歯周病と骨粗鬆症のクロストーク
「はじめに」骨組織は, 骨吸収と骨形成のバランスにより調節されている. それらのバランス調節は, 互いにあたかも連絡を取り合っているかのようにみえるため, この現象は, 骨代謝共役(カップリング)と呼ばれる. 骨粗鬆症はこの骨代謝共役が破綻し, 骨吸収が骨形成を凌駕するために発症する. 骨芽細胞由来の破骨細胞分化因子であるRANKL(receptor activator of NF-κB ligand)とRANKLのデコイ受容体であるオステオプロテゲリン(Osteoprotegerin:OPG)の発見により, 現在では, RANKL中和抗体が骨粗鬆症・癌の骨転移・関節リウマチ患者の骨びらんなど...
Saved in:
| Published in | 日本歯周病学会会誌 Vol. 66; no. 1; pp. 9 - 16 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
特定非営利活動法人 日本歯周病学会
31.03.2024
日本歯周病学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0385-0110 1880-408X |
| DOI | 10.2329/perio.66.9 |
Cover
| Abstract | 「はじめに」骨組織は, 骨吸収と骨形成のバランスにより調節されている. それらのバランス調節は, 互いにあたかも連絡を取り合っているかのようにみえるため, この現象は, 骨代謝共役(カップリング)と呼ばれる. 骨粗鬆症はこの骨代謝共役が破綻し, 骨吸収が骨形成を凌駕するために発症する. 骨芽細胞由来の破骨細胞分化因子であるRANKL(receptor activator of NF-κB ligand)とRANKLのデコイ受容体であるオステオプロテゲリン(Osteoprotegerin:OPG)の発見により, 現在では, RANKL中和抗体が骨粗鬆症・癌の骨転移・関節リウマチ患者の骨びらんなどの治療薬として臨床応用されるに至った. OPG遺伝子欠損マウスは, 重度の骨粗鬆症を呈すると共に, 歯槽骨吸収が著明に認められ, 抗RANKL中和抗体やビスホスホネートを投与すると, 歯槽骨の再生が劇的に認められた. |
|---|---|
| AbstractList | 「はじめに」骨組織は, 骨吸収と骨形成のバランスにより調節されている. それらのバランス調節は, 互いにあたかも連絡を取り合っているかのようにみえるため, この現象は, 骨代謝共役(カップリング)と呼ばれる. 骨粗鬆症はこの骨代謝共役が破綻し, 骨吸収が骨形成を凌駕するために発症する. 骨芽細胞由来の破骨細胞分化因子であるRANKL(receptor activator of NF-κB ligand)とRANKLのデコイ受容体であるオステオプロテゲリン(Osteoprotegerin:OPG)の発見により, 現在では, RANKL中和抗体が骨粗鬆症・癌の骨転移・関節リウマチ患者の骨びらんなどの治療薬として臨床応用されるに至った. OPG遺伝子欠損マウスは, 重度の骨粗鬆症を呈すると共に, 歯槽骨吸収が著明に認められ, 抗RANKL中和抗体やビスホスホネートを投与すると, 歯槽骨の再生が劇的に認められた. |
| Author | 中村, 美どり 吉成, 伸夫 田口, 明 小出, 雅則 宇田川, 信之 |
| Author_xml | – sequence: 1 fullname: 小出, 雅則 organization: 松本歯科大学総合歯科医学研究所 – sequence: 1 fullname: 田口, 明 organization: 松本歯科大学歯科放射線学講座 – sequence: 1 fullname: 中村, 美どり organization: 松本歯科大学総合歯科医学研究所 – sequence: 1 fullname: 宇田川, 信之 organization: 松本歯科大学総合歯科医学研究所 – sequence: 1 fullname: 吉成, 伸夫 organization: 松本歯科大学歯科保存学講座（歯周） |
| BookMark | eNo9UL1KA0EYXCSCMabxPS5--3Ob3cJCgkYhYKNgt-xt9vSOy124i4VlEvxprfIKQYwBO8G3WTTkLVyJWHwzzBQzzLeLanmRW4T2MbQIJfJgaMukaHHekluojoWAgIG4qqE6UBEGgDHsoGZVJREAiDYBKuso-F4sv57nq9m9G8_XL_PV-2z9-rCaPbrxm5ss3XThJh9u-uSmn17uoe1YZ5Vt_nEDXZ4cX3ROg95596xz1AtSCm0ITEx5pLUxxrYBuIxiQSHUlrMYGMMWMOXEhNxYEYLF0BfeJwwTTqRg_Yg2UHeTO7D9xOisyLMktyotbsvc9yozlH5sVigChClfwQF7Iv5AesCcUc44JT7pcJOUViN9bdWwTAa6vFO6HCUm8_r3Z4pzhX9B_vvmRpcq1fQHg5t1sw |
| ContentType | Journal Article |
| Copyright | 2024 特定非営利活動法人 日本歯周病学会 |
| Copyright_xml | – notice: 2024 特定非営利活動法人 日本歯周病学会 |
| CorporateAuthor | 松本歯科大学歯科保存学講座(歯周 松本歯科大学生化学講座 松本歯科大学総合歯科医学研究所 松本歯科大学歯科放射線学講座 |
| CorporateAuthor_xml | – name: 松本歯科大学歯科保存学講座(歯周 – name: 松本歯科大学生化学講座 – name: 松本歯科大学総合歯科医学研究所 – name: 松本歯科大学歯科放射線学講座 |
| DOI | 10.2329/perio.66.9 |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Dentistry |
| EISSN | 1880-408X |
| EndPage | 16 |
| ExternalDocumentID | cp9perlo_2024_006601_002_0009_00164364632 article_perio_66_1_66_9_article_char_ja |
