8D%92%E4%BA%95%2C+%E7%A2%A7&rft.date=2015-06-10&rft.pub=%E4%B8%80%E8%88%AC%E7%A4%BE%E5%9B%A3%E6%B3%95%E4%BA%BA%E6%97%A5%E6%9C%AC%E5%8C%BB%E7%99%82%E8%96%AC%E5%AD%A6%E4%BC%9A&rft.issn=1346-342X&rft.eissn=1882-1499&rft.volume=41&rft.issue=6&rft.spage=404&rft.epage=414&rft_id=info:doi/10.5649%2Fjjphcs.41.404&rft.externalDocID=article_jjphcs_41_6_41_404_article_char_ja |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1346-342X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1346-342X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1346-342X&client=summon |