環境保健研究のジレンマ
「1. はじめに」環境保健はヒトの健康と環境の相互作用を解明する一学術分野である. 環境中に存在する有害因子(以下, 環境有害因子)には, 化学物質の曝露だけでなく, 廃棄物汚染, 越境汚染, 地球(および生活)環境変化に伴う温暖化(暑熱, 洪水・ゲリラ豪雨, 生物媒介感染症の拡大)や紫外線照射などが含まれる. これらがヒトの健康にどのような/どのように影響を与えるが環境保健の主たる研究目的であり, 途上国では金属鉱山・採掘や農薬撒布による健康リスクに関する研究が盛んにおこなわれているが, 先進国では環境による小児への健康影響に関心が向けられている. 1970年代後半に鉛による健康影響に関する...
Saved in:
| Published in | 日本衛生学雑誌 Vol. 73; no. 2; pp. 148 - 155 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人日本衛生学会
2018
日本衛生学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0021-5082 1882-6482 |
| DOI | 10.1265/jjh.73.148 |
Cover
| Abstract | 「1. はじめに」環境保健はヒトの健康と環境の相互作用を解明する一学術分野である. 環境中に存在する有害因子(以下, 環境有害因子)には, 化学物質の曝露だけでなく, 廃棄物汚染, 越境汚染, 地球(および生活)環境変化に伴う温暖化(暑熱, 洪水・ゲリラ豪雨, 生物媒介感染症の拡大)や紫外線照射などが含まれる. これらがヒトの健康にどのような/どのように影響を与えるが環境保健の主たる研究目的であり, 途上国では金属鉱山・採掘や農薬撒布による健康リスクに関する研究が盛んにおこなわれているが, 先進国では環境による小児への健康影響に関心が向けられている. 1970年代後半に鉛による健康影響に関する論文が産業保健専門誌に多数掲載されるようになり, 世界保健機関(WHO)は1984年に水道水中の鉛指針値(WHO guideline value)を50μg/Lとした. 1993年には, この指針値を一気に10μg/Lに下げた(わが国の鉛の水質基準を50μg/L以下にしたのは1992年, 10μg/L以下になったのは2004年である). |
|---|---|
| AbstractList | 「1. はじめに」環境保健はヒトの健康と環境の相互作用を解明する一学術分野である. 環境中に存在する有害因子(以下, 環境有害因子)には, 化学物質の曝露だけでなく, 廃棄物汚染, 越境汚染, 地球(および生活)環境変化に伴う温暖化(暑熱, 洪水・ゲリラ豪雨, 生物媒介感染症の拡大)や紫外線照射などが含まれる. これらがヒトの健康にどのような/どのように影響を与えるが環境保健の主たる研究目的であり, 途上国では金属鉱山・採掘や農薬撒布による健康リスクに関する研究が盛んにおこなわれているが, 先進国では環境による小児への健康影響に関心が向けられている. 1970年代後半に鉛による健康影響に関する論文が産業保健専門誌に多数掲載されるようになり, 世界保健機関(WHO)は1984年に水道水中の鉛指針値(WHO guideline value)を50μg/Lとした. 1993年には, この指針値を一気に10μg/Lに下げた(わが国の鉛の水質基準を50μg/L以下にしたのは1992年, 10μg/L以下になったのは2004年である). |
| Author | 苅田, 香苗 村田, 勝敬 前田, 恵理 岩田, 豊人 |
| Author_xml | – sequence: 1 fullname: 村田, 勝敬 organization: 秋田大学大学院医学系研究科環境保健学講座 – sequence: 1 fullname: 岩田, 豊人 organization: 秋田大学大学院医学系研究科環境保健学講座 – sequence: 1 fullname: 苅田, 香苗 organization: 杏林大学医学部衛生学公衆衛生学教室 – sequence: 1 fullname: 前田, 恵理 organization: 秋田大学大学院医学系研究科環境保健学講座 |
| BookMark | eNo1jcFKw0AURQepYK3d-Ad-QOqbeTOTycKFFK1CwY2uh8lkahLSVJK6cFnzB-K2IoILQUQQxJ0fE0t_w5Tq4t7HvfDO3SatfJI7QnYp9CiTYj9N456PPcrVBmlTpZgnuWIt0gZg1BOg2BbplmUSAkAgAoWqTfaWd--Lp-rne76YPS8f75cvn_Xsrb79qqvXuvqoq4cdsjkyWem6f7dDLo6Pzvsn3vBscNo_HHopQgAe53YUChChtUJBqDDyfcWZYSriESIFiVIKZFSqaBQxbsEYKoVCGQYRGocdMlhzxy5KrMkmeZbkTqeT6yJvdrWNuUtKl2gGVGkAH4FpoLQRbzIVAkH5fsAa0sGalJZTc-n0VZGMTXGjTTFNbNYg01j7qNnKVr__vY1NoVODv5bQa_k |
| ContentType | Journal Article |
| Copyright | 2018 日本衛生学会 |
| Copyright_xml | – notice: 2018 日本衛生学会 |
| CorporateAuthor | 秋田大学大学院医学系研究科環境保健学講座 杏林大学医学部衛生学公衆衛生学教室 |
| CorporateAuthor_xml | – name: 杏林大学医学部衛生学公衆衛生学教室 – name: 秋田大学大学院医学系研究科環境保健学講座 |
| DOI | 10.1265/jjh.73.148 |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Public Health |
| EISSN | 1882-6482 |
| EndPage | 155 |
| ExternalDocumentID | ch4eisei_2018_007302_011_0148_01553087792 article_jjh_73_2_73_148_article_char_ja |
| GroupedDBID | 123 2WC ALMA_UNASSIGNED_HOLDINGS CS3 E3Z EMOBN F5P JSF KQ8 MOJWN OK1 RJT SV3 |
| ID | FETCH-LOGICAL-j3090-44cfb505bcc580b83d77842a28d4d33106366532168dfd24c0aa165836b9d3ae3 |
| ISSN | 0021-5082 |
| IngestDate | Thu Jul 10 16:10:19 EDT 2025 Wed Sep 03 06:29:12 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | Japanese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-j3090-44cfb505bcc580b83d77842a28d4d33106366532168dfd24c0aa165836b9d3ae3 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/jjh/73/2/73_148/_article/-char/ja |
| PageCount | 8 |
| ParticipantIDs | medicalonline_journals_ch4eisei_2018_007302_011_0148_01553087792 jstage_primary_article_jjh_73_2_73_148_article_char_ja |