| GroupedDBID | 123 2WC ALMA_UNASSIGNED_HOLDINGS CS3 F5P JSF KQ8 MOJWN OK1 RJT ABJNI |
| ID | FETCH-LOGICAL-j3070-cf36baaccce70069bf8305ae64f0441e01362c56ce850e10d8f04241262984db3 |
| ISSN | 0385-0110 |
| IngestDate | Thu Jul 10 16:10:34 EDT 2025 Wed Sep 03 06:31:14 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | Japanese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-j3070-cf36baaccce70069bf8305ae64f0441e01362c56ce850e10d8f04241262984db3 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/perio/66/1/66_9/_article/-char/ja |
| PageCount | 8 |
| ParticipantIDs | medicalonline_journals_cp9perlo_2024_006601_002_0009_00164364632 jstage_primary_article_perio_66_1_66_9_article_char_ja |
| PublicationCentury | 2000 |
| PublicationDate | 2024/03/31 |
| PublicationDateYYYYMMDD | 2024-03-31 |
| PublicationDate_xml | – month: 03 year: 2024 text: 2024/03/31 day: 31 |
| PublicationDecade | 2020 |
| PublicationTitle | 日本歯周病学会会誌 |
| PublicationTitleAlternate | 日歯周誌 |
| PublicationYear | 2024 |
| Publisher | 特定非営利活動法人 日本歯周病学会 日本歯周病学会 |
| Publisher_xml | – name: 特定非営利活動法人 日本歯周病学会 – name: 日本歯周病学会 |
| References | 13) Koide M, Yamashita T, Murakami K, Uehara S, Nakamura K, Nakamura M, Matsushita M, Ara T, Yasuda H, Penninger JM, Takahashi N, Udagawa N, Kobayashi Y: Sclerostin expression in trabecular bone is downregulated by osteoclasts. Sci Rep, 10: 13751, 2020. 24) Taguchi A, Shiraki M, Sugimoto T, Ohta H, Soen S, Japan Osteoporosis Society: Lack of cooperation between physicians and dentists during osteoporosis treatment may increase fractures and osteonecrosis of the jaw. Curr Med Res Opin, 32: 1261-1268, 2016. 23) Penoni DC, Torres SR, Farias MLF, Fernandes TM, Luiz RR, Leão ATT: Association of osteoporosis and bone medication with the periodontal condition in elderly women. Osteoporos Int, 27: 1887-1896, 2016. 27) Mau LP, Kuan YC, Tsai YW, Lin JJ, Huynh-Ba G, Weng PW, Shieh YS, Cheng WC, Huang RY: Patients with chronic periodontitis present increased risk for osteoporosis: A population-based cohort study in Taiwan. J Periodontal Res, 52: 922-929, 2017. 7) Xu S, Zhang G, Guo JF, Tan YH: Associations between osteoporosis and risk of periodontitis: A pooled analysis of observational studies. Oral Dis, 27: 357-369, 2021. 14) Koide M, Yamashita T, Nakamura K, Yasuda H, Udagawa N, Kobayashi Y: Evidence for the major contribution of remodeling-based bone formation in sclerostin-deficient mice. Bone, 160: 116401, 2022. 26) Anbinder AL, Moraes RM, Lima GMG, Oliveira FE, Campos DRC, Rossoni RD, Oliveira LD, Junqueira JC, Ma Y, Elefteriou F: Periodontal disease exacerbates systemic ovariectomy-induced bone loss in mice. Bone, 83: 241-247, 2016. 