多系統萎縮症における眼球運動障害―50例における経時的検討
多系統萎縮症における眼球運動障害の特徴を明らかにするため，50例を対象に9種類の眼運動系パラメーターの経時的変化を検討した．各パラメーターにおける異常出現率は，いずれも病型間（小脳失調先行型とパーキンソニズム先行型）で有意差をみとめなかった．また，経時的変化からパラメーターは3群―病初期から異常出現率が高頻度にみとめられる群，経過とともに徐々に高率化する群，進行しても比較的低値にとどまる群―に大別された．各群のそれぞれの代表として，頭位変換性眼振，視性抑制反応および温度眼振に注目し，これらの機能解剖学的検討から，病変は小脳の背側虫部次いで片葉，そして前庭神経核から前庭皮質にもおよぶと考えた．...
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| Published in | 臨床神経学 Vol. 52; no. 4; pp. 218 - 226 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
日本神経学会
2012
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0009-918X 1882-0654 |
| DOI | 10.5692/clinicalneurol.52.218 |
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| Abstract | 多系統萎縮症における眼球運動障害の特徴を明らかにするため，50例を対象に9種類の眼運動系パラメーターの経時的変化を検討した．各パラメーターにおける異常出現率は，いずれも病型間（小脳失調先行型とパーキンソニズム先行型）で有意差をみとめなかった．また，経時的変化からパラメーターは3群―病初期から異常出現率が高頻度にみとめられる群，経過とともに徐々に高率化する群，進行しても比較的低値にとどまる群―に大別された．各群のそれぞれの代表として，頭位変換性眼振，視性抑制反応および温度眼振に注目し，これらの機能解剖学的検討から，病変は小脳の背側虫部次いで片葉，そして前庭神経核から前庭皮質にもおよぶと考えた． |
|---|---|
| AbstractList | 多系統萎縮症における眼球運動障害の特徴を明らかにするため，50例を対象に9種類の眼運動系パラメーターの経時的変化を検討した．各パラメーターにおける異常出現率は，いずれも病型間（小脳失調先行型とパーキンソニズム先行型）で有意差をみとめなかった．また，経時的変化からパラメーターは3群―病初期から異常出現率が高頻度にみとめられる群，経過とともに徐々に高率化する群，進行しても比較的低値にとどまる群―に大別された．各群のそれぞれの代表として，頭位変換性眼振，視性抑制反応および温度眼振に注目し，これらの機能解剖学的検討から，病変は小脳の背側虫部次いで片葉，そして前庭神経核から前庭皮質にもおよぶと考えた． |
| Author | 飛澤, 晋介 松原, 四郎 磯崎, 英治 内藤, 理恵 水谷, 俊雄 |
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| References | 21) Tsuchiya K, Watabiki S, Sano M, et al. Distribution of cerebellar lesions in multiple system atrophy: a topographic neuropathological study of three autopsy cases in Japan. J Neurol Sci 1998;155:80-85. 15) 水野正浩, 山根雅昭, 小山内龍一. 脊髄小脳変性症におけるvisual suppression testについて. 耳鼻臨床 1988;81:165-171. 1) Klostermann V, Zühlke C, Heide W, et al. Slow saccades and other movement disorders in spinocerebellar atrophy type 1. J Neurol 1997;244:105-111. 28) Ventre J, Faugier-Grimaud S. Effects of posterior parietal lesions (area 7) on VOR in monkeys. Exp Brain Res 1986;62:654-658. 25) Kato I, Kawasaki T, Aoyagi M, et al. Loss of visual suppression of caloric nystagmus in cats. Acta Otolaryngol 1979;87:499-505. 9) 水野正浩. 脊髄小脳変性症における神経耳科学的所見. 耳鼻臨床 1981;74:63-88. 22) Wakabayashi K, Mori F, Nishie M, et al. An autopsy case of early ("minimal change") olivopontocerebellar atrophy (multiple system atrophy-cerebellar). Acta Neuropathol 2005;110:185-190. 10) Gilman S, Low PA, Quinn N, et al. Consensus statement on the diagnosis of multiple system atrophy. J Auton Nerv Sys 1998;74:189-192. 16) 古川朋靖, 渡辺道隆, 正木義男ら. オリーブ橋小脳萎縮症の神経耳科学的検討. 耳鼻臨床 1999;92:347-354. 6) Anderson T, Luxon L, Quinn N, et al. Oculomotor function in multiple system atrophy: Clinical and laboratory features in 30 patients. Mov Disord 2008;23:977-984. 13) Yoshizawa T, Nakamagoe K, Ueno T, et al. Early vestibular dysfunction in Machado-Joseph disease detected by caloric test. J Neurol Sci 2004;221:109-111. 27) Grüsser OJ, Pause M, Schreiter U. Localisation and responses of neurons in the parieto-insular vestibular cortex of awake monkeys (macaca fascicularis). J Physiol 1990;430:537-557. 24) Eadie MJ. Olivo-ponto-cerebellar atrophy (Dejerine-Thomas type). In: Vinken PJ, Bruyn GW, Klawans HL, editors. Handbook of clinical neurology. Vol 21. Amsterdam: Elsevier; 1975. p. 415-431. 2) Seifried C, Velázquez-Pérez L, Santos-Falcón N, et al. Saccade velocity as a surrogate disease marker in spinocerebellar ataxia type 2. Ann NY Acad Sci 2005;1039:524-527. 