| PublicationCentury | 2000 |
| PublicationDate | 20180000 |
| PublicationDateYYYYMMDD | 2018-01-01 |
| PublicationDate_xml | – year: 2018 text: 20180000 |
| PublicationDecade | 2010 |
| PublicationTitle | 日本衛生学雑誌 |
| PublicationTitleAlternate | 日衛誌 |
| PublicationYear | 2018 |
| Publisher | 一般社団法人日本衛生学会 日本衛生学会 |
| Publisher_xml | – name: 一般社団法人日本衛生学会 – name: 日本衛生学会 |
| References | (12) Murata K, Weihe P, Budtz-Jørgensen E, Jørgensen PJ, Grandjean P. Delayed brainstem auditory evoked potential latencies in 14-year-old children exposed to methylmercury. J Pediatr 2004;144:177–183. (45) EFSA. Use of the benchmark dose approach in risk assessment: guidance of the Scientific Committee. EFSA Journal 2009;1150:1–72. (5) 村田勝敬.低濃度メチル水銀の神経発達影響に関する調査―フェロー諸島とセイシェル.熊谷嘉人,姫野誠一郎,渡辺知保(編),毒性の科学.東京:東京大学出版会,2014;171–175 (36) Sampei M, Dakeishi M, Wood DC, Murata K. Impact of total sleep duration on blood pressure in preschool children. Biomed Res 2006;27:111–115. (24) Sakamoto M, Chan HM, Domingo JL, Kubota M, Murata K. Changes in body burden of mercury, lead, arsenic, cadmium and selenium in infants during early lactation in comparison with placental transfer. Ecotoxicol Environ Saf 2012;84:179–184. (31) Goudarzi H, Nakajima S, Ikeno T, Sasaki S, Kobayashi S, Miyashita C, Ito S, Araki A, Nakazawa H, Kishi R. Prenatal exposure to perfluorinated chemicals and neurodevelopment in early infancy: The Hokkaido study. Sci Total Environ 2016;541:1002–1010. (3) Kawamoto T, Nitta H, Murata K, Toda E, Tsukamoto N, Hasegawa M, Yamagata Z, Kayama F, Kishi R, Ohya Y, Saito H, Sago H, Okuyama M, Ogata T, Yokoya S, Koresawa Y, Shibata Y, Nakayama S, Michikawa T, Takeuchi A, Satoh H, Working Group of the Epidemiological Research for Children’s Environmental Health. Rationale and study design of the Japan environmental and children’s study (JECS). BMC Public Health 2014;14:25. (33) Prpić I, Milardović A, Vlašić-Cicvarić I, Špiric Z, Nišević JR, Vukelić P, Tratnik JS, Mazej D, Horvat M. Prenatal exposure to low-level methylmercury alters the child’s fine motor skills at the age of 18 months. Environ Res 2017;152:369–374. (28) Hoenig JM, Heisey DM. The abuse of power: the pervasive fallacy of power calculations for data analysis. Am Stat 2001;55:19–24. (27) Chen JC, Brunner RL, Ren H, Wassertheil-Smoller S, Larson JC, Levine DW, Allison M, Naughton MJ, Stefanick ML. Sleep duration and risk of ischemic stroke in postmenopausal women. Stroke 2008;39:3185–3192. (30) Nakajima S, Saijo Y, Kato S, Sasaki S, Uno A, Kanagami N, Hirakawa H, Hori T, Tobiishi K, Todaka T, Nakamura Y, Yanagiya S, Sengoku Y, Iida T, Sata F, Kishi R. Effect of prenatal exposure to polychlorinated biphenyls and dioxins on mental and motor development in Japanese children at 6 months of age. Environ Health Perspect 2006;114:773–778. (34) Wasserman GA, Liu X, Parvez F, Ahsan H, Levy D, Factor-Litvak P, Kline J, van Geen A, Slavkovich V, Lolacono NJ, Cheng Z, Zheng Y, Graziano JH. Water manganese exposure and children’s intellectual function in Araihazar, Bangladesh. Environ Health Perspect 2006;114:124–129. (13) Debes F, Budtz-Jørgensen E, Weihe P, White RF, Grandjean P. Impact of prenatal methylmercury exposure on neurobehavioral function at age 14 years. Neurotoxicol Teratol 2006;28:627–632. (14) Davidson PW, Myers GJ, Cox C, Axtell C, Shamlaye C, Sloane-Reeves J, Cernichiari E, Needham L, Choi A, Wang Y, Berlin M, Clarkson TW. Effects of prenatal and postnatal methylmercury exposure from fish consumption on neurodevelopment: outcomes at 66 months of age in the Seychelles child development study. JAMA 1998;280:701–707. (9) Grandjean P, Weihe P, White RF, Debes F, Araki S, Yokoyama K, Murata K, Sørensen N, Dahl R, Jørgensen PJ. Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury. Neurotoxicol Teratol 1997;19:417–428. (42) Grandjean P. Seven deadly sins of environmental epidemiology and the virtues of precaution. Epidemiology 2008;19:158–162. (10) Sørensen N, Murata K, Budtz-Jørgensen E, Weihe P, Grandjean P. Prenatal methylmercury exposure as a cardiovascular risk factor at seven years of age. Epidemiology 1999;10:370–375. (46) EFSA. Scientific opinion on lead in food: EFSA Panel on contaminants in the food chain (CONTAM). EFSA Journal 2010;1570:1–147. (2) 環境省.小児の環境保健に関する懇談会報告書.2006.http://www.env.go.jp/chemi/report/h18-04 (26) Shankar A, Koh WP, Yuan JM, Lee HP, Yu MC. Sleep duration and coronary heart disease mortality among Chinese adults in Singapore: a population-based cohort study. Am J Epidemiol 2008;168:1367–1373. (29) 苅田香苗,坂本峰至,吉田 稔,龍田 希,仲井邦彦,岩井美幸,岩田豊人,前田恵理,柳沼 梢,佐藤 洋,村田勝敬.メチル水銀,水銀およびセレンに関する研究動向―疫学研究を中心に―.日本衛生学雑誌2016;71:236–251 (32) Tatsuta N, Suzuki K, Sugawara T, Nakai K, Hosokawa T, Satoh H. Comparison of Kyoto scale of psychological development and Bayley scales of infant development second edition among Japanese infants. J Spec Educ Res 2013;2:17–24. (16) Strain JJ, Davidson PW, Bonham MP, Duffy EM, Stokes-Riner A, Thurston SW, Wallace JM, Robson PJ, Shamlaye CF, Georger LA, Sloane-Reeves J, Cernichiari E, Canfield RL, Cox C, Huang LS, Janciuras J, Myers GJ, Clarkson TW. Associations of maternal long-chain polyunsaturated fatty acids, methyl mercury, and infant development in the Seychelles child development nutrition study. Neurotoxicology 2008;29:776–782. (7) Marsh DO, Clarkson TW, Cox C, Myers GJ, Amin-Zaki L, Al-Tikriti S. Fetal methylmercury poisoning. Relationship between concentration in single strands of maternal hair and child effects. Arch Neurol 1987;44:1017–1022. (41) Kobayashi S, Azumi K, Goudarzi H, Araki A, Miyashita C, Kobayashi S, Itoh S, Sasaki S, Ishizuka M, Nakazawa H, Ikeno T, Kishi R. Effects of prenatal perfluoroalkyl acid exposure on cord blood IGF2/H19 methylation and ponderal index: The Hokkaido study. J Expo Sci Environ Epidemiol 2017;27:251–259. (25) Menke A, Muntner P, Batuman V, Silbergeld EK, Guallar E. Blood lead below 0.48 micromol/L (10 microg/dL) and mortality among US adults. Circulation 2006;114:1388–1394. (8) National Research Council. Toxicological Effects of Methylmercury. Washington, DC: National Academy Press, 2000. (40) Tatsuta N, Nakai K, Iwai-Shimada M, Suzuki T, Satoh H, Murata K. Total mercury levels in hair of children aged 7 years before and after the Great East Japan earthquake. Sci Total Environ 2017;596–597:207–211. (49) Dakeishi M, Murata K, Tamura A, Iwata T. Relation between benchmark dose and no-observed-adverse-effect level in clinical research: effects of daily alcohol intake on blood pressure in Japanese salesmen. Risk Anal 2006;26:115–123. (6) Landrigan PJ, Schechter CB, Lipton JM, Fahs MC, Schwartz J. Environmental pollutants and disease in American children: estimates of morbidity, mortality, and costs for lead poisoning, asthma, cancer, and developmental