10) Takahashi N, Akatsu T, Udagawa N, Sasaki T, Yamaguchi A, Moseley JM, Martin TJ, Suda T: Osteoblastic cells are involved in osteoclast formation. Endocrinology, 123: 2600-2602, 1988. 22) Taguchi A, Shiraki M, Tanaka S, Ohshige H, Nakamura T: Improved periodontal disease and prevention of tooth loss in osteoporosis patients receiving once-yearly zoledronic acid: a randomized clinical trial. Menopause, 26: 1277-1283, 2019. 9) Udagawa N, Takahashi N, Akatsu T, Tanaka H, Sasaki T, Nishihara T, Koga T, Martin TJ, Suda T: Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells. Proc Natl Acid Sci, 87: 7260-7264, 1990. 20) Ji S, Jin Tak Y, Han HD, Kim YJ, Lee SY, Lee JG, Jeong DW, Kim MJ: Low bone mineral density is associated with tooth loss in postmenopausal women: A nationwide representative study in Korea. J Womens Health (Larchmt), 25: 1159-1165, 2016. 5) Taguchi A, Urano T, Nakamura Y, Shiraki M: Increased Risk of Tooth Loss in Postmenopausal Women With Prevalent Vertebral Fractures.: An Observational Study. JBMR Plus, 7: e10822, 2023. 1) Yasuda H, Shima N, Nakagawa N, Yamaguchi K, Kinosaki M, Mochizuki S, Tomoyasu A, Yano K, Goto M, Murakami A, Tsuda E, Morinaga T, Higashio K, Udagawa N, Takahashi N, Suda T: Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci USA, 95: 3597-3602, 1998. 2) Mizuno A, Amizuka N, Irie K, Murakami A, Fujise N, Kanno T, Sato Y, Nakagawa N, Yasuda H, Mochizuki S, Gomibuchi T, Yano K, Shima N, Washida N, Tsuda E, Morinaga T, Higashio K, Ozawa H: Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin. Biochem Biophys Res Commum, 247: 610-615, 1998. 8) Taguchi A, Uemura Y, Tanaka S, Ohta H, Mori S, Hagino H, Shiraki M, Nakamura T, Soen S, Adequate Treatment of Osteoporosis (A-TOP) research group: Influence of symptomatic periodontal disease on changes in skeletal bone density during medication therapy for osteoporosis in postmenopausal women: the Japanese Osteoporosis Intervention Trial (JOINT) -04 and JOINT-05. Arch Osteoporosis, 17: 7, 2021. 6) Hong SJ, Yang BE, Yoo DM, Kim SJ, Choi HG, Byun SH: Analysis of the relationship between periodontitis and osteoporosis/fractures: a cross-sectional study. BMC Oral Health, 21: 125, 2021. 18) 藤盛真樹, 鳥谷部純行, 角 伸博, 嶋崎康相, 鈴木豊典, 阿部貴洋, 谷村晶広, 工藤章裕, 道念正樹, 川口 泰, 榊原典幸, 野島正寛, 牧野修治郎: 骨吸収抑制薬関連顎骨壊死の発生と治癒に関する前向き多施設共同研究 北海道東部十勝, 釧路・根室, オホーツク医療圏における顎骨壊死発生率. 日口腔外会誌, 67: 571-583, 2021. 15) 杉石 泰, 稲垣幸司, 黒須康成, 夫馬大介, 坂野雅洋, 山本弦太, 吉成伸夫, 野口俊英, 森田一三, 中垣晴男: 閉経後女性の歯周病所見と骨粗鬆症所見の関係. 日歯周病会誌, 48: 10-16, 2006. 19) Penoni DC, Fidalgo TKS, Torres SR, Varela VM, Masterson D, Leão ATT, Maia LC: Bone Density and clinical periodontal attachment in postmenopausal women: A systematic review and meta-analysis. J Dent Res, 96: 261-269, 2017. 