14) Meco G, Gasparini M, Doricchi F. Attentional functions in multiple system atrophy and Parkinson's disease. J Neurol Neurosurg Psychiatry 1996;60:393-398. 23) 藤盛寿一, 館脇康子, 清水 洋ら. 拡散テンソル画像法をもちいた多系統萎縮症における橋小脳路変性の検討. 臨床神経 2011;51:271-274. 26) Bottini G, Sterzi R, Paulesu E, et al. Identification of the central vestibular projections in man: a positron emission tomography activation study. Exp Brain Res 1994;99:164-169. 3) Velázquez-Pérez L, Seifried C, Abele M, et al. Saccade velocity is reduced in presymptomatic spinocerebellar ataxia type 2. Clin Neurophysiol 2009;120:632-635. 18) Leigh RJ, Zee DS. Diagnosis of central disorders of ocular motility. In: Leigh RJ, Zee DS, editors. Neurology of the eye movements. Fourth Edition. Oxford univ press; 2006. p. 598-718. 19) Wenning GK, Tison F, Elliott L, et al. Olivopontocerebellar pathology in multiple system atrophy. Mov Disord 1996;11:157-162. 5) Rascol O, Sabatini U, Fabre N, et al. Abnormal vestibuloocular reflex cancellation in multiple system atrophy and progressive supranuclear palsy but not in Parkinson's disease. Mov Disord 1995;10:163-170. 12) Yabe I, Sasaki H, Takeichi N, et al. Positional vertigo and macroscopic downbeat positioning nystagmus in spinocerebellar ataxia type 6 (SCA6). J Nerurol 2003;250:440-443. 29) Horimoto Y, Aiba I, Yasuda T, et al. Cerebral atrophy in multiple system atrophy by MRI. J Neurol Sci 2000;173:109-112. 8) Takemori S. Visual suppression test. Adv Oto-Rhinol-Laryngol 1983;29:102-110. 11) Bertholon P, Bronstein AM, Davies RA, et al. Positional down beating nystagmus in 50 patients: cerebellar disorders and possible anterior semicircular canalithiasis. J Neurol Neurosurg Psychiatry 2002;72:366-372. 4) Gordon CR, Joffe V, Vainstein G, et al. Vestibulo-ocular arreflexia in families with spinocerebellar ataxia type 3 (Machado-Joseph disease). J Neurol Neurosurg Psychiatry 2003;74:1403-1406. 7) Lee J-Y, Lee W-W, Kim JS, et al. Perverted head-shaking and positional downbeat nystagmus in patients with multiple system atrophy. Mov Disord 2009;24:1290-1295. 17) 縄田安孝, 古川朋靖, 渡辺道隆ら. 神経変性疾患における垂直眼球運動障害について. 日耳鼻 1997;100:770-781. 20) 水谷俊雄. 歯状核系変性症における眼球運動障害の神経病理学的背景―とくにSlow Saccadeについて―. 神経進歩 1990;34:68-77. |
| References_xml | – reference: 2) Seifried C, Velázquez-Pérez L, Santos-Falcón N, et al. Saccade velocity as a surrogate disease marker in spinocerebellar ataxia type 2. Ann NY Acad Sci 2005;1039:524-527. – reference: 6) Anderson T, Luxon L, Quinn N, et al. Oculomotor function in multiple system atrophy: Clinical and laboratory features in 30 patients. Mov Disord 2008;23:977-984. – reference: 21) Tsuchiya K, Watabiki S, Sano M, et al. Distribution of cerebellar lesions in multiple system atrophy: a topographic neuropathological study of three autopsy cases in Japan. J Neurol Sci 1998;155:80-85. – reference: 3) Velázquez-Pérez L, Seifried C, Abele M, et al. Saccade velocity is reduced in presymptomatic spinocerebellar ataxia type 2. Clin Neurophysiol 2009;120:632-635. – reference: 16) 古川朋靖, 渡辺道隆, 正木義男ら. オリーブ橋小脳萎縮症の神経耳科学的検討. 耳鼻臨床 1999;92:347-354. – reference: 19) Wenning GK, Tison F, Elliott L, et al. Olivopontocerebellar pathology in multiple system atrophy. Mov Disord 1996;11:157-162. – reference: 7) Lee J-Y, Lee W-W, Kim JS, et al. Perverted head-shaking and positional downbeat nystagmus in patients with multiple system atrophy. Mov Disord 2009;24:1290-1295. – reference: 26) Bottini G, Sterzi R, Paulesu E, et al. Identification of the central vestibular projections in man: a positron emission tomography activation study. Exp Brain Res 1994;99:164-169. – reference: 20) 水谷俊雄. 