IL-1ファミリーとIL-1受容体：歯周病疾患マーカーや治療薬としての可能性
[はじめに] 歯周病は歯周病原細菌の感染に伴う局所の炎症性骨破壊により, 歯を喪失する疾患である. 歯周病原細菌の内毒素(LPS)や莢膜多糖(CP)がin vitroの実験系において, 骨吸収活性や破骨細胞形成能を有することや, LPSやCPによる骨吸収や破骨細胞形成に, プロスタグランディンE2やインターロイキン-1 (IL-1)が関与していることが報告されている. 一方で, IL-1は骨芽細胞とのRANKL-RANKの接触を介することなく, 直接破骨細胞を分化・活性化することが報告されており, 歯周病の発症や進行にIL-1が深く関わると考えられている. IL-1ファミリーには, 代表的なア...
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| Published in | 日本歯周病学会会誌 Vol. 56; no. 3; pp. 272 - 280 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
特定非営利活動法人 日本歯周病学会
2014
日本歯周病学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0385-0110 1880-408X |
| DOI | 10.2329/perio.56.272 |
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| Abstract | [はじめに] 歯周病は歯周病原細菌の感染に伴う局所の炎症性骨破壊により, 歯を喪失する疾患である. 歯周病原細菌の内毒素(LPS)や莢膜多糖(CP)がin vitroの実験系において, 骨吸収活性や破骨細胞形成能を有することや, LPSやCPによる骨吸収や破骨細胞形成に, プロスタグランディンE2やインターロイキン-1 (IL-1)が関与していることが報告されている. 一方で, IL-1は骨芽細胞とのRANKL-RANKの接触を介することなく, 直接破骨細胞を分化・活性化することが報告されており, 歯周病の発症や進行にIL-1が深く関わると考えられている. IL-1ファミリーには, 代表的なアゴニストであるIL-1α, IL-1βや, アンタゴニストとしてのIL-1レセプターアンタゴニスト(IL-1Ra)などが含まれる. IL-1αとIL-1βはT細胞, B細胞の増殖促進, サイトカインの産生誘導, MMP産生, 破骨細胞の分化・活性化を有し, 細胞内シグナル伝達を引き起こすリガンドである. |
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| AbstractList | [はじめに] 歯周病は歯周病原細菌の感染に伴う局所の炎症性骨破壊により, 歯を喪失する疾患である. 歯周病原細菌の内毒素(LPS)や莢膜多糖(CP)がin vitroの実験系において, 骨吸収活性や破骨細胞形成能を有することや, LPSやCPによる骨吸収や破骨細胞形成に, プロスタグランディンE2やインターロイキン-1 (IL-1)が関与していることが報告されている. 一方で, IL-1は骨芽細胞とのRANKL-RANKの接触を介することなく, 直接破骨細胞を分化・活性化することが報告されており, 歯周病の発症や進行にIL-1が深く関わると考えられている. IL-1ファミリーには, 代表的なアゴニストであるIL-1α, IL-1βや, アンタゴニストとしてのIL-1レセプターアンタゴニスト(IL-1Ra)などが含まれる. IL-1αとIL-1βはT細胞, B細胞の増殖促進, サイトカインの産生誘導, MMP産生, 破骨細胞の分化・活性化を有し, 細胞内シグナル伝達を引き起こすリガンドである. |
| Author | 亀井, 英彦 伊澤, 有郎 神谷, 洋介 野口, 俊英 三谷, 章雄 水谷, 大樹 石原, 裕一 鈴木, 万里代 |
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| Copyright | 2014 特定非営利活動法人 日本歯周病学会 |
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| DOI | 10.2329/perio.56.272 |
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| References_xml | – reference: 35)Larsen CM, Faulenbach M, Vaag A, Ehses JA,Donath MY, Mandrup-Poulsen T：Sustained ef fects of interleukin-1 receptor antagonist treatment in type 2 diabetes. Diabetes care, 32：1663-1668,2009. – reference: 29) Ishihara Y, Zhang JB, Fakher M, Best AM,Schenkein HA, Barbour SE, Tew JG：Non-redun dant roles for interleukin-1 alpha and interleukin-1 beta in regulating human IgG2. Journal of periodontology, 72：1332-1339,2001. – reference: 4)Nishihara T, Ueda N, Amano K, Ishihara Y,Hayakawa H, Kuroyanagi T, Ohsaki Y, Nagata K, Noguchi T：Actinobacillus actinomycetemcomitans Y4 capsular-polysaccharide-like polysaccharide promotes osteoclast-like cell formation by interleukin-1 alpha production in mouse marrow cultures. Infection and immunity, 63：1893-1898, 1995. – reference: 8)Clark W, Jobanputra P, Barton P, Burls A：The clinical and cost-effectiveness of anakinra for the treatment of rheumatoid arthritis in adults：a systematic review and economic analysis. Health technology assessment, 8：iii-iv, ix-x, 1-105, 2004. – reference: 28)Ishibe T, Kimura A, Ishida Y, Takayasu T, Hayashi T, Tsuneyama K, Matsushima K, Sakata I, Mukaida N, Kondo T：Reduced acetaminophen-induced liver injury in mice by genetic disruption of IL-1 receptor antagonist. Laboratory investigation；a journal of technical methods and pathology, 89：68-79,2009. – reference: 13)Jouvenne P, Vannier E, Dinarello CA, Miossec P：Elevated levels of soluble interleukin-1 receptor type II and interleukin-1 receptor antagonist in patients with chronic arthritis：correlations with markers of inflammation and joint destruction. Arthritis and rheumatism, 41：1083-1089,1998. – reference: 3)Ueda N, Nishihara T, Ishihara Y, Amano K,Kuroyanagi T, Noguchi T：Role of prostaglandin in the formation of osteoclasts induced by capsular-like polysaccharide antigen of Actinobacillus actinomycetemcomitans strain Y4. Oral microbiology and immunology, 10：69-75, 1995. – reference: 33)Chevalier X, Giraudeau B, Conrozier T, Marliere J,Kiefer P, Goupille P：Safety study of intraarticular injection of interleukin 1 receptor antagonist in patients with painful knee osteoarthritis：a multicenter study. The Journal of rheumatology, 32：1317-1323, 2005. – reference: 10) Dinarello CA：Interleukin-1 and