12) Koide M, Kobayashi Y, Yamashita T, Uehara S, Nakamura M, Hiraoka BY, Ozaki Y, Iimura T, Yasuda H, Takahashi N, Udagawa N: Bone formation is coupled to resorption via suppression of sclerostin expression by osteoclasts. J Bone Miner Res, 32: 2074-2086, 2017. 4) Koide M, Kobayashi Y, Ninomiya T, Nakamura M, Yasuda H, Arai Y, Okahashi N, Yoshinari N, Takahashi N, Udagawa N: Osteoprotegerin-deficient male mice as a model for severe alveolar bone loss: comparison with RANKL-overexpressing transgenic male mice. Endocrinology, 154: 773-782, 2013. 16) Khan AA, et al: Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus. J Bone Miner Res, 30: 3-23, 2015. 11) Yoshida H, Hayashi S, Kunisada T, Ogawa M, Nishikawa S, Okamura H, Sudo T, Shultz LD: The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature, 345: 442-444, 1990. 21) Huang YF, Chang CT, Liu SP, Muo CH, Tsai CH, Hong HH, Shen YF, Wu CZ: The impact of oral hygiene maintenance on the association between periodontitis and osteoporosis: A nationwide population-based cross sectional study. Medicine, 95: e2348, 2016. 25) Katz J, Rotstein I: Prevalence of periapical lesions in patients with osteoporosis. J Endod, 47: 234-238, 2021. 3) Nakamura M, Udagawa N, Matsuura S, Mogi M, Nakamura H, Horiuchi H, Saito N, Hiraoka BY, Kobayashi Y, Takaoka K, Ozawa H, Miyazawa H, Takahashi N: Osteoprotegerin regulates bone formation through a coupling mechanism with bone resorption. Endocrinology, 144: 5441-5449, 2003. 17) Kunihara T, Tohmori H, Tsukamoto M, Kobayashi M, Okumura T, Teramoto H, Hamasaki T, Yamasaki T, Nakagawa T, Okimoto N, Fujiwara S: Incidence and trend of antiresorptive agent-related osteonecrosis of the jaw from 2016 to 2020 in Kure, Japan. Osteoporosis Int, 34: 1101-1109, 2023. |
| References_xml | – reference: 25) Katz J, Rotstein I: Prevalence of periapical lesions in patients with osteoporosis. J Endod, 47: 234-238, 2021. – reference: 7) Xu S, Zhang G, Guo JF, Tan YH: Associations between osteoporosis and risk of periodontitis: A pooled analysis of observational studies. Oral Dis, 27: 357-369, 2021. – reference: 23) Penoni DC, Torres SR, Farias MLF, Fernandes TM, Luiz RR, Leão ATT: Association of osteoporosis and bone medication with the periodontal condition in elderly women. Osteoporos Int, 27: 1887-1896, 2016. – reference: 2) Mizuno A, Amizuka N, Irie K, Murakami A, Fujise N, Kanno T, Sato Y, Nakagawa N, Yasuda H, Mochizuki S, Gomibuchi T, Yano K, Shima N, Washida N, Tsuda E, Morinaga T, Higashio K, Ozawa H: Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin. Biochem Biophys Res Commum, 247: 610-615, 1998. – reference: 8) Taguchi A, Uemura Y, Tanaka S, Ohta H, Mori S, Hagino H, Shiraki M, Nakamura T, Soen S, Adequate Treatment of Osteoporosis (A-TOP) research group: Influence of symptomatic periodontal disease on changes in skeletal bone density during