歯状核系変性症における眼球運動障害の神経病理学的背景―とくにSlow Saccadeについて―. 神経進歩 1990;34:68-77. – reference: 17) 縄田安孝, 古川朋靖, 渡辺道隆ら. 神経変性疾患における垂直眼球運動障害について. 日耳鼻 1997;100:770-781. – reference: 14) Meco G, Gasparini M, Doricchi F. Attentional functions in multiple system atrophy and Parkinson's disease. J Neurol Neurosurg Psychiatry 1996;60:393-398. – reference: 4) Gordon CR, Joffe V, Vainstein G, et al. Vestibulo-ocular arreflexia in families with spinocerebellar ataxia type 3 (Machado-Joseph disease). J Neurol Neurosurg Psychiatry 2003;74:1403-1406. – reference: 25) Kato I, Kawasaki T, Aoyagi M, et al. Loss of visual suppression of caloric nystagmus in cats. Acta Otolaryngol 1979;87:499-505. – reference: 22) Wakabayashi K, Mori F, Nishie M, et al. An autopsy case of early ("minimal change") olivopontocerebellar atrophy (multiple system atrophy-cerebellar). Acta Neuropathol 2005;110:185-190. – reference: 24) Eadie MJ. Olivo-ponto-cerebellar atrophy (Dejerine-Thomas type). In: Vinken PJ, Bruyn GW, Klawans HL, editors. Handbook of clinical neurology. Vol 21. Amsterdam: Elsevier; 1975. p. 415-431. – reference: 13) Yoshizawa T, Nakamagoe K, Ueno T, et al. Early vestibular dysfunction in Machado-Joseph disease detected by caloric test. J Neurol Sci 2004;221:109-111. – reference: 15) 水野正浩, 山根雅昭, 小山内龍一. 脊髄小脳変性症におけるvisual suppression testについて. 耳鼻臨床 1988;81:165-171. – reference: 18) Leigh RJ, Zee DS. Diagnosis of central disorders of ocular motility. In: Leigh RJ, Zee DS, editors. Neurology of the eye movements. Fourth Edition. Oxford univ press; 2006. p. 598-718. – reference: 8) Takemori S. Visual suppression test. Adv Oto-Rhinol-Laryngol 1983;29:102-110. – reference: 10) Gilman S, Low PA, Quinn N, et al. Consensus statement on the diagnosis of multiple system atrophy. J Auton Nerv Sys 1998;74:189-192. – reference: 12) Yabe I, Sasaki H, Takeichi N, et al. Positional vertigo and macroscopic downbeat positioning nystagmus in spinocerebellar ataxia type 6 (SCA6). J Nerurol 2003;250:440-443. – reference: 27) Grüsser OJ, Pause M, Schreiter U. Localisation and responses of neurons in the parieto-insular vestibular cortex of awake monkeys (macaca fascicularis). J Physiol 1990;430:537-557. – reference: 28) Ventre J, Faugier-Grimaud S. Effects of posterior parietal lesions (area 7) on VOR in monkeys. Exp Brain Res 1986;62:654-658. – reference: 23) 藤盛寿一, 館脇康子, 清水 洋ら. 拡散テンソル画像法をもちいた多系統萎縮症における橋小脳路変性の検討. 臨床神経 2011;51:271-274. – reference: 9) 水野正浩. 脊髄小脳変性症における神経耳科学的所見. 耳鼻臨床 1981;74:63-88. – reference: 11) Bertholon P, Bronstein AM, Davies RA, et al. Positional down beating nystagmus in 50 patients: cerebellar disorders and possible anterior semicircular canalithiasis. J Neurol Neurosurg Psychiatry 2002;72:366-372. – reference: 1) Klostermann V, Zühlke C, Heide W, et al. Slow saccades and other movement disorders in spinocerebellar atrophy type 1. J Neurol 1997;244:105-111. – reference: 29) Horimoto Y, Aiba I, Yasuda T, et al. Cerebral atrophy in multiple system atrophy by MRI. J Neurol Sci 2000;173:109-112. – reference: 5) Rascol O, Sabatini U, Fabre N, et al. Abnormal vestibuloocular reflex cancellation in multiple system atrophy and progressive supranuclear palsy but not in Parkinson's disease. Mov Disord 1995;10:163-170. |
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| SubjectTerms | 下眼瞼向き眼振 前庭皮質 多系統萎縮症 温度眼振 眼球運動障害 |
| Title | 多系統萎縮症における眼球運動障害―50例における経時的検討 |
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