interleukin-1 antagonism. Blood, 77：1627-1652, 1991. – reference: 19) Barbour SE, Ishihara Y, Fakher M, Al-Darmaki S,Caven TH, Shelburne CP, Best AM, Schenkein HA, Tew JG：Monocyte differentiation in localized juvenile periodontitis is skewed toward the dendritic cell phenotype. Infection and immunity, 70：2780-2786, 2002. – reference: 22)Salvi GE, Brown CE, Fujihashi K, Kiyono H, Smith FW, Beck JD, Offenbacher S：Inflammatory media tors of the terminal dentition in adult and early onset periodontitis. Journal of periodontal research, 33：212-225, 1998. – reference: 24)Horai R, Saijo S, Tanioka H, Nakae S, Sudo K,Okahara A, Ikuse T, Asano M, Iwakura Y： Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice. The Journal of experimental medicine, 191：313-320,2000. – reference: 14)Attur MG, Dave M, Cipolletta C, Kang P, Goldring MB, Patel IR, Abramson SB, Amin AR：Reversal of autocrine and paracrine effects of interleukin 1 (IL-1) in human arthritis by type II IL-1 decoy receptor. Potential for pharmacological intervention. The Journal of biological chemistry, 275：40307-40315, 2000. – reference: 2)Takahashi T, Nishihara T, Ishihara Y, Amano K,Shibuya N, Moro I, Koga T：Murine macrophage interleukin-1 release by capsularlike serotype-specific polysaccharide antigens of Actinobacillus actinomycetemcomitans. Infection and immunity,59：18-23, 1991. – reference: 11)Smolen JS, Landewe R, Breedveld FC, Buch M,Burmester G, Dougados M, Emery P, Gaujoux-Viala C, Gossec L, Nam J, Ramiro S, Winthrop K, de Wit M,Aletaha D, Betteridge N, Bijlsma JW, Boers M,Buttgereit F, Combe B, Cutolo M, Damjanov N, Hazes JM, Kouloumas M, Kvien TK, Mariette X,Pavelka K, van Riel PL, Rubbert-Roth A,Scholte-Voshaar M, Scott DL, Sokka-Isler T, Wong JB, van der Heijde D：EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs：2013 update. Annals of the rheumatic diseases, 73：492-509,2014. – reference: 7) Dinarello CA：Interleukin-1, interleukin-1 recep tors and interleukin-1 receptor antagonist. International reviews of immunology, 16：457-499,1998. – reference: 37) Fearon WF, Fearon DT：Inflammation and cardiovascular disease：role of the interleukin-1 receptor antagonist. Circulation, 117：2577-2579,2008. – reference: 17) Suzuki M, Ishihara Y, Kamiya Y, Koide M, Fuma D,Fujita S, Matsumura Y, Suga T, Kamei H, Noguchi T：Soluble interleukin-1 receptor type II levels in gingival crevicular fluid in aggressive and chronic periodontitis. Journal of periodontology, 79：495-500,2008. – reference: 26)Sato A, Ohtaki H, Tsumuraya T, Song D, Ohara K,Asano M, Iwakura Y, Atsumi T, Shioda S： Interleukin-1 participates in the classical and alternative activation of microglia/macrophages after spinal cord injury. Journal of neuroinflammation, 9：65, 2012. – reference: 30) Izawa A, Ishihara Y, Mizutani H, Kobayashi S, Goto H, Okabe E, Takeda H, Ozawa Y, Kamiya Y, Sugita Y, Kubo K, Kamei H, Kikuchi T, Mitani A, Hayashi J,Nishihara T, Maeda H, Noguchi T：Inflammatory bone loss in experimental periodontitis induced by Aggregatibacter actinomycetemcomitans in interleukin-1 receptor antagonist knockout mice. Infection and immunity, 82：1904-1913, 2014. – reference: 21)Kikuchi T, Willis DL, Liu M, Purkall DB, Sukumar S,Barbour SE, Schenkein HA, Tew JG：Dendritic-NK cell interactions in P. gingivalis-specific responses. Journal of dental research, 84：858-862, 2005. – reference: 27) Marsh CB, Moore SA, Pope HA, Wewers MD：IL-1ra suppresses endotoxin-induced IL-1 beta and TNF-alpha release from mononuclear phagocytes. The American journal of physiology, 267：L39-L45,1994. – reference: 9) Greenfeder SA, Nunes P, Kwee L, Labow M, Chizzonite RA, Ju G：Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex. The Journal of biological chemistry, 270：13757-13765, 1995. – reference: 32)Furst DE：Anakinra：review of recombinant human interleukin-I receptor antagonist in the treat ment of rheumatoid arthritis. 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| Snippet | [はじめに] 歯周病は歯周病原細菌の感染に伴う局所の炎症性骨破壊により, 歯を喪失する疾患である. 歯周病原細菌の内毒素(LPS)や莢膜多糖(CP)がin vitroの実験系において,... |
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| SubjectTerms | IL-1 IL-1R IL-1Ra 実験的歯周炎 歯肉溝滲出液 破骨細胞形成 遺伝子多型 |
| Title | IL-1ファミリーとIL-1受容体：歯周病疾患マーカーや治療薬としての可能性 |
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