disabilities. Environ Health Perspect 2002;110:721–728. (19) Tatsuta N, Murata K, Iwai-Shimada M, Yaginuma-Sakurai K, Satoh H, Nakai K. Psychomotor ability in children prenatally exposed to methylmercury: The 18-month follow-up of Tohoku study of child development. Tohoku J Exp Med 2017;242:1–8. (20) McMicheal AJ, Baghurst PA, Wigg NR, Vimpani GV, Robertson EF, Roberts RJ. Port Pirie cohort study: environmental exposure to lead and children’s abilities at the age of four years. N Engl J Med 1988;319:468–475. (4) 環境省エコチルWG基本設計班.子どもの健康と環境に関する全国調査(エコチル調査)基本計画.2010.https://www.env.go.jp/chemi/ceh/outline/data/kihonkeikaku.pdf (1) International Programme on Chemical Safety. Environmental Health Criteria 165—Inorganic Lead. Geneva: World Health Organization, 1995. (35) Sampei M, Murata K, Dakeishi M, Wood DC. Cardiac autonomic hypofunction in preschool children with short nocturnal sleep. Tohoku J Exp Med 2006;208:235–242. (50) Sakamoto M, Yasutake A, Domingo JL, Chan HM, Kubota M, Murata K. Relationships between trace element concentrations in chorionic tissue of placenta and umbilical cord tissue: potential use as indicators for prenatal exposure. Environ Int 2013;60:106–111. (44) Crump KS. A new method for determining allowable daily intakes. Fundam Appl Toxicol 1984;4:854–871. (22) Jusko TA, Henderson CR, Lanphear BP, Cory-Slechta DA, Parsons PJ, Cnafiled RL. Blood lead concentrations <10 microg/dL and child intelligence at 6 years of age. Environ Health Perspect 2008;116:243–248. (38) Tatsuta N, Kurokawa N, Nakai K, Suzuki K, Iwai-Shimada M, Murata K, Satoh H. Effects of intrauterine exposures to polychlorinated biphenyls, methylmercury, and lead on birth weight in Japanese male and female newborns. Environ Health Prev Med 2017;22:39. (18) Suzuki K, Nakai K, Sugawara T, Nakamura T, Ohba T, Shimada M, Hosokawa T, Okamura K, Sakai T, Kurokawa N, Murata K, Satoh C, Satoh H. Neurobehavioral effects of prenatal exposure to methylmercury and PCBs and seafood intake: Neonatal behavioral assessment scale results of Tohoku study of child development. Environ Res 2010;110:699–704. (15) Myers GJ, Davidson PW, Cox C, Shamlaye CF, Palumbo D, Cernichiari E, Sloane-Reeves J, Wilding GE, Kost J, Huang LS, Clarkson TW. Prenatal methylmercury exposure from ocean fish consumption in the Seychelles child development study. Lancet 2003;361:1686–1692. (17) 村田勝敬,吉田 稔,坂本峰至,岩井美幸,柳沼 梢,龍田 希,岩田豊人,苅田香苗,仲井邦彦.メチル水銀毒性に関する疫学的研究の動向.日本衛生学雑誌2011;66:682–695 (48) EFSA. Scientific Committee. Update: use of the benchmark dose approach in risk assessment. EFSA Journal 2017;15:4658. (21) Baghurst PA, McMichael AJ, Wigg NR, Vimpani GV, Robertson EF, Roberts RJ, Tong SL. Environmental exposure to lead and children’s intelligence at the age of seven years. N Engl J Med 1992;316:1279–1284. (11) Grandjean P, Murata K, Budtz-Jørgensen E, Weihe P. Cardiac autonomic activity in methylmercury neurotoxicity: 14-year follow-up of a Faroese birth. J Pediatr 2004;144:169–176. (23) Yorifuji T, Debes F, Weihe P, Grandjean P. Prenatal exposure to lead and cognitive deficit in 7- and 14-year-old children in the presence of concomitant exposure to similar molar concentration of methylmercury. Neurotoxicol Teratol 2011;33:205–211. (39) Tanaka O, Maeda E, Fushimi M, Iwata T, Shimizu T, Saito S, Murata K. Precarious employment is not associated with increased depressive symptoms: a cross-sectional study in care service workers of Japan. Tohoku J Exp Med 2017;243:19–26. (43) MacMahon B, Pugh TF. Epidemiology: Principles and Methods. Boston: Little, Brown and Co., 1970. (37) 村田勝敬,嶽石美和子.胎児性メチル水銀曝露による小児神経発達影響__Faroe研 |