medication therapy for osteoporosis in postmenopausal women: the Japanese Osteoporosis Intervention Trial (JOINT) -04 and JOINT-05. Arch Osteoporosis, 17: 7, 2021. – reference: 10) Takahashi N, Akatsu T, Udagawa N, Sasaki T, Yamaguchi A, Moseley JM, Martin TJ, Suda T: Osteoblastic cells are involved in osteoclast formation. Endocrinology, 123: 2600-2602, 1988. – reference: 22) Taguchi A, Shiraki M, Tanaka S, Ohshige H, Nakamura T: Improved periodontal disease and prevention of tooth loss in osteoporosis patients receiving once-yearly zoledronic acid: a randomized clinical trial. Menopause, 26: 1277-1283, 2019. – reference: 27) Mau LP, Kuan YC, Tsai YW, Lin JJ, Huynh-Ba G, Weng PW, Shieh YS, Cheng WC, Huang RY: Patients with chronic periodontitis present increased risk for osteoporosis: A population-based cohort study in Taiwan. J Periodontal Res, 52: 922-929, 2017. – reference: 6) Hong SJ, Yang BE, Yoo DM, Kim SJ, Choi HG, Byun SH: Analysis of the relationship between periodontitis and osteoporosis/fractures: a cross-sectional study. BMC Oral Health, 21: 125, 2021. – reference: 24) Taguchi A, Shiraki M, Sugimoto T, Ohta H, Soen S, Japan Osteoporosis Society: Lack of cooperation between physicians and dentists during osteoporosis treatment may increase fractures and osteonecrosis of the jaw. Curr Med Res Opin, 32: 1261-1268, 2016. – reference: 12) Koide M, Kobayashi Y, Yamashita T, Uehara S, Nakamura M, Hiraoka BY, Ozaki Y, Iimura T, Yasuda H, Takahashi N, Udagawa N: Bone formation is coupled to resorption via suppression of sclerostin expression by osteoclasts. J Bone Miner Res, 32: 2074-2086, 2017. – reference: 16) Khan AA, et al: Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus. J Bone Miner Res, 30: 3-23, 2015. – reference: 20) Ji S, Jin Tak Y, Han HD, Kim YJ, Lee SY, Lee JG, Jeong DW, Kim MJ: Low bone mineral density is associated with tooth loss in postmenopausal women: A nationwide representative study in Korea. J Womens Health (Larchmt), 25: 1159-1165, 2016. – reference: 17) Kunihara T, Tohmori H, Tsukamoto M, Kobayashi M, Okumura T, Teramoto H, Hamasaki T, Yamasaki T, Nakagawa T, Okimoto N, Fujiwara S: Incidence and trend of antiresorptive agent-related osteonecrosis of the jaw from 2016 to 2020 in Kure, Japan. Osteoporosis Int, 34: 1101-1109, 2023. – reference: 4) Koide M, Kobayashi Y, Ninomiya T, Nakamura M, Yasuda H, Arai Y, Okahashi N, Yoshinari N, Takahashi N, Udagawa N: Osteoprotegerin-deficient male mice as a model for severe alveolar bone loss: comparison with RANKL-overexpressing transgenic male mice. Endocrinology, 154: 773-782, 2013. – reference: 18) 藤盛真樹, 鳥谷部純行, 角 伸博, 嶋崎康相, 鈴木豊典, 阿部貴洋, 谷村晶広, 工藤章裕, 道念正樹, 川口 泰, 榊原典幸, 野島正寛, 牧野修治郎: 骨吸収抑制薬関連顎骨壊死の発生と治癒に関する前向き多施設共同研究 北海道東部十勝, 釧路・根室, オホーツク医療圏における顎骨壊死発生率. 