A new boronic acid-based fluorescent sensor for L-dihydroxy-phenylalanine

Catecholamines, such as dopamine and L-dihydroxyphenylalanine (L-DOPA), are associated with different physiological functions and diseases. In our recent studies, a novel water-soluble boronic acid compound 3c was identified as a selective fluorescent sensor for L-DOPA. This compound not only has th...

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Bibliographic Details
Published inDrug Discoveries & Therapeutics Vol. 6; no. 5; pp. 238 - 241
Main Authors Wu, Zhongyu, Wang, Binghe, Xu, Wenfang, Yang, Xinying, Fang, Hao
Format Journal Article
LanguageEnglish
Published International Research and Cooperation Association for Bio & Socio-Sciences Advancement 01.01.2012
Subjects
Boronic acid
dopamine
fluorescent chemosensor
L-DOPA
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ISSN1881-7831
1881-784X
DOI10.5582/ddt.2012.v6.5.238

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Summary:Catecholamines, such as dopamine and L-dihydroxyphenylalanine (L-DOPA), are associated with different physiological functions and diseases. In our recent studies, a novel water-soluble boronic acid compound 3c was identified as a selective fluorescent sensor for L-DOPA. This compound not only has the ability to interact with dopamine and catechol, but also has no fluorescence intensity change for L-DOPA precursors in vivo, such as L-tyrosine.
ISSN:1881-7831
1881-784X
DOI:10.5582/ddt.2012.v6.5.238