| References_xml | – reference: (37) 村田勝敬,嶽石美和子.胎児性メチル水銀曝露による小児神経発達影響__Faroe研究を中心に.日本衛生学雑誌2002;57:564–570. – reference: (36) Sampei M, Dakeishi M, Wood DC, Murata K. Impact of total sleep duration on blood pressure in preschool children. Biomed Res 2006;27:111–115. – reference: (16) Strain JJ, Davidson PW, Bonham MP, Duffy EM, Stokes-Riner A, Thurston SW, Wallace JM, Robson PJ, Shamlaye CF, Georger LA, Sloane-Reeves J, Cernichiari E, Canfield RL, Cox C, Huang LS, Janciuras J, Myers GJ, Clarkson TW. Associations of maternal long-chain polyunsaturated fatty acids, methyl mercury, and infant development in the Seychelles child development nutrition study. Neurotoxicology 2008;29:776–782. – reference: (39) Tanaka O, Maeda E, Fushimi M, Iwata T, Shimizu T, Saito S, Murata K. Precarious employment is not associated with increased depressive symptoms: a cross-sectional study in care service workers of Japan. Tohoku J Exp Med 2017;243:19–26. – reference: (32) Tatsuta N, Suzuki K, Sugawara T, Nakai K, Hosokawa T, Satoh H. Comparison of Kyoto scale of psychological development and Bayley scales of infant development second edition among Japanese infants. J Spec Educ Res 2013;2:17–24. – reference: (10) Sørensen N, Murata K, Budtz-Jørgensen E, Weihe P, Grandjean P. Prenatal methylmercury exposure as a cardiovascular risk factor at seven years of age. Epidemiology 1999;10:370–375. – reference: (49) Dakeishi M, Murata K, Tamura A, Iwata T. Relation between benchmark dose and no-observed-adverse-effect level in clinical research: effects of daily alcohol intake on blood pressure in Japanese salesmen. Risk Anal 2006;26:115–123. – reference: (44) Crump KS. A new method for determining allowable daily intakes. Fundam Appl Toxicol 1984;4:854–871. – reference: (1) International Programme on Chemical Safety. Environmental Health Criteria 165—Inorganic Lead. Geneva: World Health Organization, 1995. – reference: (29) 苅田香苗,坂本峰至,吉田 稔,龍田 希,仲井邦彦,岩井美幸,岩田豊人,前田恵理,柳沼 梢,佐藤 洋,村田勝敬.メチル水銀,水銀およびセレンに関する研究動向―疫学研究を中心に―.日本衛生学雑誌2016;71:236–251. – reference: (15) Myers GJ, Davidson PW, Cox C, Shamlaye CF, Palumbo D, Cernichiari E, Sloane-Reeves J, Wilding GE, Kost J, Huang LS, Clarkson TW. Prenatal methylmercury exposure from ocean fish consumption in the Seychelles child development study. Lancet 2003;361:1686–1692. – reference: (24) Sakamoto M, Chan HM, Domingo JL, Kubota M, Murata K. Changes in body burden of mercury, lead, arsenic, cadmium and selenium in infants during early lactation in comparison with placental transfer. Ecotoxicol Environ Saf 2012;84:179–184. – reference: (45) EFSA. Use of the benchmark dose approach in risk assessment: guidance of the Scientific Committee. EFSA Journal 2009;1150:1–72. – reference: (20) McMicheal AJ, Baghurst PA, Wigg NR, Vimpani GV, Robertson EF, Roberts RJ. Port Pirie cohort study: environmental exposure to lead and children’s abilities at the age of four years. N Engl J Med 1988;319:468–475. – reference: (42) Grandjean P. Seven deadly sins of environmental epidemiology and the virtues of precaution. Epidemiology 2008;19:158–162. – reference: (19) Tatsuta N, Murata K, Iwai-Shimada M, Yaginuma-Sakurai K, Satoh H, Nakai K. Psychomotor ability in children prenatally exposed to methylmercury: The 18-month follow-up of Tohoku study of child development. Tohoku J Exp Med 2017;242:1–8. – reference: (3) Kawamoto T, Nitta H, Murata K, Toda E, Tsukamoto N, Hasegawa M, Yamagata Z, Kayama F, Kishi R, Ohya Y, Saito H, Sago H, Okuyama M, Ogata T, Yokoya S, Koresawa Y, Shibata Y, Nakayama S, Michikawa T, Takeuchi A, Satoh H, Working Group of the Epidemiological Research for Children’s Environmental Health. Rationale and study design of the Japan environmental and children’s study (JECS). BMC Public Health 2014;14:25. – reference: (28) Hoenig JM, Heisey DM. The abuse of power: the pervasive fallacy of power calculations for data analysis. Am Stat 2001;55:19–24. – reference: (48) EFSA. Scientific Committee. Update: use of the benchmark dose approach in risk assessment. EFSA Journal 2017;15:4658. – reference: (27) Chen JC, Brunner RL, Ren H, Wassertheil-Smoller S, Larson JC, Levine DW, Allison M, Naughton MJ, Stefanick ML. Sleep duration and risk of ischemic stroke in postmenopausal women. Stroke 2008;39:3185–3192. – reference: (33) Prpić I, Milardović A, Vlašić-Cicvarić I, Špiric Z, Nišević JR, Vukelić P, Tratnik JS, Mazej D, Horvat M. Prenatal exposure to low-level methylmercury alters the child’s fine motor skills at the age of 18 months. Environ Res 2017;152:369–374. – reference: (18) Suzuki K, Nakai K, Sugawara T, Nakamura T, Ohba T, Shimada M, Hosokawa T, Okamura K, Sakai T, Kurokawa N, Murata K, Satoh C, Satoh H. Neurobehavioral effects of prenatal exposure to methylmercury and PCBs and seafood intake: Neonatal behavioral assessment scale results of Tohoku study of child development. Environ Res 2010;110:699–704. – reference: (6) Landrigan PJ, Schechter CB, Lipton JM, Fahs MC, Schwartz J. Environmental pollutants and disease in American children: estimates of morbidity, mortality, and costs for lead poisoning, asthma, cancer, and developmental disabilities. Environ Health Perspect 2002;110:721–728. – reference: (12) Murata K, Weihe P, Budtz-Jørgensen E, Jørgensen PJ, Grandjean P. Delayed brainstem auditory evoked potential latencies in 14-year-old children exposed to methylmercury. J Pediatr 2004;144:177–183. – reference: (23) Yorifuji T, Debes F, Weihe P, Grandjean P. Prenatal exposure to lead and cognitive deficit in 7- and 14-year-old children in the presence of concomitant exposure to similar molar concentration of methylmercury. Neurotoxicol Teratol 2011;33:205–211. – reference: (4) 環境省エコチルWG基本設計班.子どもの健康と環境に関する全国調査(エコチル調査)基本計画.2010.https://www.env.go.jp/chemi/ceh/outline/data/kihonkeikaku.pdf – reference: (11) Grandjean P, Murata K, Budtz-Jørgensen E, Weihe P. Cardiac autonomic activity in methylmercury neurotoxicity: 14-year follow-up of a Faroese birth. J Pediatr 2004;144:169–176. – reference: (25) Menke A, Muntner P, Batuman V, Silbergeld EK, Guallar E. Blood lead below 0.48 micromol/L (10 microg/dL) and mortality among US adults. Circulation 2006;114:1388–1394. – reference: (35) Sampei M, Murata K, Dakeishi M, Wood DC. Cardiac autonomic hypofunction in preschool children with short nocturnal sleep. Tohoku J Exp Med 2006;208:235–242. – reference: (41) Kobayashi S, Azumi K, Goudarzi H, Araki A, Miyashita C, Kobayashi S, Itoh S, Sasaki S, Ishizuka M, Nakazawa H, Ikeno T, Kishi R. Effects of prenatal perfluoroalkyl acid exposure on cord blood IGF2/H19 methylation and ponderal index: The Hokkaido study. J Expo Sci Environ Epidemiol 2017;27:251–259. – reference: (46) EFSA. Scientific opinion on lead in food: EFSA Panel on contaminants in the food chain (CONTAM). EFSA Journal 2010;1570:1–147. – reference: (21) Baghurst PA, McMichael AJ, Wigg NR, Vimpani GV, Robertson EF, Roberts RJ, Tong SL. Environmental exposure to lead and children’s intelligence at the age of seven years. N Engl J Med 1992;316:1279–1284. – reference: (47) 村田勝敬,苅田香苗,堀口兵剛,岩田豊人,広瀬明彦.