大腸がんの予防に向けた生活習慣 〜運動と肥満からみたメカニズム論を加えて

• Published in: Tairyoku kagaku. Japanese journal of physical fitness and sports medicine Vol. 67; no. 2; pp. 141 - 146
• Main Authors: 武藤, 倫弘, 田村, 秀哉, 鱧屋, 隆博, 藤井, 元
• Format: Journal Article
• Language: Japanese
• Published: Tokyo 一般社団法人日本体力医学会 01.01.2018; Japan Science and Technology Agency
• Subjects: Colorectal cancer; Exercise; Obesity; Physical fitness; Tumorigenesis
• ISSN: 0039-906X; 1881-4751
• DOI: 10.7600/jspfsm.67.141

Obesity-associated cancers, including colorectal cancer, are increasing in Japan with Westernized lifestyles as exemplified by reduced physical activity and increased high-fat diet. An excessive accumulation of visceral adipose tissue causes insulin resistance, oxidative stress and adipocytokine imbalance, and these factors are suggested to be involved in colorectal tumorigenesis. In this review article, we focus on the relationships between each of the individual associated conditions, especially obesity and exercise, and colorectal tumor development with targeting molecules revealed by in vivo and in vitro studies. Furthermore, the potential for colorectal cancer prevention by targeting these molecules is discussed.