日口腔外会誌, 67: 571-583, 2021. – reference: 15) 杉石 泰, 稲垣幸司, 黒須康成, 夫馬大介, 坂野雅洋, 山本弦太, 吉成伸夫, 野口俊英, 森田一三, 中垣晴男: 閉経後女性の歯周病所見と骨粗鬆症所見の関係. 日歯周病会誌, 48: 10-16, 2006. – reference: 3) Nakamura M, Udagawa N, Matsuura S, Mogi M, Nakamura H, Horiuchi H, Saito N, Hiraoka BY, Kobayashi Y, Takaoka K, Ozawa H, Miyazawa H, Takahashi N: Osteoprotegerin regulates bone formation through a coupling mechanism with bone resorption. Endocrinology, 144: 5441-5449, 2003. – reference: 1) Yasuda H, Shima N, Nakagawa N, Yamaguchi K, Kinosaki M, Mochizuki S, Tomoyasu A, Yano K, Goto M, Murakami A, Tsuda E, Morinaga T, Higashio K, Udagawa N, Takahashi N, Suda T: Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci USA, 95: 3597-3602, 1998. – reference: 14) Koide M, Yamashita T, Nakamura K, Yasuda H, Udagawa N, Kobayashi Y: Evidence for the major contribution of remodeling-based bone formation in sclerostin-deficient mice. Bone, 160: 116401, 2022. – reference: 9) Udagawa N, Takahashi N, Akatsu T, Tanaka H, Sasaki T, Nishihara T, Koga T, Martin TJ, Suda T: Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells. Proc Natl Acid Sci, 87: 7260-7264, 1990. – reference: 11) Yoshida H, Hayashi S, Kunisada T, Ogawa M, Nishikawa S, Okamura H, Sudo T, Shultz LD: The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature, 345: 442-444, 1990. – reference: 21) Huang YF, Chang CT, Liu SP, Muo CH, Tsai CH, Hong HH, Shen YF, Wu CZ: The impact of oral hygiene maintenance on the association between periodontitis and osteoporosis: A nationwide population-based cross sectional study. Medicine, 95: e2348, 2016. – reference: 26) Anbinder AL, Moraes RM, Lima GMG, Oliveira FE, Campos DRC, Rossoni RD, Oliveira LD, Junqueira JC, Ma Y, Elefteriou F: Periodontal disease exacerbates systemic ovariectomy-induced bone loss in mice. Bone, 83: 241-247, 2016. – reference: 5) Taguchi A, Urano T, Nakamura Y, Shiraki M: Increased Risk of Tooth Loss in Postmenopausal Women With Prevalent Vertebral Fractures.: An Observational Study. JBMR Plus, 7: e10822, 2023. – reference: 13) Koide M, Yamashita T, Murakami K, Uehara S, Nakamura K, Nakamura M, Matsushita M, Ara T, Yasuda H, Penninger JM, Takahashi N, Udagawa N, Kobayashi Y: Sclerostin expression in trabecular bone is downregulated by osteoclasts. Sci Rep, 10: 13751, 2020. – reference: 19) Penoni DC, Fidalgo TKS, Torres SR, Varela VM, Masterson D, Leão ATT, Maia LC: Bone Density and clinical periodontal attachment in postmenopausal women: A systematic review and meta-analysis. J Dent Res, 96: 261-269, 2017. |
| SSID | ssib000872039 ssib023160750 ssib002822002 ssib005901892 ssj0041828 ssib002484695 ssib005880044 ssib004298385 |
| Score | 2.3789678 |
| Snippet | 「はじめに」骨組織は, 骨吸収と骨形成のバランスにより調節されている. それらのバランス調節は, 互いにあたかも連絡を取り合っているかのようにみえるため, この現象は, ... |