ベンチマークドース法の臨床的基準をもつ健康影響指標への適用.産業衛生学雑誌2011;53:67–77. – reference: (17) 村田勝敬,吉田 稔,坂本峰至,岩井美幸,柳沼 梢,龍田 希,岩田豊人,苅田香苗,仲井邦彦.メチル水銀毒性に関する疫学的研究の動向.日本衛生学雑誌2011;66:682–695. – reference: (13) Debes F, Budtz-Jørgensen E, Weihe P, White RF, Grandjean P. Impact of prenatal methylmercury exposure on neurobehavioral function at age 14 years. Neurotoxicol Teratol 2006;28:627–632. – reference: (22) Jusko TA, Henderson CR, Lanphear BP, Cory-Slechta DA, Parsons PJ, Cnafiled RL. Blood lead concentrations <10 microg/dL and child intelligence at 6 years of age. Environ Health Perspect 2008;116:243–248. – reference: (34) Wasserman GA, Liu X, Parvez F, Ahsan H, Levy D, Factor-Litvak P, Kline J, van Geen A, Slavkovich V, Lolacono NJ, Cheng Z, Zheng Y, Graziano JH. Water manganese exposure and children’s intellectual function in Araihazar, Bangladesh. Environ Health Perspect 2006;114:124–129. – reference: (38) Tatsuta N, Kurokawa N, Nakai K, Suzuki K, Iwai-Shimada M, Murata K, Satoh H. Effects of intrauterine exposures to polychlorinated biphenyls, methylmercury, and lead on birth weight in Japanese male and female newborns. Environ Health Prev Med 2017;22:39. – reference: (26) Shankar A, Koh WP, Yuan JM, Lee HP, Yu MC. Sleep duration and coronary heart disease mortality among Chinese adults in Singapore: a population-based cohort study. Am J Epidemiol 2008;168:1367–1373. – reference: (2) 環境省.小児の環境保健に関する懇談会報告書.2006.http://www.env.go.jp/chemi/report/h18-04/ – reference: (7) Marsh DO, Clarkson TW, Cox C, Myers GJ, Amin-Zaki L, Al-Tikriti S. Fetal methylmercury poisoning. Relationship between concentration in single strands of maternal hair and child effects. Arch Neurol 1987;44:1017–1022. – reference: (40) Tatsuta N, Nakai K, Iwai-Shimada M, Suzuki T, Satoh H, Murata K. Total mercury levels in hair of children aged 7 years before and after the Great East Japan earthquake. Sci Total Environ 2017;596–597:207–211. – reference: (43) MacMahon B, Pugh TF. Epidemiology: Principles and Methods. Boston: Little, Brown and Co., 1970. – reference: (14) Davidson PW, Myers GJ, Cox C, Axtell C, Shamlaye C, Sloane-Reeves J, Cernichiari E, Needham L, Choi A, Wang Y, Berlin M, Clarkson TW. Effects of prenatal and postnatal methylmercury exposure from fish consumption on neurodevelopment: outcomes at 66 months of age in the Seychelles child development study. JAMA 1998;280:701–707. – reference: (8) National Research Council. Toxicological Effects of Methylmercury. Washington, DC: National Academy Press, 2000. – reference: (30) Nakajima S, Saijo Y, Kato S, Sasaki S, Uno A, Kanagami N, Hirakawa H, Hori T, Tobiishi K, Todaka T, Nakamura Y, Yanagiya S, Sengoku Y, Iida T, Sata F, Kishi R. Effect of prenatal exposure to polychlorinated biphenyls and dioxins on mental and motor development in Japanese children at 6 months of age. Environ Health Perspect 2006;114:773–778. – reference: (50) Sakamoto M, Yasutake A, Domingo JL, Chan HM, Kubota M, Murata K. Relationships between trace element concentrations in chorionic tissue of placenta and umbilical cord tissue: potential use as indicators for prenatal exposure. Environ Int 2013;60:106–111. – reference: (31) Goudarzi H, Nakajima S, Ikeno T, Sasaki S, Kobayashi S, Miyashita C, Ito S, Araki A, Nakazawa H, Kishi R. Prenatal exposure to perfluorinated chemicals and neurodevelopment in early infancy: The Hokkaido study. Sci Total Environ 2016;541:1002–1010. – reference: (5) 村田勝敬.