| SourceID | medicalonline jstage |
| SourceType | Publisher |
| StartPage | 9 |
| SubjectTerms | 歯周病 破骨細胞 骨代謝カップリング 骨粗鬆症 骨芽細胞 |
| Title | 歯周病と骨粗鬆症のクロストーク |
| URI | https://www.jstage.jst.go.jp/article/perio/66/1/66_9/_article/-char/ja http://mol.medicalonline.jp/en/journal/download?GoodsID=cp9perlo/2024/006601/002&name=0009-0016j |
| Volume | 66 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | 日本歯周病学会会誌, 2024/03/31, Vol.66(1), pp.9-16 |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1880-408X dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0041828 issn: 0385-0110 databaseCode: KQ8 dateStart: 19680101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpR3LbtQw0CrlABJCPEV5qQd8QilJ7HjtG_E2VQUCCamVeos2r8OqtBVsL9zaiseVU3-hQpRK3JD4mwhW_QtmJsmuixAq5ZJ1xpPxzDjJzGTHY8YeVLIIVFkIL8-k9GQVRt6g6mWeKPIqK4rM-LRI7Nlztbwqn6xFazPnaidraXuULeRv_riu5CyzCjCYV1wl-w8zOyEKAGjD_MIRZhiOp5pjnigeL_J4iScRNwGPNU963PS4jngiwEkkiOFx3HbZEHsR0udadci9DjmhRkgEoSGQeAOxpoVo3TZsf4LsOrjIEtCMI2r0caC_MRlRF3AikaCJnYZGtvXkIy7iWp9rIgMs2xjvDpTF2JaUNnxqVmkQiZdgzxKPRYMPXGmukyka4GgSFHoWkUFCgwESQOs0Y1phdezyAwpD5TkD2R4SIQoAglEDagBj1v2-EspuwWH7RCARYB_VTGRRAYb4SUhtiltFgmjiBU6BqiWI5YaUbQU1JGrGxg__cyIcAyE0Jl62acFlY8DgfexJn7Zrnli4Zl-bE09yY66M4_c0S15_t6jgcGNBWqy6vbmg1IKZ-g2TbM72_k8JKVUqDfBg0g6O6wfTIQQx50Mwvbi_ytMXbgyAmQCujw4usVtzD1xY361RFxotnIJLEUjsOz4qLqbW01QBiF8UusWdeyYhoCb3rFNeU7MY5Xw0lRL80SFEZ1h249LL5h_TpnKN43yuXGGX26hxPm5EvcpmhoNr7MIiZvrhZo3Xmffz8OjHx4Px_tt65-D408H46_7x53fj_ff1zpd696jeO6x3v9V7H-q973B6g60uJSv9Za_dCcUbok328kqobDDI87zsYW3xrNJgpwelkhWIHpRYeDHMI4V7EPtl4Be6wpSGIFSgLFlk4iab3djcKG-xea1MIKIsBB3n0jcFXJCVkQ78sqwGQSbmmGokT7eacjfpKad3jj0-oam0fVG-TvMtA9eub6b4eKUY5PgB_ISY-GJSKvInlFQivH3Wse-wi9NH9y6bHb3aLu9BsDDK7tPN9gsNfdZ2 |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E6%AD%AF%E5%91%A8%E7%97%85%E3%81%A8%E9%AA%A8%E7%B2%97%E9%AC%86%E7%97%87%E3%81%AE%E3%82%AF%E3%83%AD%E3%82%B9%E3%83%88%E3%83%BC%E3%82%AF&rft.jtitle=%E6%97%A5%E6%9C%AC%E6%AD%AF%E5%91%A8%E7%97%85%E5%AD%A6%E4%BC%9A%E4%BC%9A%E8%AA%8C&rft.au=%E5%B0%8F%E5%87%BA%2C+%E9%9B%85%E5%89%87&rft.au=%E7%94%B0%E5%8F%A3%2C+%E6%98%8E&rft.au=%E4%B8%AD%E6%9D%91%2C+%E7%BE%8E%E3%81%A9%E3%82%8A&rft.au=%E5%AE%87%E7%94%B0%E5%B7%9D%2C+%E4%BF%A1%E4%B9%8B&rft.date=2024-03-31&rft.pub=%E7%89%B9%E5%AE%9A%E9%9D%9E%E5%96%B6%E5%88%A9%E6%B4%BB%E5%8B%95%E6%B3%95%E4%BA%BA+%E6%97%A5%E6%9C%AC%E6%AD%AF%E5%91%A8%E7%97%85%E5%AD%A6%E4%BC%9A&rft.issn=0385-0110&rft.eissn=1880-408X&rft.volume=66&rft.issue=1&rft.spage=9&rft.epage=16&rft_id=info:doi/10.2329%2Fperio.66.9&rft.externalDocID=article_perio_66_1_66_9_article_char_ja |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0385-0110&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0385-0110&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0385-0110&client=summon |