低濃度メチル水銀の神経発達影響に関する調査―フェロー諸島とセイシェル.熊谷嘉人,姫野誠一郎,渡辺知保(編),毒性の科学.東京:東京大学出版会,2014;171–175. – reference: (9) Grandjean P, Weihe P, White RF, Debes F, Araki S, Yokoyama K, Murata K, Sørensen N, Dahl R, Jørgensen PJ. Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury. Neurotoxicol Teratol 1997;19:417–428. |
| SSID | ssib000959838 ssib050757847 ssib058493782 ssib000872075 ssib017172182 ssib002222520 ssj0061901 ssib002484643 ssib002484642 |
| Score | 2.1678958 |
| Snippet | 「1. はじめに」環境保健はヒトの健康と環境の相互作用を解明する一学術分野である. 環境中に存在する有害因子(以下, 環境有害因子)には, 化学物質の曝露だけでなく, 廃棄物... |
| SourceID | medicalonline jstage |
| SourceType | Publisher |
| StartPage | 148 |
| SubjectTerms | リスク評価 出生コホート研究 環境保健研究 用量-反応関係 臨界濃度推定 |
| Title | 環境保健研究のジレンマ |
| URI | https://www.jstage.jst.go.jp/article/jjh/73/2/73_148/_article/-char/ja http://mol.medicalonline.jp/library/journal/download?GoodsID=ch4eisei/2018/007302/011&name=0148-0155j |
| Volume | 73 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | 日本衛生学雑誌, 2018, Vol.73(2), pp.148-155 |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1882-6482 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0061901 issn: 0021-5082 databaseCode: KQ8 dateStart: 19460101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3NaxUxEA-1XoQifmL9okLnuHXzsdnk5u57W4oHQWiht5D9eLQPbMW2F2_1_QfiVRHBgyAiCOLNP-ZZ-m84SbZvt-ihVViWIZlkM5ls8pvZZJaQ5ZFVjaqpxsFb2kiULI2slWVUWRd4MpYVXm63xRO5tiEebyabcxeWe7uWDvbLlerlX8-V_ItWMQ316k7JnkOzs0oxAWnUL95Rw3g_k46hSEEzyGMoEsgYKA6FgHwV9NClKApZ4niyGLTwhIZcQsF9VuEJLK48wSEbtETOW0IXffAKhQSd-jqRGHh-BRkFnfuWCNCrviVDyPAp2qVr6nkyUDN3rC899Dm-UGi-yn2rMQsr6PEmkDPX7o5XQU5BZV7UDDpHg69Fgxr2eKWTNPedoGNQsuNV7okq6fFq12qt26ywn_fEIdLO3m7wnrMXsO4B6Ky_OjAaIWA9tTqEH620bwHrTfU0RAhtUQMNwYb_WJCYdLE7xuOtlZSvzIqcCvBdbYlme6_ZNk4Y4z6dxszgtGucs9eEHzupNNUINC4y53VyWw-e9kF0yuI-CNSJ7n8LZ86k74wCmjqrv4tohAYBztqdUYmIFCGrmgVhkw4yho1SoXfaIL8o2cNOLgRwYzRnXJyKhWfhE2MI9dJDa-tXyOXWzFrKwjtzlcyN7TWyEHzUS-Ho3XXy4Pj116MPk18_3x4dfjx-_-b40_fp4Zfpqx_Tyefp5Nt08u4G2Vgt1gdrUfvLkGjMYx1HQlSjEkF9WVWJikvF6xRlY5apWtQcTRnJpUw4o1LVo5qJKraWIgjnstQ1tw2_SeZ3dneaW2SJ1iV2ZF3XvKIiEY2uVZloixaRpaJho0Uig8TmeYgLY9p5wGCvmJQb5m5OhSfp7hylGdtF8uhUD5l2RtkzZx4Jt_-_ijvkkmMJ3sS7ZH7_xUFzD_H1fnnfD6_f9RyalA |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E7%92%B0%E5%A2%83%E4%BF%9D%E5%81%A5%E7%A0%94%E7%A9%B6%E3%81%AE%E3%82%B8%E3%83%AC%E3%83%B3%E3%83%9E&rft.jtitle=%E6%97%A5%E6%9C%AC%E8%A1%9B%E7%94%9F%E5%AD%A6%E9%9B%91%E8%AA%8C&rft.au=%E6%9D%91%E7%94%B0%E5%8B%9D%E6%95%AC&rft.au=%E5%B2%A9%E7%94%B0%E8%B1%8A%E4%BA%BA&rft.au=%E5%89%8D%E7%94%B0%E6%81%B5%E7%90%86&rft.au=%E8%8B%85%E7%94%B0%E9%A6%99%E8%8B%97&rft.date=2018&rft.pub=%E6%97%A5%E6%9C%AC%E8%A1%9B%E7%94%9F%E5%AD%A6%E4%BC%9A&rft.issn=0021-5082&rft.volume=73&rft.issue=2&rft.spage=148&rft.epage=155&rft_id=info:doi/10.1265%2Fjjh.73.148&rft.externalDocID=ch4eisei_2018_007302_011_0148_01553087792 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-5082&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-5082&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-5082&client=summon |